xiaofeng_zhu_cropped

Xiaofeng Zhu, PhD

Professor

xxz10@case.edu | 216.368.0201 | Wolstein Research Bldg. Rm. 1317

Education

Ph.D. Biostatistics, Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 1998
M.S. Statistics, University of Cincinnati, Cincinnati, Ohio,1994
M.S. Mathematics, Peking University, Beijing, China, 1989
B.Sc. Mathematics, Peking University, Beijing, China, 1986

Research Interests

Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping.

Professional Memberships

The American Society of Human Genetics
The International Genetic Epidemiology Society
Fellow, the Royal Statistical Society

Recent Publications

  1. Liang, J, Le, TH, Edwards, DRV, Tayo, BO, Gaulton, KJ, Smith, JA, Lu, Y, Jensen, RA, Chen, G, Yanek, LR, Schwander, K, Tajuddin, SM, Sofer, T, Kim, W, Kayima, J, McKenzie, CA, Fox, E, Nalls, MA, Young, JH, Sun, YV, Lane, JM, Cechova, S, Zhou, J, Tang, H, Fornage, M, Musani, SK, Wang, H, Lee, J, Adeyemo, A, Dreisbach, AW, Forrester, T, Chu, PL, Cappola, A, Evans, MK, Morrison, AC, Martin, LW, Wiggins, KL, Hui, Q, Zhao, W, Jackson, RD, Ware, EB, Faul, JD, Reiner, AP, Bray, M, Denny, JC, Mosley, TH, Palmas, W, Guo, X, Papanicolaou, GJ, Penman, AD, Polak, JF, Rice, K, Taylor, KD, Boerwinkle, E, Bottinger, EP, Liu, K, Risch, N, Hunt, SC, Kooperberg, C, Zonderman, AB, Laurie, CC, Becker, DM, Cai, J, Loos, RJF, Psaty, BM, Weir, DR, Kardia, SLR, Arnett, DK, Won, S, Edwards, TL, Redline, S, Cooper, RS, Rao, DC, Rotter, JI, Rotimi, C, Levy, D, Chakravarti, A, Zhu, X, Franceschini, N. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. PLoS Genet. 2017; 13 (5): e1006728. PubMed PMID:28498854 PubMed Central PMC5446189.
  2. Ng, MCY, Graff, M, Lu, Y, Justice, AE, Mudgal, P, Liu, CT, Young, K, Yanek, LR, Feitosa, MF, Wojczynski, MK, Rand, K, Brody, JA, Cade, BE, Dimitrov, L, Duan, Q, Guo, X, Lange, LA, Nalls, MA, Okut, H, Tajuddin, SM, Tayo, BO, Vedantam, S, Bradfield, JP, Chen, G, Chen, WM, Chesi, A, Irvin, MR, Padhukasahasram, B, Smith, JA, Zheng, W, Allison, MA, Ambrosone, CB, Bandera, EV, Bartz, TM, Berndt, SI, Bernstein, L, Blot, WJ, Bottinger, EP, Carpten, J, Chanock, SJ, Chen, YI, Conti, DV, Cooper, RS, Fornage, M, Freedman, BI, Garcia, M, Goodman, PJ, Hsu, YH, Hu, J, Huff, CD, Ingles, SA, John, EM, Kittles, R, Klein, E, Li, J, McKnight, B, Nayak, U, Nemesure, B, Ogunniyi, A, Olshan, A, Press, MF, Rohde, R, Rybicki, BA, Salako, B, Sanderson, M, Shao, Y, Siscovick, DS, Stanford, JL, Stevens, VL, Stram, A, Strom, SS, Vaidya, D, Witte, JS, Yao, J, Zhu, X, Ziegler, RG, Zonderman, AB, Adeyemo, A, Ambs, S, Cushman, M, Faul, JD, Hakonarson, H, Levin, AM, Nathanson, KL, Ware, EB, Weir, DR, Zhao, W, Zhi, D, Bone Mineral Density in Childhood Study (BMDCS) Group, Arnett, DK, Grant, SFA, Kardia, SLR, Oloapde, OI, Rao, DC, Rotimi, CN, Sale, MM, Williams, LK, Zemel, BS, Becker, DM, Borecki, IB, Evans, MK, Harris, TB, Hirschhorn, JN, Li, Y, Patel, SR, Psaty, BM, Rotter, JI, Wilson, JG, Bowden, DW, Cupples, LA, Haiman, CA, Loos, RJF, North, KE. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet. 2017; 13 (4): e1006719. PubMed PMID:28430825 PubMed Central PMC5419579.
