jonathan_cropped

Jonathan L. Haines, PhD

Mary W. Sheldon MD Professor of Genomic Sciences, Chair

jonathan.haines@case.edu | 216.368.2478 | Wolstein Research Bldg., Rm 2528

Education

Recent Publications

  1. Huang, KL, Marcora, E, Pimenova, AA, Di Narzo, AF, Kapoor, M, Jin, SC, Harari, O, Bertelsen, S, Fairfax, BP, Czajkowski, J, Chouraki, V, Grenier-Boley, B, Bellenguez, C, Deming, Y, McKenzie, A, Raj, T, Renton, AE, Budde, J, Smith, A, Fitzpatrick, A, Bis, JC, DeStefano, A, Adams, HHH, Ikram, MA, van der Lee, S, Del-Aguila, JL, Fernandez, MV, Ibañez, L, International Genomics of Alzheimer's Project, Alzheimer's Disease Neuroimaging Initiative, Sims, R, Escott-Price, V, Mayeux, R, Haines, JL, Farrer, LA, Pericak-Vance, MA, Lambert, JC, van Duijn, C, Launer, L, Seshadri, S, Williams, J, Amouyel, P, Schellenberg, GD, Zhang, B, Borecki, I, Kauwe, JSK, Cruchaga, C, Hao, K, Goate, AM. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nat. Neurosci. 2017; : . PubMed PMID:28628103 .
  2. Aung, T, Ozaki, M, Lee, MC, Schlötzer-Schrehardt, U, Thorleifsson, G, Mizoguchi, T, Igo, RP Jr, Haripriya, A, Williams, SE, Astakhov, YS, Orr, AC, Burdon, KP, Nakano, S, Mori, K, Abu-Amero, K, Hauser, M, Li, Z, Prakadeeswari, G, Bailey, JNC, Cherecheanu, AP, Kang, JH, Nelson, S, Hayashi, K, Manabe, SI, Kazama, S, Zarnowski, T, Inoue, K, Irkec, M, Coca-Prados, M, Sugiyama, K, Järvelä, I, Schlottmann, P, Lerner, SF, Lamari, H, Nilgün, Y, Bikbov, M, Park, KH, Cha, SC, Yamashiro, K, Zenteno, JC, Jonas, JB, Kumar, RS, Perera, SA, Chan, ASY, Kobakhidze, N, George, R, Vijaya, L, Do, T, Edward, DP, de Juan Marcos, L, Pakravan, M, Moghimi, S, Ideta, R, Bach-Holm, D, Kappelgaard, P, Wirostko, B, Thomas, S, Gaston, D, Bedard, K, Greer, WL, Yang, Z, Chen, X, Huang, L, Sang, J, Jia, H, Jia, L, Qiao, C, Zhang, H, Liu, X, Zhao, B, Wang, YX, Xu, L, Leruez, S, Reynier, P, Chichua, G, Tabagari, S, Uebe, S, Zenkel, M, Berner, D, Mossböck, G, Weisschuh, N, Hoja, U, Welge-Luessen, UC, Mardin, C, Founti, P, Chatzikyriakidou, A, Pappas, T, Anastasopoulos, E, Lambropoulos, A, Ghosh, A, Shetty, R, Porporato, N, Saravanan, V, Venkatesh, R, Shivkumar, C, Kalpana, N, Sarangapani, S, Kanavi, MR, Beni, AN, Yazdani, S, Lashay, A, Naderifar, H, Khatibi, N, Fea, A, Lavia, C, Dallorto, L, Rolle, T, Frezzotti, P, Paoli, D, Salvi, E, Manunta, P, Mori, Y, Miyata, K, Higashide, T, Chihara, E, Ishiko, S, Yoshida, A, Yanagi, M, Kiuchi, Y, Ohashi, T, Sakurai, T, Sugimoto, T, Chuman, H, Aihara, M, Inatani, M, Miyake, M, Gotoh, N, Matsuda, F, Yoshimura, N, Ikeda, Y, Ueno, M, Sotozono, C, Jeoung, JW, Sagong, M, Park, KH, Ahn, J, Cruz-Aguilar, M, Ezzouhairi, SM, Rafei, A, Chong, YF, Ng, XY, Goh, SR, Chen, Y, Yong, VHK, Khan, MI, Olawoye, OO, Ashaye, AO, Ugbede, I, Onakoya, A, Kizor-Akaraiwe, N, Teekhasaenee, C, Suwan, Y, Supakontanasan, W, Okeke, S, Uche, NJ, Asimadu, I, Ayub, H, Akhtar, F, Kosior-Jarecka, E, Lukasik, U, Lischinsky, I, Castro, V, Grossmann, RP, Megevand, GS, Roy, S, Dervan, E, Silke, E, Rao, A, Sahay, P, Fornero, P, Cuello, O, Sivori, D, Zompa, T, Mills, RA, Souzeau, E, Mitchell, P, Wang, JJ, Hewitt, AW, Coote, M, Crowston, JG, Astakhov, SY, Akopov, EL, Emelyanov, A, Vysochinskaya, V, Kazakbaeva, G, Fayzrakhmanov, R, Al-Obeidan, SA, Owaidhah, O, Aljasim, LA, Chowbay, B, Foo, JN, Soh, RQ, Sim, KS, Xie, Z, Cheong, AWO, Mok, SQ, Soo, HM, Chen, XY, Peh, SQ, Heng, KK, Husain, R, Ho, SL, Hillmer, AM, Cheng, CY, Escudero-Domínguez, FA, González-Sarmiento, R, Martinon-Torres, F, Salas, A, Pathanapitoon, K, Hansapinyo, L, Wanichwecharugruang, B, Kitnarong, N, Sakuntabhai, A, Nguyn, HX, Nguyn, GTT, Nguyn, TV, Zenz, W, Binder, A, Klobassa, DS, Hibberd, ML, Davila, S, Herms, S, Nöthen, MM, Moebus, S, Rautenbach, RM, Ziskind, A, Carmichael, TR, Ramsay, M, Álvarez, L, García, M, González-Iglesias, H, Rodríguez-Calvo, PP, Cueto, LF, Oguz, Ç, Tamcelik, N, Atalay, E, Batu, B, Aktas, D, Kasım, B, Wilson, MR, Coleman, AL, Liu, Y, Challa, P, Herndon, L, Kuchtey, RW, Kuchtey, J, Curtin, K, Chaya, CJ, Crandall, A, Zangwill, LM, Wong, TY, Nakano, M, Kinoshita, S, den Hollander, AI, Vesti, E, Fingert, JH, Lee, RK, Sit, AJ, Shingleton, BJ, Wang, N, Cusi, D, Qamar, R, Kraft, P, Pericak-Vance, MA, Raychaudhuri, S, Heegaard, S, Kivelä, T, Reis, A, Kruse, FE, Weinreb, RN, Pasquale, LR, Haines, JL, Thorsteinsdottir, U, Jonasson, F, Allingham, RR, Milea, D, Ritch, R, Kubota, T, Tashiro, K, Vithana, EN, Micheal, S, Topouzis, F, Craig, JE, Dubina, M, Sundaresan, P, Stefansson, K, Wiggs, JL, Pasutto, F, Khor, CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat. Genet. 2017; : . PubMed PMID:28553957 .
  3. Kunkle, BW, Carney, RM, Kohli, MA, Naj, AC, Hamilton-Nelson, KL, Whitehead, PL, Wang, L, Lang, R, Cuccaro, ML, Vance, JM, Byrd, GS, Beecham, GW, Gilbert, JR, Martin, ER, Haines, JL, Pericak-Vance, MA. Targeted sequencing of ABCA7 identifies splicing, stop-gain and intronic risk variants for Alzheimer disease. Neurosci. Lett. 2017; 649 : 124-129. PubMed PMID:28400126 .
  4. Jun, GR, Chung, J, Mez, J, Barber, R, Beecham, GW, Bennett, DA, Buxbaum, JD, Byrd, GS, Carrasquillo, MM, Crane, PK, Cruchaga, C, De Jager, P, Ertekin-Taner, N, Evans, D, Fallin, MD, Foroud, TM, Friedland, RP, Goate, AM, Graff-Radford, NR, Hendrie, H, Hall, KS, Hamilton-Nelson, KL, Inzelberg, R, Kamboh, MI, Kauwe, JS, Kukull, WA, Kunkle, BW, Kuwano, R, Larson, EB, Logue, MW, Manly, JJ, Martin, ER, Montine, TJ, Mukherjee, S, Naj, A, Reiman, EM, Reitz, C, Sherva, R, St George-Hyslop, PH, Thornton, T, Younkin, SG, Vardarajan, BN, Wang, LS, Wendlund, JR, Winslow, AR, Alzheimer's Disease Genetics Consortium, Haines, J, Mayeux, R, Pericak-Vance, MA, Schellenberg, G, Lunetta, KL, Farrer, LA. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 2017; : . PubMed PMID:28183528 .
