Farren BS Briggs_crop

Farren B. S. Briggs, Ph.D., Sc.M.

Assistant Professor

farren.briggs@case.edu | 216.368.5636 | Wolstein Research Bldg. 1312


Lab Page: http://epbiwww.case.edu/ndge/

Recent Activities: http://epbiwww.case.edu/ndge-lab/


Ph.D., 2010, Epidemiology, University of California, Berkeley
Sc.M., 2005, Biostatistics, Brown University
B.A., 2001, Biology, College of the Holy Cross

Research Interests

Most of my academic training has focused on characterizing the influence of genetic and non-genetic (primarily modifiable exposures) factors on susceptibility and disease manifestation of multiple sclerosis (MS).

My current research spans understanding the etiology and pathology of MS from the micro- to the macro-level. For example, investigating whether a diagnostic signature for MS can be derived from readily available technologies (i.e. metabolomic assays), improving the phenotyping of the disease (which is critical for prognostication and  the development of novel therapeutics), and describing patterns in healthcare utilization.

I also conduct research in other neurological and autoimmune diseases, such as Parksinson’s Disease, stroke, neuromyelitis optica and tranverse myelitis.


I am the course director for PQHS 490 which introduces the fundamentals of Epidemiology. The class is aimed at graduate students, medical students, and advanced undergraduates. It is very much a 0-60mph class, where at the end of the semester students should be comfortable navigating most scientific articles, and able to discuss the study’s validity, the likely role of bias, and the causal implications.

Professional Memberships

American Society of Human Genetics

Society for Epidemiologic Research

Recent Publications

  1. Andersen, SL, Briggs, FBS, Winnike, JH, Natanzon, Y, Maichle, S, Knagge, KJ, Newby, LK, Gregory, SG. Metabolome-based signature of disease pathology in MS. Mult Scler Relat Disord 2019; 31 : 12-21. PubMed PMID:30877925 .
  2. Briggs, FBS, Thompson, NR, Conway, DS. Prognostic factors of disability in relapsing remitting multiple sclerosis. Mult Scler Relat Disord 2019; 30 : 9-16. PubMed PMID:30711764 .
  3. Hill, E, Abboud, H, Briggs, FBS. Prevalence of asthma in multiple sclerosis: A United States population-based study. Mult Scler Relat Disord 2019; 28 : 69-74. PubMed PMID:30557818 .
  4. Briggs, FBS, Yu, JC, Davis, MF, Jiangyang, J, Fu, S, Parrotta, E, Gunzler, DD, Ontaneda, D. Multiple sclerosis risk factors contribute to onset heterogeneity. Mult Scler Relat Disord 2019; 28 : 11-16. PubMed PMID:30529925 .
  5. Saroufim, P, Zweig, SA, Conway, DS, Briggs, FBS. Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis. Mult Scler Relat Disord 2018; 25 : 21-25. PubMed PMID:30014877 .
  6. Mowry, EM, Hedström, AK, Gianfrancesco, MA, Shao, X, Schaefer, CA, Shen, L, Bellesis, KH, Briggs, FBS, Olsson, T, Alfredsson, L, Barcellos, LF. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Mult Scler Relat Disord 2018; 24 : 135-141. PubMed PMID:30005356 .
  7. Mehta, K, Jaiswal, P, Briggs, F, Faubion, WA, Tabibian, JH, Cominelli, F, Dave, M. In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study. Sci Rep 2018; 8 (1): 6825. PubMed PMID:29717163 PubMed Central PMC5931606.
  8. Bush, WS, Crawford, DC, Briggs, F, Freedman, D, Sloan, C. INTEGRATING COMMUNITY-LEVEL DATA RESOURCES FOR PRECISION MEDICINE RESEARCH. Pac Symp Biocomput 2018; 23 : 618-622. PubMed PMID:29218920 .
  9. Galarza-Muñoz, G, Briggs, FBS, Evsyukova, I, Schott-Lerner, G, Kennedy, EM, Nyanhete, T, Wang, L, Bergamaschi, L, Widen, SG, Tomaras, GD, Ko, DC, Bradrick, SS, Barcellos, LF, Gregory, SG, Garcia-Blanco, MA. Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. Cell 2017; 169 (1): 72-84.e13. PubMed PMID:28340352 PubMed Central PMC5456452.
  10. Taqui, A, Cerejo, R, Itrat, A, Briggs, FB, Reimer, AP, Winners, S, Organek, N, Buletko, AB, Sheikhi, L, Cho, SM, Buttrick, M, Donohue, MM, Khawaja, Z, Wisco, D, Frontera, JA, Russman, AN, Hustey, FM, Kralovic, DM, Rasmussen, P, Uchino, K, Hussain, MS, Cleveland Pre-Hospital Acute Stroke Treatment (PHAST) Group. Reduction in time to treatment in prehospital telemedicine evaluation and thrombolysis. Neurology 2017; 88 (14): 1305-1312. PubMed PMID:28275084 .
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