  3. He, KY, Wang, H, Cade, BE, Nandakumar, P, Giri, A, Ware, EB, Haessler, J, Liang, J, Smith, JA, Franceschini, N, Le, TH, Kooperberg, C, Edwards, TL, Kardia, SL, Lin, X, Chakravarti, A, Redline, S, Zhu, X. Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure. PLoS Genet. 2017; 13 (3): e1006678. PubMed PMID:28346479 PubMed Central PMC5386302.
  4. Lane, JM, Liang, J, Vlasac, I, Anderson, SG, Bechtold, DA, Bowden, J, Emsley, R, Gill, S, Little, MA, Luik, AI, Loudon, A, Scheer, FA, Purcell, SM, Kyle, SD, Lawlor, DA, Zhu, X, Redline, S, Ray, DW, Rutter, MK, Saxena, R. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat. Genet. 2017; 49 (2): 274-281. PubMed PMID:27992416 PubMed Central PMC5491693.
  5. Wang, H, Choi, Y, Tayo, B, Wang, X, Morris, N, Zhang, X, Broeckel, U, Hanis, C, Kardia, S, Redline, S, Cooper, RS, Tang, H, Zhu, X. Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Genet. Epidemiol. 2017; 41 (2): 122-135. PubMed PMID:27917522 PubMed Central PMC5226866.
  6. Wang, H, Cade, BE, Chen, H, Gleason, KJ, Saxena, R, Feng, T, Larkin, EK, Vasan, RS, Lin, H, Patel, SR, Tracy, RP, Liu, Y, Gottlieb, DJ, Below, JE, Hanis, CL, Petty, LE, Sunyaev, SR, Frazier-Wood, AC, Rotter, JI, Post, W, Lin, X, Redline, S, Zhu, X. Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level. Hum. Mol. Genet. 2016; 25 (23): 5244-5253. PubMed PMID:27798093 .
  7. Park, H, Li, X, Song, YE, He, KY, Zhu, X. Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium. PLoS ONE 2016; 11 (10): e0163912. PubMed PMID:27701450 PubMed Central PMC5049793.
  8. Ehret, GB, Ferreira, T, Chasman, DI, Jackson, AU, Schmidt, EM, Johnson, T, Thorleifsson, G, Luan, J, Donnelly, LA, Kanoni, S, Petersen, AK, Pihur, V, Strawbridge, RJ, Shungin, D, Hughes, MF, Meirelles, O, Kaakinen, M, Bouatia-Naji, N, Kristiansson, K, Shah, S, Kleber, ME, Guo, X, Lyytikäinen, LP, Fava, C, Eriksson, N, Nolte, IM, Magnusson, PK, Salfati, EL, Rallidis, LS, Theusch, E, Smith, AJP, Folkersen, L, Witkowska, K, Pers, TH, Joehanes, R, Kim, SK, Lataniotis, L, Jansen, R, Johnson, AD, Warren, H, Kim, YJ, Zhao, W, Wu, Y, Tayo, BO, Bochud, M, CHARGE-EchoGen consortium, CHARGE-HF consortium, Wellcome Trust Case Control Consortium, Absher, D, Adair, LS, Amin, N, Arking, DE, Axelsson, T, Baldassarre, D, Balkau, B, Bandinelli, S, Barnes, MR, Barroso, I, Bevan, S, Bis, JC, Bjornsdottir, G, Boehnke, M, Boerwinkle, E, Bonnycastle, LL, Boomsma, DI, Bornstein, SR, Brown, MJ, Burnier, M, Cabrera, CP, Chambers, JC, Chang, IS, Cheng, CY, Chines, PS, Chung, RH, Collins, FS, Connell, JM, Döring, A, Dallongeville, J, Danesh, J, de