  5. Balasubramanian, S, Lei, J, Nittala, MG, Velaga, SB, Haines, J, Pericak-Vance, MA, Stambolian, D, Sadda, SR. ASSOCIATION OF DRUSEN VOLUME WITH CHOROIDAL PARAMETERS IN NONNEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina (Philadelphia, Pa.) 2017; : . PubMed PMID:28169876 .
  6. Butkiewicz, M, Haines, JL, Bush, WS. Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants. Bioinformatics 2017; 33 (10): 1561-1562. PubMed PMID:28122779 PubMed Central PMC5423451.
  7. Haddick, PC, Larson, JL, Rathore, N, Bhangale, TR, Phung, QT, Srinivasan, K, Hansen, DV, Lill, JR, Alzheimer’s Disease Genetic Consortium (ADGC), Alzheimer’s Disease Neuroimaging Initiative (ADNI), Pericak-Vance, MA, Haines, J, Farrer, LA, Kauwe, JS, Schellenberg, GD, Cruchaga, C, Goate, AM, Behrens, TW, Watts, RJ, Graham, RR, Kaminker, JS, van der Brug, M. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. J. Alzheimers Dis. 2017; 56 (3): 1037-1054. PubMed PMID:28106546 .
  8. Miskimen, KL, Chan, ER, Haines, JL. Assay for Transposase-Accessible Chromatin Using Sequencing (ATAC-seq) Data Analysis. Curr Protoc Hum Genet 2017; 92 : 20.4.1-20.4.13. PubMed PMID:28075484 .
  9. Springelkamp, H, Iglesias, AI, Mishra, A, Höhn, R, Wojciechowski, R, Khawaja, AP, Nag, A, Wang, YX, Wang, JJ, Cuellar-Partida, G, Gibson, J, Bailey, JN, Vithana, EN, Gharahkhani, P, Boutin, T, Ramdas, WD, Zeller, T, Luben, RN, Yonova-Doing, E, Viswanathan, AC, Yazar, S, Cree, AJ, Haines, JL, Koh, JY, Souzeau, E, Wilson, JF, Amin, N, Müller, C, Venturini, C, Kearns, LS, Kang, JH, NEIGHBORHOOD Consortium, Tham, YC, Zhou, T, van Leeuwen, EM, Nickels, S, Sanfilippo, P, Liao, J, van der Linde, H, Zhao, W, van Koolwijk, LM, Zheng, L, Rivadeneira, F, Baskaran, M, van der Lee, SJ, Perera, S, de Jong, PT, Oostra, BA, Uitterlinden, AG, Fan, Q, Hofman, A, Tai, ES, Vingerling, JR, Sim, X, Wolfs, RC, Teo, YY, Lemij, HG, Khor, CC, Willemsen, R, Lackner, KJ, Aung, T, Jansonius, NM, Montgomery, G, Wild, PS, Young, TL, Burdon, KP, Hysi, PG, Pasquale, LR, Wong, TY, Klaver, CC, Hewitt, AW, Jonas, JB, Mitchell, P, Lotery, AJ, Foster, PJ, Vitart, V, Pfeiffer, N, Craig, JE, Mackey, DA, Hammond, CJ, Wiggs, JL, Cheng, CY, van Duijn, CM, MacGregor, S. New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum. Mol. Genet. 2017; 26 (2): 438-453. PubMed PMID:28073927 .
  10. Sardell, RJ, Persad, PJ, Pan, SS, Whitehead, P, Adams, LD, Laux, RA, Fortun, JA, Brantley, MA Jr, Kovach, JL, Schwartz, SG, Agarwal, A, Haines, JL, Scott, WK, Pericak-Vance, MA. Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus. Invest. Ophthalmol. Vis. Sci. 2016; 57 (14): 6107-6115. PubMed PMID:27832277 PubMed Central PMC5104418.
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