Rob Igo_crop

Rob Igo, PhD

Assistant Professor

rpi@.case.edu | 216.368.4562 | Wolstein Research Bldg. Rm. 1302

Education

B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005

Research Interests

I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, age-related macular degeneration and susceptibility to tuberculosis.

Professional Memberships

American Society of Human Genetics
International Genetic Epidemiology Society

Courses Taught

EPBI 452: Statistical Methods for Genetic Epidemiology
EPBI 502: Genetic Epidemiology Seminar

Recent Publications

  1. Afshari, NA, Igo, RP Jr, Morris, NJ, Stambolian, D, Sharma, S, Pulagam, VL, Dunn, S, Stamler, JF, Truitt, BJ, Rimmler, J, Kuot, A, Croasdale, CR, Qin, X, Burdon, KP, Riazuddin, SA, Mills, R, Klebe, S, Minear, MA, Zhao, J, Balajonda, E, Rosenwasser, GO, Baratz, KH, Mootha, VV, Patel, SV, Gregory, SG, Bailey-Wilson, JE, Price, MO, Price, FW Jr, Craig, JE, Fingert, JH, Gottsch, JD, Aldave, AJ, Klintworth, GK, Lass, JH, Li, YJ, Iyengar, SK. Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun 2017; 8 : 14898. PubMed PMID:28358029 PubMed Central PMC5379100.
  2. Pasquale, LR, Aschard, H, Kang, JH, Bailey, JN, Lindström, S, Chasman, DI, Christen, WG, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, J, Budenz, DL, Realini, T, Gaasterland, T, Gaasterland, D, Scott, WK, Singh, K, Sit, AJ, Igo, RP Jr, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Havens, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Haines, JL, Wiggs, JL. Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample. Menopause 2017; 24 (2): 150-156. PubMed PMID:27760082 PubMed Central PMC5266624.
  3. Cooke Bailey, JN, Igo, RP Jr. Genetic Risk Scores. Curr Protoc Hum Genet 2016; 91 : 1.29.1-1.29.9. PubMed PMID:27727440 .
  4. Liu, Y, Bailey, JC, Helwa, I, Dismuke, WM, Cai, J, Drewry, M, Brilliant, MH, Budenz, DL, Christen, WG, Chasman, DI, Fingert, JH, Gaasterland, D, Gaasterland, T, Gordon, MO, Igo, RP Jr, Kang, JH, Kass, MA, Kraft, P, Lee, RK, Lichter, P, Moroi, SE, Realini, A, Richards, JE, Ritch, R, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Song, YE, Vollrath, D, Weinreb, R, Medeiros, F, Wollstein, G, Zack, DJ, Zhang, K, Pericak-Vance, MA, Gonzalez, P, Stamer, WD, Kuchtey, J, Kuchtey, RW, Allingham, RR, Hauser, MA, Pasquale, LR, Haines, JL, Wiggs, JL. A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. Invest. Ophthalmol. Vis. Sci. 2016; 57 (10): 3974-81. PubMed PMID:27537254 .
  5. Igo, RP Jr, Cooke Bailey, JN, Romm, J, Haines, JL, Wiggs, JL. Quality Control for the Illumina HumanExome BeadChip. Curr Protoc Hum Genet 2016; 90 : 2.14.1-2.14.16. PubMed PMID:27367164 PubMed Central PMC5100670.
  6. Williams, RC, Elston, RC, Kumar, P, Knowler, WC, Abboud, HE, Adler, S, Bowden, DW, Divers, J, Freedman, BI, Igo, RP Jr, Ipp, E, Iyengar, SK, Kimmel, PL, Klag, MJ, Kohn, O, Langefeld, CD, Leehey, DJ, Nelson, RG, Nicholas, SB, Pahl, MV, Parekh, RS, Rotter, JI, Schelling, JR, Sedor, JR, Shah, VO, Smith, MW, Taylor, KD, Thameem, F, Thornley-Brown, D, Winkler, CA, Guo, X, Zager, P, Hanson, RL, FIND Research Group. Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics 2016; 17 : 325. PubMed PMID:27142425 PubMed Central PMC4855449.
