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Catherine M. Stein, PhD

Associate Professor

catherine.stein@case.edu | 216.368.5631 | Wolstein Research Building, 1316

Education

Ph.D. Epidemiology and Biostatistics, Case Western Reserve University. Cleveland, OH. 2004. Dissertation:  Genetic and environmental influences on tuberculosis susceptibility.

Professional Summary

Dr. Stein’s research focuses on complex genetic disorders. Her primary research focus is in the study of genetic and environmental susceptibility to tuberculosis. She is the Genetics Working Group Leader of the Tuberculosis Research Unit and co-PI of the Kawempe Community Health Study, a large household contact study of TB. She also conducts collaborative research in HIV, Rift Valley Fever Virus, and speech-sound disorder. In addition, she is interested in applying multivariate methods, particularly structural equation models, to the joint analysis of related traits, genes, and clinical covariates.

Ongoing Research Projects

Tuberculosis: Examining the influence of epidemiological risk factors, host genetics, microbial genetics, and host immunology on thd development of latent M. tuberculosis infection and active TB disease

Speech-sound disorder: Modeling the relationships of cognitive domains underlying speech-sound disorder, how these predict later outcomes in reading deficiency, and mapping genes underlying both these clinical traits and endophenotypes

Structural Equation Modeling in Family Data: We have released ‘strum’ software, an R package that implements a generalized framework to conduct SEM analyses in family data based on methodology developed by Dr. Nathan Morris

Recent Publications

  1. Stein, CM, Mayanja-Kizza, H, Hawn, TR, Boom, WH. Importance of study design and phenotype definition in ongoing studies of resistance to latent M. tuberculosis infection. J. Infect. Dis. 2019; : . PubMed PMID:31665355 .
  2. Lewis, BA, Freebairn, L, Tag, J, Igo, RP Jr, Ciesla, A, Iyengar, SK, Stein, CM, Taylor, HG. Differential Long-Term Outcomes for Individuals With Histories of Preschool Speech Sound Disorders. Am J Speech Lang Pathol 2019; : 1-15. PubMed PMID:31604025 .
  3. Wampande, EM, Naniima, P, Mupere, E, Kateete, DP, Malone, LL, Stein, CM, Mayanja-Kizza, H, Gagneux, S, Boom, WH, Joloba, ML. Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda. PLoS ONE 2019; 14 (9): e0221644. PubMed PMID:31498808 PubMed Central PMC6733460.
  4. Miller, GJ, Lewis, B, Benchek, P, Freebairn, L, Tag, J, Budge, K, Iyengar, SK, Voss-Hoynes, H, Taylor, HG, Stein, C. Reading Outcomes for Individuals With Histories of Suspected Childhood Apraxia of Speech. Am J Speech Lang Pathol 2019; : 1-16. PubMed PMID:31419159 .
  5. Lu, LL, Smith, MT, Yu, KKQ, Luedemann, C, Suscovich, TJ, Grace, PS, Cain, A, Yu, WH, McKitrick, TR, Lauffenburger, D, Cummings, RD, Mayanja-Kizza, H, Hawn, TR, Boom, WH, Stein, CM, Fortune, SM, Seshadri, C, Alter, G. Publisher Correction: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nat. Med. 2019; 25 (7): 1175. PubMed PMID:31222179 .
  6. Lu, LL, Smith, MT, Yu, KKQ, Luedemann, C, Suscovich, TJ, Grace, PS, Cain, A, Yu, WH, McKitrick, TR, Lauffenburger, D, Cummings, RD, Mayanja-Kizza, H, Hawn, TR, Boom, WH, Stein, CM, Fortune, SM, Seshadri, C, Alter, G. IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nat. Med. 2019; 25 (6): 977-987. PubMed PMID:31110348 PubMed Central PMC6559862.
  7. Stein, CM, Ponsaran, R, Trapl, ES, Goldenberg, AJ. Correction: Experiences and perspectives on the return of secondary findings among genetic epidemiologists. Genet. Med. 2019; 21 (6): 1463. PubMed PMID:30792497 .
  8. Lewis, BA, Freebairn, L, Tag, J, Benchek, P, Morris, NJ, Iyengar, SK, Taylor, HG, Stein, CM. Heritability and longitudinal outcomes of spelling skills in individuals with histories of early speech and language disorders. Learn Individ Differ 2018; 65 : 1-11. PubMed PMID:30555216 PubMed Central PMC6294329.
  9. Stein, CM, Ponsaran, R, Trapl, ES, Goldenberg, AJ. Experiences and perspectives on the return of secondary findings among genetic epidemiologists. Genet. Med. 2019; 21 (7): 1541-1547. PubMed PMID:30467403 .
  10. Stein, CM, Nsereko, M, Malone, LL, Okware, B, Kisingo, H, Nalukwago, S, Chervenak, K, Mayanja-Kizza, H, Hawn, TR, Boom, WH. Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda. Clin. Infect. Dis. 2019; 68 (10): 1705-1712. PubMed PMID:30165605 PubMed Central PMC6495009.
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