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case western reserve university

DEPT. OF EPIDEMIOLOGY
& BIOSTATISTICS
 

TOMAS RADIVOYEVITCH, PH.D.

Assisstant Professor
Division of Biostatistics

Theoretical radiation biology
Biochemical system analyses of microarray data

Office: School of Medicine, BRB-G19
Phone: (216) 368-1965
E-mail: txr24@case.edu
Education
Ph.D. 1996, Medical University of South Carolina: Environmental Risk Assessment
M.S. 1992, Case Western Reserve University: Chemistry
M.S. 1987, Case Western Reserve University: Systems Engineering
B.S. 1986, Case Western Reserve University: Electrical Engineering


Research Interests
Theoretical radiation biology, biochemical system analyses of microarray data.


Positions
1986-1987        Teaching Assistant, Systems Engineering, Case, Cleveland, OH
1988-1988        Computer Programmer, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
1989-1991        Applications Engineer, Bailey Controls Company, Wickliffe, OH
1991-1992        Research Assistant, Chemistry, Case, Cleveland, OH
1992-1993        Teaching Assistant, Biochemistry, Ohio State University, Columbus, OH
1993-1996        Graduate Student, Biometry, MUSC, Charleston, SC
1997-1998        Postdoctoral Fellow, Biometry, MUSC, Charleston, SC
1998-2000        Research Instructor, Biometry, MUSC, Charleston, SC
2000-2001        Visiting Assistant Research Mathematician, University of California, Berkeley, CA
2001-present    Assistant Professor, Epidemiology and Biostatistics, Case, Cleveland, OH


Selected Peer-Reviewed Publications
T. Radivoyevitch and B. Cedervall, Mathematical analysis of DNA fragment distribution models used with pulsed field gel electrophoresis. Electrophoresis 17, 1087-1093 (1996).

B. Cedervall and T. Radivoyevitch, Methods for analysis of DNA fragment distributions on pulsed field gel electrophoretic gels. Electrophoresis 17, 1080-1086 (1996).

T. Radivoyevitch, D. G. Hoel, A. M. Chen and R. K. Sachs, Misrejoining of double-strand breaks after X-irradiation: Relating moderate to very high doses by a Markov model. Radiat. Res. 149, 59-67 (1998).

T. Radivoyevitch, D. G. Hoel, P. Hahnfeldt, B. Rydberg and R. K. Sachs, Recent data obtained by pulsed-field gel electrophoresis suggest two types of double-strand breaks. Radiat. Res. 149, 52-58 (1998).

T. Radivoyevitch, D. G. Hoel, P. Hahnfeldt and R. K. Sachs, Size distributions of misrejoining DNA fragments in irradiated cells. Math. Biosci. 149, 107-136 (1998).

T. Radivoyevitch, M. J. Ramsey and J. D. Tucker, Estimation of the target stem cell population size in chronic myeloid leukemogenesis. Radiat. & Env. Biophys. 38, 201-206(1999).

T. Radivoyevitch and D. G. Hoel, Modeling the low-LET dose-response of BCR-ABL formation: Predicting stem cell numbers from A-bomb data. Math. Biosci. 162, 85-101 (1999).

T. Radivoyevitch and D. G. Hoel, Biologically-based risk estimation for radiation-induced chronic myeloid leukemia. Radiat. & Env. Biophys. 39, 153-159 (2000).

T. Radivoyevitch, Time course solutions of the Sax-Markov binary eurejoining/misrejoining model of DNA double-strand breaks. Radiat. & Env. Biophys. 39, 265-273 (2000).

E. O. Voit and T. Radivoyevitch, Biochemical systems analysis of genome-wide expression data. Bioinformatics 16, 1023-1037 (2000).

T. Radivoyevitch, S. Kozubek and R. K. Sachs, Biologically-based risk estimation for radiation-induced CML: Inferences from BCRandABL geometric distributions. Radiat. & Env. Biophys. 40, 1-9 (2001).

T. Radivoyevitch, The death-mutation model of carcinogenesis. Mathematical and Computer Modelling 33, 1219-1226 (2001).

T. Radivoyevitch, R. K. Sachs, Y. E. Nikiforov, M. Nikiforova and M. P. Little, On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer.Radiat. & Env. Biophys. 40, 191-197 (2001).

T. Radivoyevitch, Sphingoid base metabolism in yeast: Mapping gene expression patterns into qualitative metabolite time course predictions. Comparative and Functional Genomics.2, 289-294 (2001).

T. Radivoyevitch, S. Kozubek and R. K. Sachs, The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? Radiat. Res. 157, 106-109 (2002).


Research Support
TR Role
5 R01 GM57245-03 Sachs (PI) 06/01/2000 - 04/30/2001100%
NIH/NIGMS$180,000/yr
Chromatin Geometry and Intrachange Proximity Effects
The major goal of this project was to analyze large-scale chromosome geometry during cell cycle interphase in light of radiobiological data on chromosome aberrations.
TR Role
DE-FG02-99ER62728 Hoel (PI) 11/01/1998 - 2/7/2000 100%
DOE/OBER$75,000/yr
Radiation Leukemogenesis: Applying Basic Science to Epidemiological Estimates of Low Dose Risks and Dose-Rate Effects
The major goal of this project was to develop a biologically based model of radiation-induced chronic myeloid leukemia.