Faire, U, Delgado, G, Dominiczak, AF, Doney, ASF, Drenos, F, Edkins, S, Eicher, JD, Elosua, R, Enroth, S, Erdmann, J, Eriksson, P, Esko, T, Evangelou, E, Evans, A, Fall, T, Farrall, M, Felix, JF, Ferrières, J, Ferrucci, L, Fornage, M, Forrester, T, Franceschini, N, Duran, OHF, Franco-Cereceda, A, Fraser, RM, Ganesh, SK, Gao, H, Gertow, K, Gianfagna, F, Gigante, B, Giulianini, F, Goel, A, Goodall, AH, Goodarzi, MO, Gorski, M, Gräßler, J, Groves, C, Gudnason, V, Gyllensten, U, Hallmans, G, Hartikainen, AL, Hassinen, M, Havulinna, AS, Hayward, C, Hercberg, S, Herzig, KH, Hicks, AA, Hingorani, AD, Hirschhorn, JN, Hofman, A, Holmen, J, Holmen, OL, Hottenga, JJ, Howard, P, Hsiung, CA, Hunt, SC, Ikram, MA, Illig, T, Iribarren, C, Jensen, RA, Kähönen, M, Kang, H, Kathiresan, S, Keating, BJ, Khaw, KT, Kim, YK, Kim, E, Kivimaki, M, Klopp, N, Kolovou, G, Komulainen, P, Kooner, JS, Kosova, G, Krauss, RM, Kuh, D, Kutalik, Z, Kuusisto, J, Kvaløy, K, Lakka, TA, Lee, NR, Lee, IT, Lee, WJ, Levy, D, Li, X, Liang, KW, Lin, H, Lin, L, Lindström, J, Lobbens, S, Männistö, S, Müller, G, Müller-Nurasyid, M, Mach, F, Markus, HS, Marouli, E, McCarthy, MI, McKenzie, CA, Meneton, P, Menni, C, Metspalu, A, Mijatovic, V, Moilanen, L, Montasser, ME, Morris, AD, Morrison, AC, Mulas, A, Nagaraja, R, Narisu, N, Nikus, K, O'Donnell, CJ, O'Reilly, PF, Ong, KK, Paccaud, F, Palmer, CD, Parsa, A, Pedersen, NL, Penninx, BW, Perola, M, Peters, A, Poulter, N, Pramstaller, PP, Psaty, BM, Quertermous, T, Rao, DC, Rasheed, A, Rayner, NWNWR, Renström, F, Rettig, R, Rice, KM, Roberts, R, Rose, LM, Rossouw, J, Samani, NJ, Sanna, S, Saramies, J, Schunkert, H, Sebert, S, Sheu, WH, Shin, YA, Sim, X, Smit, JH, Smith, AV, Sosa, MX, Spector, TD, Stančáková, A, Stanton, A, Stirrups, KE, Stringham, HM, Sundstrom, J, Swift, AJ, Syvänen, AC, Tai, ES, Tanaka, T, Tarasov, KV, Teumer, A, Thorsteinsdottir, U, Tobin, MD, Tremoli, E, Uitterlinden, AG, Uusitupa, M, Vaez, A, Vaidya, D, van Duijn, CM, van Iperen, EPA, Vasan, RS, Verwoert, GC, Virtamo, J, Vitart, V, Voight, BF, Vollenweider, P, Wagner, A, Wain, LV, Wareham, NJ, Watkins, H, Weder, AB, Westra, HJ, Wilks, R, Wilsgaard, T, Wilson, JF, Wong, TY, Yang, TP, Yao, J, Yengo, L, Zhang, W, Zhao, JH, Zhu, X, Bovet, P, Cooper, RS, Mohlke, KL, Saleheen, D, Lee, JY, Elliott, P, Gierman, HJ, Willer, CJ, Franke, L, Hovingh, GK, Taylor, KD, Dedoussis, G, Sever, P, Wong, A, Lind, L, Assimes, TL, Njølstad, I, Schwarz, PE, Langenberg, C, Snieder, H, Caulfield, MJ, Melander, O, Laakso, M, Saltevo, J, Rauramaa, R, Tuomilehto, J, Ingelsson, E, Lehtimäki, T, Hveem, K, Palmas, W, März, W, Kumari, M, Salomaa, V, Chen, YI, Rotter, JI, Froguel, P, Jarvelin, MR, Lakatta, EG, Kuulasmaa, K, Franks, PW, Hamsten, A, Wichmann, HE, Palmer, CNA, Stefansson, K, Ridker, PM, Loos, RJF, Chakravarti, A, Deloukas, P, Morris, AP, Newton-Cheh, C, Munroe, PB. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat. Genet. 2016; 48 (10): 1171-1184. PubMed PMID:27618452 PubMed Central PMC5042863.
