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Research:
Chris Whalen
TW-00011-16 (PI - Whalen, CC)
9/03 - 8/08
NIH
AIDS International Training and Research Program
To provide intensive training in research methodology for HIV/AIDS research to foreign investigators and their colleagues and to assist in the development of the infra-structure for collaborative research.
AI51219 (PI - Whalen, CC)
2/03 - 1/08
NIH
HIV/TB in Uganda: Punctuated Antiretroviral Therapy
To determine whether a punctuated course of standard antiretroviral therapy during treatment for HIV-associated tuberculosis delays the progression to AIDS.
TW 006900-01 (PI - Whalen, CC)
2/04 - 1/09
NIH
COHRE Program in Uganda
This is a research and training program relating to clinical, operational, and health services research on tuberculosis or HIV in Uganda. Through graduate degree and non-degree training experiences based in research, the COHRE will help develop capacity in Uganda to evaluate new treatment and prevention programs for HIV and tuberculosis.
PI - Whalen, Christopher C.
3/07 - 2/09
0.6 calendar months
Doris Duke Charitable Trust
Active case finding for HIV and tuberculosis in Kampala Uganda
This is an operational research project intended to determine the most efficient and effective way to perform active case finding in an urban African setting. The study will compare operational outcomes for household contact investigations and community symptoms surveys. The analysis will consider both process and outcomes. This study is intended to inform policy regarding tuberculosis control in Africa.
NO1-AI95383 (PI - Boom H, Component leader - Whalen, CC)
12/01/99-11/30/06
NIH
Tuberculosis Research Unit (TBRU)
To conduct epidemiologic, immunologic, microbiologic studies of M. tuberculosis infection and to perform clinical trials of new immuno-therapeutic approaches, vaccines, drugs and drug treatment protocols and diagnostic tests for tuberculosis in Uganda, Brazil and Philippines.
AI36219 (PI - Lederman MM) Whalen is Co-Investigator
4/04 - 3/09
NIH
Center for AIDS Research
To promote HIV/AIDS research in multiple disciplines including basic virology, vaccine development, clinical trials of antiretroviral therapy, and international research.
1 K23 DE015746-03 (PI - Vernon L; Co-sponsor - Whalen CC)
6/04 - 8/09
NIH
Oral Link to Vascular Disease in an HIV-1 Cohort
This is a K23 career development award that will help to promote the career of the applicant through formal didactic training and a mentored research project. The research will evaluate the effect of highly active antiretroviral therapy in HIV-infected adults in the progression of vascular disease.
PI - Kauffman S;
Co-investigator - Whalen CC
07/01/05 - 06/30/10
Grand Challenges in Global Health
Gates Foundation
Biomarkers of protective immunity and surrogate markers of TB disease in Africa
The objectives are to define biomarkers and signature profiles of innate and adaptive immune response against M. tuberculosis, which are associated with protection against TB. Molecular and immunological tools will be used to study the host response to M. tuberculosis infection in individuals, with or without HIV-1/AIDS, from 5 different countries across the African continent: The Gambia, Ethiopia, Uganda, Malawi, and South Africa.
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Ajay Sethi
1RO3AA015488 (PI - Sethi, AK)
8/2005 - 7/2007
Population-based study of alcohol, HIV, & TB in Uganda
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
This study aims to develop and validate a culturally appropriate instrument of alcohol consumption in the Kawempe Division of Kampala, Uganda. This instrument will be utilized to study patterns of alcohol consumption and its relationship to HIV and TB prevalence in a population-based sample.
2007012 (PI - Sethi AK)
5/15/2007 - 4/14/2009
Mobile ARV pharmacy at TREAT sites in rural Uganda
Doris Duke Charitable Foundation; 2007 Operations Research on AIDS Care and Treatment in Africa (ORACTA) Award
In Uganda, pharmacies are hospital-based, and HIV-infected patients must travel monthly to the hospital to obtain ARV refills. Patients residing in rural districts have to travel long distances. When treatment is initiated, trips may be 1-2 weeks apart. Over time, visits are paired with ARV refill times and become monthly whether or not patients are symptomatic. The result is overcrowding, increased wait time, reduced doctor-patient time, and potential for non-adherence if patients begin to perceive adherence to ARVs as requiring inconvenient and arduous trips to the clinic. To relieve this burden and in response to preliminary data, we propose to integrate a mobile ARV pharmacy into HIV care at rural TREAT sites. This study has three aims: 1. To identify patients eligible for receiving ARVs via a mobile pharmacy at rural TREAT sites in Uganda; 2. To implement and determine the feasibility of a mobile ARV pharmacy for rural HIV-infected residents; 3. To evaluate the effectiveness of a mobile ARV pharmacy in rural Uganda using quantified and qualitative measures.
