DEPT. OF EPIDEMIOLOGY
& BIOSTATISTICS

Courtney Gray-McGuire , PH.D. Assistant Professor, Division of Genetic Epidemiology Methods of analysis for and the study of complex human disorders, family based association methods. Office: Wolstein Research Building, Rm. 1312 Phone: (216) 368-4314 E-mail: courtney.gray-mcguire@case.edu

Education

2004, Ph.D. in Genetic and Molecular Epidemiology, Department of Epidemiology and Biostatistics, Case Western Reserve University. Cleveland, OH.  Dissertation:  Assessment of Variance Component Method for Binary Phenotype Data: Model Misspecification and Effects of Ascertainment.

2000. M.S. in Biostatistics, Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Thesis: Simulation of pedigree data for the exploration of genetic linkage to disease: power to detect linkage to a binary trait using IBD allele sharing estimates from sibpairs and the impact of non-independence.

Research Interests

In general my interests are in the study of complex genetic disorders.  Specifically, I am involved in projects on systemic lupus erythematosus, coronary heart disease, lupus, sarcoidosis and colon cancer.  I am also involved in the Human Genetic Analysis Resource, which is a research resource focused on the development of  statistical methods for analyzing family and pedigree data for the identification of genes that cause disease, implementing those methods into the program package S.A.G.E., and applying them to collaborative research in many areas.

Professional Memberships

American Society of Human Genetics
International Genetic Epidemiology Society
American Statistical Association
American Academy of Sciences

Recent Publications

Stein CM, Olson JM, Gray-McGuire C , Bruner GR, Harley JB, Moser KL. Increased prevalence of renal disease in SLE families with affected males. Arthritis Rheum . 46: 428-435, 2002.

Kelly JA, Thompson K, Kilpatrick J, Lam T, Nath SK, Gray-McGuire C , Reid J, Namjou B, Aston CE, Bruner GR, Scofield RH, Harley JB. Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia. Proc Natl Acad Sci USA . 99:11766-71, 2002.

Nath SK, Kelly JA, Reid J, Lam T, Gray-McGuire C , Aston CE, Harley JB. SLEB3 in systemic lupus erythematosus (SLE) is strongly related to SLE families ascertained through neuropsychiatric manifestations. Hum Genet , 111:54-8, 2002.

Jacobs KJ, Gray-McGuire C , Cartier KC, Elston RC. Genome linkage scan for genes affecting longitudinal changes and variability in systolic blood pressure. BMC Genet . 4 (Suppl 1):S82, 2003

Gray-McGuire C , Olson JM. Relatives-based non-parametric analysis of linkage. In: Encyclopedia of the Human Genome. Cooper DN and Thomas N (eds). Nature Publishing Group, 2004.

Elston RC, Gray-McGuire C .  A review of the "Statistical Analysis for Genetic Epidemiology" (S.A.G.E.) software program package.  Hum Genomics : 1:456-9,2004.

Larkin E, Cartier K, Gray-McGuire C A regression based transmission/disequilibrium test for binary traits: the power of joint tests for linkage and association. BMC Genet.  6 (Suppl 1) 2005.

Thompson C, Baechle D, Qing L, Mathew G, Song Y, Iyengar S, Gray-McGuire C , Goddard KAB. Effect of genotyping error in model-free linkage analysis using microsatellite or SNP marker maps. BMC Genet.  6 (Suppl 1) 2005.