  9. Liu, CT, Raghavan, S, Maruthur, N, Kabagambe, EK, Hong, J, Ng, MC, Hivert, MF, Lu, Y, An, P, Bentley, AR, Drolet, AM, Gaulton, KJ, Guo, X, Armstrong, LL, Irvin, MR, Li, M, Lipovich, L, Rybin, DV, Taylor, KD, Agyemang, C, Palmer, ND, Cade, BE, Chen, WM, Dauriz, M, Delaney, JA, Edwards, TL, Evans, DS, Evans, MK, Lange, LA, Leong, A, Liu, J, Liu, Y, Nayak, U, Patel, SR, Porneala, BC, Rasmussen-Torvik, LJ, Snijder, MB, Stallings, SC, Tanaka, T, Yanek, LR, Zhao, W, Becker, DM, Bielak, LF, Biggs, ML, Bottinger, EP, Bowden, DW, Chen, G, Correa, A, Couper, DJ, Crawford, DC, Cushman, M, Eicher, JD, Fornage, M, Franceschini, N, Fu, YP, Goodarzi, MO, Gottesman, O, Hara, K, Harris, TB, Jensen, RA, Johnson, AD, Jhun, MA, Karter, AJ, Keller, MF, Kho, AN, Kizer, JR, Krauss, RM, Langefeld, CD, Li, X, Liang, J, Liu, S, Lowe, WL Jr, Mosley, TH, North, KE, Pacheco, JA, Peyser, PA, Patrick, AL, Rice, KM, Selvin, E, Sims, M, Smith, JA, Tajuddin, SM, Vaidya, D, Wren, MP, Yao, J, Zhu, X, Ziegler, JT, Zmuda, JM, Zonderman, AB, Zwinderman, AH, AAAG Consortium, CARe Consortium, COGENT-BP Consortium, eMERGE Consortium, MEDIA Consortium, Adeyemo, A, Boerwinkle, E, Ferrucci, L, Hayes, MG, Kardia, SL, Miljkovic, I, Pankow, JS, Rotimi, CN, Sale, MM, Wagenknecht, LE, Arnett, DK, Chen, YD, Nalls, MA, MAGIC Consortium, Province, MA, Kao, WH, Siscovick, DS, Psaty, BM, Wilson, JG, Loos, RJ, Dupuis, J, Rich, SS, Florez, JC, Rotter, JI, Morris, AP, Meigs, JB. Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am. J. Hum. Genet. 2016; 99 (1): 56-75. PubMed PMID:27321945 PubMed Central PMC5005440.
  10. Sung, YJ, Winkler, TW, Manning, AK, Aschard, H, Gudnason, V, Harris, TB, Smith, AV, Boerwinkle, E, Brown, MR, Morrison, AC, Fornage, M, Lin, LA, Richard, M, Bartz, TM, Psaty, BM, Hayward, C, Polasek, O, Marten, J, Rudan, I, Feitosa, MF, Kraja, AT, Province, MA, Deng, X, Fisher, VA, Zhou, Y, Bielak, LF, Smith, J, Huffman, JE, Padmanabhan, S, Smith, BH, Ding, J, Liu, Y, Lohman, K, Bouchard, C, Rankinen, T, Rice, TK, Arnett, D, Schwander, K, Guo, X, Palmas, W, Rotter, JI, Alfred, T, Bottinger, EP, Loos, RJ, Amin, N, Franco, OH, van Duijn, CM, Vojinovic, D, Chasman, DI, Ridker, PM, Rose, LM, Kardia, S, Zhu, X, Rice, K, Borecki, IB, Rao, DC, Gauderman, WJ, Cupples, LA. An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. Genet. Epidemiol. 2016; 40 (5): 404-15. PubMed PMID:27230302 PubMed Central PMC4911246.
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