Catherine M. Stein, PhD

Associate Professor | 216.368.5631 | Wolstein Research Building, 1316


Ph.D. Epidemiology and Biostatistics, Case Western Reserve University. Cleveland, OH. 2004. Dissertation:  Genetic and environmental influences on tuberculosis susceptibility.

Professional Summary

Dr. Stein’s research focuses on complex genetic disorders. Her primary research focus is in the study of genetic and environmental susceptibility to tuberculosis. She is the Genetics Working Group Leader of the Tuberculosis Research Unit and co-PI of the Kawempe Community Health Study, a large household contact study of TB. She also conducts collaborative research in HIV, Rift Valley Fever Virus, and speech-sound disorder. In addition, she is interested in applying multivariate methods, particularly structural equation models, to the joint analysis of related traits, genes, and clinical covariates.

Ongoing Research Projects

Tuberculosis: Examining the influence of epidemiological risk factors, host genetics, microbial genetics, and host immunology on thd development of latent M. tuberculosis infection and active TB disease

Speech-sound disorder: Modeling the relationships of cognitive domains underlying speech-sound disorder, how these predict later outcomes in reading deficiency, and mapping genes underlying both these clinical traits and endophenotypes

Structural Equation Modeling in Family Data: We have released ‘strum’ software, an R package that implements a generalized framework to conduct SEM analyses in family data based on methodology developed by Dr. Nathan Morris

Recent Publications

  1. Stein, CM, Ponsaran, R, Trapl, ES, Goldenberg, AJ. Correction: Experiences and perspectives on the return of secondary findings among genetic epidemiologists. Genet. Med. 2019; : . PubMed PMID:30792497 .
  2. Lewis, BA, Freebairn, L, Tag, J, Benchek, P, Morris, NJ, Iyengar, SK, Taylor, HG, Stein, CM. Heritability and longitudinal outcomes of spelling skills in individuals with histories of early speech and language disorders. Learn Individ Differ 2018; 65 : 1-11. PubMed PMID:30555216 PubMed Central PMC6294329.
  3. Stein, CM, Ponsaran, R, Trapl, ES, Goldenberg, AJ. Experiences and perspectives on the return of secondary findings among genetic epidemiologists. Genet. Med. 2018; : . PubMed PMID:30467403 .
  4. Stein, CM, Nsereko, M, Malone, LL, Okware, B, Kisingo, H, Nalukwago, S, Chervenak, K, Mayanja-Kizza, H, Hawn, TR, Boom, WH. Long-term stability of resistance to latent M. tuberculosis infection in highly exposed TB household contacts in Kampala, Uganda. Clin. Infect. Dis. 2018; : . PubMed PMID:30165605 .
  5. Igo, RP Jr, Hall, NB, Malone, LL, Hall, JB, Truitt, B, Qiu, F, Tao, L, Mupere, E, Schnell, A, Hawn, TR, Bush, WS, Joloba, M, Boom, WH, Stein, CM. Fine-mapping analysis of a chromosome 2 region linked to resistance to Mycobacterium tuberculosis infection in Uganda reveals potential regulatory variants. Genes Immun. 2018; : . PubMed PMID:30100616 PubMed Central PMC6374218.
  6. Fluegge, K, Malone, LL, Nsereko, M, Okware, B, Wejse, C, Kisingo, H, Mupere, E, Boom, WH, Stein, CM. Impact of geographic distance on appraisal delay for active TB treatment seeking in Uganda: a network analysis of the Kawempe Community Health Cohort Study. BMC Public Health 2018; 18 (1): 798. PubMed PMID:29940918 PubMed Central PMC6019214.
  7. Simmons, JD, Stein, CM, Seshadri, C, Campo, M, Alter, G, Fortune, S, Schurr, E, Wallis, RS, Churchyard, G, Mayanja-Kizza, H, Boom, WH, Hawn, TR. Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat. Rev. Immunol. 2018; 18 (9): 575-589. PubMed PMID:29895826 PubMed Central PMC6278832.
  8. Mekonnen, E, Bekele, E, Stein, CM. Novel polymorphisms in TICAM2 and NOD1 associated with tuberculosis progression phenotypes in Ethiopian populations. Glob Health Epidemiol Genom 2018; 3 : e1. PubMed PMID:29868226 PubMed Central PMC5870410.
  9. Papp, AC, Azad, AK, Pietrzak, M, Williams, A, Handelman, SK, Igo, RP Jr, Stein, CM, Hartmann, K, Schlesinger, LS, Sadee, W. AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection. PLoS ONE 2018; 13 (5): e0198221. PubMed PMID:29847580 PubMed Central PMC5976201.
  10. Stein, CM, Sausville, L, Wejse, C, Sobota, RS, Zetola, NM, Hill, PC, Boom, WH, Scott, WK, Sirugo, G, Williams, SM. Genomics of human pulmonary tuberculosis: from genes to pathways. Curr Genet Med Rep 2017; 5 (4): 149-166. PubMed PMID:29805915 PubMed Central PMC5965286.
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