Farren BS Briggs_crop

Farren B.S. Briggs, PhD, ScM

Assistant Professor

farren.briggs@case.edu | 216.368.5636 | Wolstein Research Bldg. 1312



Ph.D., 2010, Epidemiology, University of California, Berkeley
Sc.M., 2005, Biostatistics, Brown University

Research Interests

Integrating genomic, epigenetic, and environmental data to characterize multiple sclerosis, and other autoimmune and neurodegenerative diseases, susceptibility and progression.
Developing strategies for investigating multiplex gene(n)-gene and gene(n)-environment relationships in complex diseases.
Utilizing bioinformatics tools for extracting information from genetic and epigenetic data.
Using genetic and epigenetic profiles to classify patients with complex diseases into homogenous subsets for analysis.
Identifying genetic and environmental factors associated with conversion to MS from clinically isolated syndrome.
Quantifying disability and identifying symptomatology trajectories in MS patients.
Identifying genetic and modifiable risk factors contributing to MS progression.
Characterizing the molecular phenotype of mesenchymal stem cells in MS patients.

Professional Memberships

American Society of Human Genetics
Society for Epidemiologic Research

Recent Publications

  1. Saroufim, P, Zweig, SA, Conway, DS, Briggs, FBS. Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis. Mult Scler Relat Disord 2018; 25 : 21-25. PubMed PMID:30014877 .
  2. Mowry, EM, Hedström, AK, Gianfrancesco, MA, Shao, X, Schaefer, CA, Shen, L, Bellesis, KH, Briggs, FBS, Olsson, T, Alfredsson, L, Barcellos, LF. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Mult Scler Relat Disord 2018; 24 : 135-141. PubMed PMID:30005356 .
  3. Mehta, K, Jaiswal, P, Briggs, F, Faubion, WA, Tabibian, JH, Cominelli, F, Dave, M. In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study. Sci Rep 2018; 8 (1): 6825. PubMed PMID:29717163 PubMed Central PMC5931606.
  4. Bush, WS, Crawford, DC, Briggs, F, Freedman, D, Sloan, C. INTEGRATING COMMUNITY-LEVEL DATA RESOURCES FOR PRECISION MEDICINE RESEARCH. Pac Symp Biocomput 2018; 23 : 618-622. PubMed PMID:29218920 .
  5. Galarza-Muñoz, G, Briggs, FBS, Evsyukova, I, Schott-Lerner, G, Kennedy, EM, Nyanhete, T, Wang, L, Bergamaschi, L, Widen, SG, Tomaras, GD, Ko, DC, Bradrick, SS, Barcellos, LF, Gregory, SG, Garcia-Blanco, MA. Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. Cell 2017; 169 (1): 72-84.e13. PubMed PMID:28340352 PubMed Central PMC5456452.
  6. Taqui, A, Cerejo, R, Itrat, A, Briggs, FB, Reimer, AP, Winners, S, Organek, N, Buletko, AB, Sheikhi, L, Cho, SM, Buttrick, M, Donohue, MM, Khawaja, Z, Wisco, D, Frontera, JA, Russman, AN, Hustey, FM, Kralovic, DM, Rasmussen, P, Uchino, K, Hussain, MS, Cleveland Pre-Hospital Acute Stroke Treatment (PHAST) Group. Reduction in time to treatment in prehospital telemedicine evaluation and thrombolysis. Neurology 2017; 88 (14): 1305-1312. PubMed PMID:28275084 .
  7. Briggs, FB, Gunzler, DD, Ontaneda, D, Marrie, RA. Smokers with MS have greater decrements in quality of life and disability than non-smokers. Mult. Scler. 2017; 23 (13): 1772-1781. PubMed PMID:28059618 PubMed Central PMC5494015.
  8. Gunzler, DD, Morris, N, Perzynski, A, Ontaneda, D, Briggs, F, Miller, D, Bermel, RA. Heterogeneous depression trajectories in multiple sclerosis patients. Mult Scler Relat Disord 2016; 9 : 163-9. PubMed PMID:27645367 PubMed Central PMC5031243.
  9. Hsu, LI, Briggs, F, Shao, X, Metayer, C, Wiemels, JL, Chokkalingam, AP, Barcellos, LF. Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol. Biomarkers Prev. 2016; 25 (5): 815-22. PubMed PMID:26941364 PubMed Central PMC4873450.
  10. George, MF, Holingue, CB, Briggs, FB, Shao, X, Bellesis, KH, Whitmer, RA, Schaefer, C, Benedict, RH, Barcellos, LF. Feasibility study for remote assessment of cognitive function in multiple sclerosis. J Neurol Neuromedicine 2016; 1 (8): 10-18. PubMed PMID:28255581 PubMed Central PMC5330281.
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