  7. Fan, Q, Verhoeven, VJ, Wojciechowski, R, Barathi, VA, Hysi, PG, Guggenheim, JA, Höhn, R, Vitart, V, Khawaja, AP, Yamashiro, K, Hosseini, SM, Lehtimäki, T, Lu, Y, Haller, T, Xie, J, Delcourt, C, Pirastu, M, Wedenoja, J, Gharahkhani, P, Venturini, C, Miyake, M, Hewitt, AW, Guo, X, Mazur, J, Huffman, JE, Williams, KM, Polasek, O, Campbell, H, Rudan, I, Vatavuk, Z, Wilson, JF, Joshi, PK, McMahon, G, St Pourcain, B, Evans, DM, Simpson, CL, Schwantes-An, TH, Igo, RP, Mirshahi, A, Cougnard-Gregoire, A, Bellenguez, C, Blettner, M, Raitakari, O, Kähönen, M, Seppala, I, Zeller, T, Meitinger, T, Consortium for Refractive Error and Myopia, Ried, JS, Gieger, C, Portas, L, van Leeuwen, EM, Amin, N, Uitterlinden, AG, Rivadeneira, F, Hofman, A, Vingerling, JR, Wang, YX, Wang, X, Tai-Hui Boh, E, Ikram, MK, Sabanayagam, C, Gupta, P, Tan, V, Zhou, L, Ho, CE, Lim, W, Beuerman, RW, Siantar, R, Tai, ES, Vithana, E, Mihailov, E, Khor, CC, Hayward, C, Luben, RN, Foster, PJ, Klein, BE, Klein, R, Wong, HS, Mitchell, P, Metspalu, A, Aung, T, Young, TL, He, M, Pärssinen, O, van Duijn, CM, Jin Wang, J, Williams, C, Jonas, JB, Teo, YY, Mackey, DA, Oexle, K, Yoshimura, N, Paterson, AD, Pfeiffer, N, Wong, TY, Baird, PN, Stambolian, D, Wilson, JE, Cheng, CY, Hammond, CJ, Klaver, CC, Saw, SM, Rahi, JS, Korobelnik, JF, Kemp, JP, Timpson, NJ, Smith, GD, Craig, JE, Burdon, KP, Fogarty, RD, Iyengar, SK, Chew, E, Janmahasatian, S, Martin, NG, MacGregor, S, Xu, L, Schache, M, Nangia, V, Panda-Jonas, S, Wright, AF, Fondran, JR, Lass, JH, Feng, S, Zhao, JH, Khaw, KT, Wareham, NJ, Rantanen, T, Kaprio, J, Pang, CP, Chen, LJ, Tam, PO, Jhanji, V, Young, AL, Döring, A, Raffel, LJ, Cotch, MF, Li, X, Yip, SP, Yap, MK, Biino, G, Vaccargiu, S, Fossarello, M, Fleck, B, Yazar, S, Tideman, JW, Tedja, M, Deangelis, MM, Morrison, M, Farrer, L, Zhou, X, Chen, W, Mizuki, N, Meguro, A, Mäkelä, KM. Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat Commun 2016; 7 : 11008. PubMed PMID:27020472 PubMed Central PMC4820539.
  8. Sobota, RS, Stein, CM, Kodaman, N, Scheinfeldt, LB, Maro, I, Wieland-Alter, W, Igo, RP Jr, Magohe, A, Malone, LL, Chervenak, K, Hall, NB, Modongo, C, Zetola, N, Matee, M, Joloba, M, Froment, A, Nyambo, TB, Moore, JH, Scott, WK, Lahey, T, Boom, WH, von Reyn, CF, Tishkoff, SA, Sirugo, G, Williams, SM. A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals. Am. J. Hum. Genet. 2016; 98 (3): 514-24. PubMed PMID:26942285 PubMed Central PMC4800052.