Center for AIDS Research Developmental Award (PI - Sethi, AK)
3/2005 - 4/2008
Development of Simple Tools to Assess ART Adherence in Uganda
National Institutes of Health
Uganda met and exceeded its goal to treat 60,000 HIV-infected individuals with antiretroviral (ARV) therapy by the end of 2005 in accordance with the World Health Organization (WHO) 3 by 5 Initiative. The success and longevity of Uganda?s ARV program will be depend on the ability of patients to maintain high-level adherence to avoid the development of widespread drug resistance. This is especially important in rural Uganda where resources are limited, where culture is distinct, and to where the HIV epidemic is shifting. There are no standard methods to assess adherence in clinic settings much less ones that are culture-specific. The goal of the proposed study is to adapt and validate simple ARV adherence tools based on and developed from previous research.
5P30AI036219-12 (PI - Lederman, MM) Sethi is Core F (Epidemiology and Biostatistics) Investigator
4/2004 - 3/2009
Center for AIDS Research
National Institutes of Health
Promotes increased collaboration between basic and clinical researchers through a central administrative structure, development of appropriate forums for sharing and exchange of ideas and pilot funding for interdisciplinary research. Also to enhance the depth and breadth of AIDS research by coordinated development of core activities and recruitment of new investigators.
TW-00011-16 (PI - Whalen, CC)
Role: Training Grant Faculty
9/2003 - 8/2008
AIDS International Training and Research Program
National Institutes of Health
To provide intensive training in research methodology for HIV/AIDS research to foreign investigators and their colleagues and to assist in the development of the infra-structure for collaborative research.
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Daniel Tisch
1U19AI065717-02 (J Kazura, Program Director, Tisch is PI of Core B))
8/15/05-4/30/10
NIAID
Core B Data Management and Biostatistics Core. International Collaboration in Infectious Disease Research (ICIDR). Mass drug treatment and vector control of filariasis
The long-term goals of this multi-project ICIDR application are to advance knowledge of human, parasite and mosquito variables and related implementation and policy issues that will inform and enhance success of controlling disease morbidity and permanently stopping transmission of the filarial parasite Wuchereria bancrofti in Papua New Guinea, and by extension, other areas where lymphatic filariasis is endemic.
1 D43 TW007377-02 (P Zimmerman, Program Director, Tisch is Co-Investigator)
7/26/05-3/31/10
FIC
CASE-PNG Infectious Disease Research Training Program: Global Infectious Disease Research Training Program
This application represents a new effort to develop a collaborative training program in infectious disease research between Case Western Reserve University and the Papua New Guinea Institute of Medical Research.
1R25 TW07735-01 (Tisch is Co-Investigator)
9/15/06-8/31/09
FIC/NIH
Framework Programs in Global Health: ?Integrated Programs & Curricula for Global Health Education
The overall goal of this program is to interest and retain undergraduate, graduate and professional students in international health related careers by expanding the perception of potential relevant fields, facilitating interdisciplinary study and providing opportunities for applied experiences.
1R01TW007872-01 (P Zimmerman, PI, Tisch is Co-Investigator)
9/15/06-8/31/11
FIC
Changing dynamics of anopholene transmission of malaria?
This study proposes to provide insight into the fine- and medium-scale factors that contribute to village-by-village risk differences for mosquito-borne parasite transmission. It will also include refinement of strategies for monitoring and implementing control of mosquito-borne transmission of malaria and filaria in Papua New Guinea.
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Catherine M. Stein
KL2RR024990 (Rudick, R, PI; Stein is Clinical Research Scholar)
9/23/2004 - 07/31/2009
NIH/NCRR
Case/Cleveland Clinic Clinical Research Training Program
This program is a collaboration involving Case Western Reserve University (CWRU), Cleveland Clinic, University Hospitals of Cleveland, MetroHealth Medical Center, and Cleveland VA Medical Center. The K12 program will uniquely position each CR Scholar for a leadership role in academic medicine, industry, or government as an independent clinical investigator.
STERIS Corporation Pilot Grant (Stein, PI)
06/01/07-05/31/08
Identification of novel tuberculosis susceptibility genes through a genome scan
This is a small pilot study to fine map novel regions linked to tuberculosis phenotypes as identified through a full genome scan.
N01-AI 95383 (Boom, WH, PI; Stein is Genetics Working Group Leader and Co-investigator)
05/01/07-04/30/14
NIH/NIAID
Tuberculosis Research Unit (TBRU)
The TBRU supports a multi-disciplinary, multi-national consortium of investigators and institutions with expertise in epidemiology, microbiology, and immunology to conduct clinical studies on host-pathogen interactions in tuberculosis. The goal of these studies is to fill critical gaps in translational TB research and to provide tools needed to advance TB control in TB endemic countries.
5P41 RR003655-19 (R. Elston, PI; Stein is co-investigator)
09/01/97-07/31/11
NIH/NCRR
Human Genetic Analysis Resource
The major goals of this project are to provide expertise in human genetic analysis to research workers and to develop and distribute software to facilitate the statistical identification of disease genes.
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