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Catherine M. Stein, PH.D.
Assistant Professor,
Division of Genetic Epidemiology
Genetic susceptibility to infectious diseases,structural equation modeling in genetics.
Office: Wolstein Research Building, Rm. 1316
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- Education
- 2004, Ph.D., Department of Epidemiology and Biostatistics, Case Western Reserve University. Cleveland, OH. Dissertation: Genetic and environmental influences on tuberculosis susceptibility.
Research Interests
- In general, my research focuses on complex genetic disorders. My primary research focus is in the study of genetic and environmental susceptibility to tuberculosis. I am also involved in studies of genetics of HIV and of speech-sound disorder. In addition, I am interested in applying multivariate methods, particularly structural equation models, to the joint analysis of related traits, genes, and clinical covariates.
- Professional Memberships
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American Society of Human Genetics
African Society of Human Genetics
International Genetic Epidemiology Society
American Statistical Association
- Courses Taught
- EPBI 457 - Genetic Linkage Analysis
Recent Publications
Stein CM, Guwatudde D, Nakakeeto M, Peters P, Elston RC, Tiwari HK, Mugerwa R, Whalen CC (2003): Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis 187: 1679-1685.
Jun G, Song Y, Stein CM, Iyengar SK (2003): An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression. BMC Genetics 4(Suppl1): S8.
Stein CM, Song Y, Elston RC, Jun G, Tiwari HK, Iyengar SK (2003): Structural equation model-based genome scan for metabolic syndrome. BMC Genetics 4(Suppl1): S99.
Stein CM, Schick JH, Taylor HG, Shriberg LD, Millard C, Kundtz-Kluge A, Russo K, Minich N, Hansen A, Freebairn LA, Lewis BA, Iyengar SK (2004): Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am J Hum Genet 74: 283-297.
Iyengar SK, Stein CM, Thomas A, Russo K, Erokwu B, Strohl KP (2004): The fa Leptin Receptor Mutation and the Heritability of Respiratory Frequency in a Brown Norway and Zucker Intercross. J Appl Physiol 97: 811-820.
Stein CM, Nshuti L, Chiunda AB, Boom WH, Elston RC, Mugerwa RD, Iyengar SK, Whalen CC (2005): Evidence for a major gene influence on tumor necrosis factor-α expression in tuberculosis: path and segregation analysis. Hum Hered 60: 109-118.
Lewis BA, Freebairn LA, Hansen AJ, Stein CM, Iyengar SK, Taylor HG (2006): Factor Analysis of Early Speech Sound Disorders. J Commun Dis 39: 139-157.
Lewis BA, Freebairn LA, Hansen AJ, Stein CM, Taylor HG, Iyengar SK (2006): The Genetic Bases of Speech Sound Disorders: Evidence from Spoken and Written Language. Journal of Speech, Language, and Hearing Research 49: 1294-1312.
Stein CM, Millard C, Kluge A, Miscimarra LE, Cartier KC, Freebairn LA, Hansen AJ, Shriberg LD, Taylor HG, Lewis BA, Iyengar SK (2006): Speech sound disorder influenced by a locus in 15q14 region. Behav Genet 36: 858-68.
Miscimarra LE, Stein CM, Millard C, Kluge A, Cartier KC, Freebairn FA, Hansen AJ, Shriberg LD, Taylor HG, Lewis BA, Iyengar SK (2007): Further Evidence of Pleiotropy Influencing Speech and Language: Analysis of the DYX8 region. Hum Hered 63: 47-58.
Bochud P-Y, Hersberger M, Taffé P, Bochud M, Stein CM, Rodrigues SD, Calandra T, Francioli P, Telenti A, Speck RF, Aderem A, and the Swiss HIV Cohort Study (2007): Polymorphisms in Toll-like receptor genes influence susceptibility to HIV-1 infection and its clinical course. AIDS 21:441-446.
Stein CM, Zalwango S, Chiunda AB, Millard C, Leontiev DV, Boom WH, Horvath AL, Chervenak K, Elston RC, Mugerwa RD, Whalen CC, Iyengar SK (2007): Linkage and association analysis of candidate genes for TB and TNFα expression: Evidence for association with IFNGR1, IL10, and TNF receptor 1 genes. Hum Genet 121: 663-673.
Nock NL, Larkin EK, Morris NJ, Li Y, Stein CM (2007). Modeling the Complex Gene x Environment Interplay in the Simulated Rheumatoid Arthritis GAW15 Data Using Latent Variable Structural Equation Modeling. BMC Proceedings 1 (Suppl 1): S118.
Larkin EK, Morris NJ, Li Y, Nock NL, Stein CM (2007). Comparison of Affected Sib-Pair Linkage Methods to Identify Gene x Gene Interaction in GAW 15 Simulated Data. BMC Proceedings 1 (Suppl 1): S66.
Beyene J, Tritchler D, Bull SB, Cartier KC, Jonasdottir G, Kraja AT, Li N, Nock NL, Parkhomenko E, Rao JS, Stein CM, Sutradhar R, Waaijenborg S, Wang KS, Wolkow P (2007). Multivariate analysis of complex gene expression and clinical phenotypes with genetic marker data. Genet Epidemiol 31 (Suppl 1): S103-S109.
Bartlett CW, Vieland VJ, Bartlett J, Bell JT, Bhattacharjee S, Clerget-Darpoux F, Bush WS, Edwards TL, Gao G, Halder I, Huang Y, Kotti S, Larkin EK, Li H, Motsinger AA, Mukhodpadhyay N, Namkumg J, Park T, Ritchie MD, Stein CM, Zhou JY (2007). Discussing gene-gene interaction: Warning – Translating equations into English may result in Jabberwocky. Genet Epidemiol 31 (Suppl 1): S61-S67.
- Additional Links
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Multidiscplinary Clinical Research Training Program (K12/KL2)
Tuberculosis Research Unit
Center for AIDS Research
Center for Modern Epidemiology of Infectious Diseases
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