  9. Bailey, JN, Loomis, SJ, Kang, JH, Allingham, RR, Gharahkhani, P, Khor, CC, Burdon, KP, Aschard, H, Chasman, DI, Igo, RP Jr, Hysi, PG, Glastonbury, CA, Ashley-Koch, A, Brilliant, M, Brown, AA, Budenz, DL, Buil, A, Cheng, CY, Choi, H, Christen, WG, Curhan, G, De Vivo, I, Fingert, JH, Foster, PJ, Fuchs, C, Gaasterland, D, Gaasterland, T, Hewitt, AW, Hu, F, Hunter, DJ, Khawaja, AP, Lee, RK, Li, Z, Lichter, PR, Mackey, DA, McGuffin, P, Mitchell, P, Moroi, SE, Perera, SA, Pepper, KW, Qi, Q, Realini, T, Richards, JE, Ridker, PM, Rimm, E, Ritch, R, Ritchie, M, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Song, YE, Tamimi, RM, Topouzis, F, Viswanathan, AC, Verma, SS, Vollrath, D, Wang, JJ, Weisschuh, N, Wissinger, B, Wollstein, G, Wong, TY, Yaspan, BL, Zack, DJ, Zhang, K, Study, EN, ANZRAG Consortium, Weinreb, RN, Pericak-Vance, MA, Small, K, Hammond, CJ, Aung, T, Liu, Y, Vithana, EN, MacGregor, S, Craig, JE, Kraft, P, Howell, G, Hauser, MA, Pasquale, LR, Haines, JL, Wiggs, JL. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat. Genet. 2016; 48 (2): 189-94. PubMed PMID:26752265 PubMed Central PMC4731307.
  10. Fritsche, LG, Igl, W, Bailey, JN, Grassmann, F, Sengupta, S, Bragg-Gresham, JL, Burdon, KP, Hebbring, SJ, Wen, C, Gorski, M, Kim, IK, Cho, D, Zack, D, Souied, E, Scholl, HP, Bala, E, Lee, KE, Hunter, DJ, Sardell, RJ, Mitchell, P, Merriam, JE, Cipriani, V, Hoffman, JD, Schick, T, Lechanteur, YT, Guymer, RH, Johnson, MP, Jiang, Y, Stanton, CM, Buitendijk, GH, Zhan, X, Kwong, AM, Boleda, A, Brooks, M, Gieser, L, Ratnapriya, R, Branham, KE, Foerster, JR, Heckenlively, JR, Othman, MI, Vote, BJ, Liang, HH, Souzeau, E, McAllister, IL, Isaacs, T, Hall, J, Lake, S, Mackey, DA, Constable, IJ, Craig, JE, Kitchner, TE, Yang, Z, Su, Z, Luo, H, Chen, D, Ouyang, H, Flagg, K, Lin, D, Mao, G, Ferreyra, H, Stark, K, von Strachwitz, CN, Wolf, A, Brandl, C, Rudolph, G, Olden, M, Morrison, MA, Morgan, DJ, Schu, M, Ahn, J, Silvestri, G, Tsironi, EE, Park, KH, Farrer, LA, Orlin, A, Brucker, A, Li, M, Curcio, CA, Mohand-Saïd, S, Sahel, JA, Audo, I, Benchaboune, M, Cree, AJ, Rennie, CA, Goverdhan, SV, Grunin, M, Hagbi-Levi, S, Campochiaro, P, Katsanis, N, Holz, FG, Blond, F, Blanché, H, Deleuze, JF, Igo, RP Jr, Truitt, B, Peachey, NS, Meuer, SM, Myers, CE, Moore, EL, Klein, R, Hauser, MA, Postel, EA, Courtenay, MD, Schwartz, SG, Kovach, JL, Scott, WK, Liew, G, Tan, AG, Gopinath, B, Merriam, JC, Smith, RT, Khan, JC, Shahid, H, Moore, AT, McGrath, JA, Laux, R, Brantley, MA Jr, Agarwal, A, Ersoy, L, Caramoy, A, Langmann, T, Saksens, NT, de Jong, EK, Hoyng, CB, Cain, MS, Richardson, AJ, Martin, TM, Blangero, J, Weeks, DE, Dhillon, B, van Duijn, CM, Doheny, KF, Romm, J, Klaver, CC, Hayward, C, Gorin, MB, Klein, ML, Baird, PN, den Hollander, AI, Fauser, S, Yates, JR, Allikmets, R, Wang, JJ, Schaumberg, DA, Klein, BE, Hagstrom, SA, Chowers, I, Lotery, AJ, Léveillard, T, Zhang, K, Brilliant, MH, Hewitt, AW, Swaroop, A, Chew, EY, Pericak-Vance, MA, DeAngelis, M, Stambolian, D, Haines, JL, Iyengar, SK, Weber, BH, Abecasis, GR, Heid, IM. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat. Genet. 2016; 48 (2): 134-43. PubMed PMID:26691988 PubMed Central PMC4745342.
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