Farren BS Briggs_crop

Farren B.S. Briggs, PhD, ScM

Assistant Professor

farren.briggs@case.edu | 216.368.5636 | Wolstein Research Bldg. 1312



Ph.D., 2010, Epidemiology, University of California, Berkeley
Sc.M., 2005, Biostatistics, Brown University

Research Interests

Most of my academic training has focused on characterizing the influence of genetic and non-genetic (primarily modifiable exposures) factors on susceptibility and disease manifestation of multiple sclerosis (MS).

My current research spans understanding the etiology and pathology of MS from the micro- to the macro-level. For example, investigating whether a diagnostic signature for MS can be derived from readily available technologies (i.e. metabolomic assays), improving the phenotyping of the disease (which is critical for prognostication and  the development of novel therapeutics), and describing patterns in healthcare utilization.

I also conduct research in other neurological and autoimmune diseases, such as Parksinson’s Disease, stroke, neuromyelitis optica and tranverse myelitis.


I am the course director for PQHS 490 which introduces the fundamentals of Epidemiology. The class is aimed at graduate students, medical students, and advanced undergraduates. It is very much a 0-60mph class, where at the end of the semester students should be comfortable navigating most scientific articles, and able to discuss the study’s validity, the likely role of bias, and the causal implications.

Professional Memberships

American Society of Human Genetics

Society for Epidemiologic Research

Recent Publications

  1. Saroufim, P, Zweig, SA, Conway, DS, Briggs, FBS. Cardiovascular conditions in persons with multiple sclerosis, neuromyelitis optica and transverse myelitis. Mult Scler Relat Disord 2018; 25 : 21-25. PubMed PMID:30014877 .
  2. Mowry, EM, Hedström, AK, Gianfrancesco, MA, Shao, X, Schaefer, CA, Shen, L, Bellesis, KH, Briggs, FBS, Olsson, T, Alfredsson, L, Barcellos, LF. Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis. Mult Scler Relat Disord 2018; 24 : 135-141. PubMed PMID:30005356 .
  3. Mehta, K, Jaiswal, P, Briggs, F, Faubion, WA, Tabibian, JH, Cominelli, F, Dave, M. In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study. Sci Rep 2018; 8 (1): 6825. PubMed PMID:29717163 PubMed Central PMC5931606.
  4. Bush, WS, Crawford, DC, Briggs, F, Freedman, D, Sloan, C. INTEGRATING COMMUNITY-LEVEL DATA RESOURCES FOR PRECISION MEDICINE RESEARCH. Pac Symp Biocomput 2018; 23 : 618-622. PubMed PMID:29218920 .
  5. Galarza-Muñoz, G, Briggs, FBS, Evsyukova, I, Schott-Lerner, G, Kennedy, EM, Nyanhete, T, Wang, L, Bergamaschi, L, Widen, SG, Tomaras, GD, Ko, DC, Bradrick, SS, Barcellos, LF, Gregory, SG, Garcia-Blanco, MA. Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. Cell 2017; 169 (1): 72-84.e13. PubMed PMID:28340352 PubMed Central PMC5456452.
  6. Taqui, A, Cerejo, R, Itrat, A, Briggs, FB, Reimer, AP, Winners, S, Organek, N, Buletko, AB, Sheikhi, L, Cho, SM, Buttrick, M, Donohue, MM, Khawaja, Z, Wisco, D, Frontera, JA, Russman, AN, Hustey, FM, Kralovic, DM, Rasmussen, P, Uchino, K, Hussain, MS, Cleveland Pre-Hospital Acute Stroke Treatment (PHAST) Group. Reduction in time to treatment in prehospital telemedicine evaluation and thrombolysis. Neurology 2017; 88 (14): 1305-1312. PubMed PMID:28275084 .
  7. Briggs, FB, Gunzler, DD, Ontaneda, D, Marrie, RA. Smokers with MS have greater decrements in quality of life and disability than non-smokers. Mult. Scler. 2017; 23 (13): 1772-1781. PubMed PMID:28059618 PubMed Central PMC5494015.
  8. Gunzler, DD, Morris, N, Perzynski, A, Ontaneda, D, Briggs, F, Miller, D, Bermel, RA. Heterogeneous depression trajectories in multiple sclerosis patients. Mult Scler Relat Disord 2016; 9 : 163-9. PubMed PMID:27645367 PubMed Central PMC5031243.
  9. Hsu, LI, Briggs, F, Shao, X, Metayer, C, Wiemels, JL, Chokkalingam, AP, Barcellos, LF. Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics. Cancer Epidemiol. Biomarkers Prev. 2016; 25 (5): 815-22. PubMed PMID:26941364 PubMed Central PMC4873450.
  10. George, MF, Holingue, CB, Briggs, FB, Shao, X, Bellesis, KH, Whitmer, RA, Schaefer, C, Benedict, RH, Barcellos, LF. Feasibility study for remote assessment of cognitive function in multiple sclerosis. J Neurol Neuromedicine 2016; 1 (8): 10-18. PubMed PMID:28255581 PubMed Central PMC5330281.
Search PubMed