Department of
Epidemiology &
Biostatistics

Genetic Epidemiology

Global Health

Behavior and Prevention

Health Care

Modern Biostatistics

 

Catherine M. Stein, Ph.D.
Associate Professor

 

Office: Wolstein Research Bldg., Rm. 1316
Phone: (216) 368-5631
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

stein
Follow my lab on Twitter!  @SteinGenEpiLab
 
Education
2004, Ph.D., Department of Epidemiology and Biostatistics, Case Western Reserve University. Cleveland, OH.  Dissertation:  Genetic and environmental influences on tuberculosis susceptibility.
Professional Summary
Dr. Stein's research focuses on complex genetic disorders. Her primary research focus is in the study of genetic and environmental susceptibility to tuberculosis. She is the Genetics Working Group Leader of the Tuberculosis Research Unit and co-PI of the Kawempe Community Health Study, a large household contact study of TB.  She also conducts collaborative research in HIV, Rift Valley Fever Virus, and speech-sound disorder.   In addition, she is interested in applying multivariate methods, particularly structural equation models, to the joint analysis of related traits, genes, and clinical covariates.
 
Ongoing Research Projects

Tuberculosis: Examining the influence of epidemiological risk factors, host genetics, microbial genetics, and host immunology on thd development of latent M. tuberculosis infection and active TB disease

Speech-sound disorder: Modeling the relationships of cognitive domains underlying speech-sound disorder, how these predict later outcomes in reading deficiency, and mapping genes underlying both these clinical traits and endophenotypes

Rift Valley Fever Virus: Association studies to examine genes related to RVFV susceptibility, immune response underlying RVFV, and RVFV-associated retinitis

Structural Equation Modeling in Family Data: We have released 'strum' software, an R package that implements a generalized framework to conduct SEM analyses in family data based on methodology developed by Dr. Nathan Morris 

 
Professional Memberships
American Society of Human Genetics
African Society of Human Genetics
International Genetic Epidemiology Society
American Statistical Association

Courses Taught
EPBI/MPHP/INTH 494 - Epidemiology of Infectious Disease (TB and HIV modules)
EPBI 445 - Research Ethics in Population Health Sciences
EPBI 460 - Public Health Genomics module
Selected Recent Publications
Stein CM, Zalwango S, Malone LL, Won S, Mayanja-Kizza H, Mugerwa RD, Leontiev DV, Thompson CL, Cartier KC, Elston RC, Iyengar SK, Boom WH, Whalen CC (2008). Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS ONE 3: e4094

Stein CM, Elston RC (2009). Finding genes underlying human disease. Clin Genet 75: 101-106

Stein CM (2011). Genetic epidemiology of tuberculosis susceptibility: Impact of study design.  PLoS Pathog 7 (1): e1001189. PMCID: PMC3024264

Morris NJ, Elston RC, Stein CM (2010). A Framework for Structural Equation Models (SEM) in General Pedigrees. Hum Hered 70: 278–286.  PMCID: PMC3164176

Lewis BA, Avrich AA, Freebairn LA, Hansen AJ, Sucheston LE, Kuo I, Taylor HG, Iyengar SK, Stein CM (2011). Outcomes of Children with Speech Sound Disorders: Impact of Endophenotypes. Journal of Speech, Language, and Hearing Research 54: 1628-1643  PMCID: PMC3404457

Baker AR, Qiu F, Randhawa AK, Horne DJ, Adams MD, Shey M, Barnholtz-Sloan J, Mayanja-Kizza H, Kaplan G, Hanekom WA, Boom WH, Hawn TR, Stein CM (2012). Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data. PLoS One 7(10):e47597. PMCID: PMC3480404

Tao L, Zalwango S, Chervenak K, Thiel B, Malone LL, Qiu F, Mayanja-Kizza H, Boom WH, Stein CM. Genetic and shared environmental influences on interferon-γ production in response to Mycobacterium tuberculosis antigens in a Ugandan population. Am J Trop Med Hyg 89:169-73. PMCID: PMC3748477

Jaganath D, Zalwango S, Okware B, Nsereko M, Kisingo H, Malone L, Lancioni C, Okwera A, Joloba M, Mayanja-Kizza H, Boom WH, Stein C, Mupere E (2013). Contract Investigation for Active Tuberculosis among Child Contacts in Uganda. Clin Infect Dis 57: 1685-92.  PMCID: PMC3840405

Johnson DF, Malone LL, Zalwango S, Mukisa Oketcho J, Chervenak KA, Thiel B, Mayanja-Kizza H, Stein CM, Boom WH, Lancioni CL (2014). TST Reversion Reflects Diversity of Immune Response to Primary Mycobacterium tuberculosis Infection. PloS ONE 9(5): e96613. PMCID: PMC4010490

Ma N, Zalwango S, Malone LL, Nsereko M, Wampande EM, Thiel BA, Okwera B, Igo Jr RP, Joloba ML, Mupere E, Mayanja-Kizza H, Boom WH, Stein CM (2014). Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda. BMC Infect Dis 14:352. PMCID: PMC4091673

Stein CM, Truitt B, Deng F, Avrich Ciesla A, Qiu F, Joseph P, Raghavendra R, Fondran J, Igo RP, Tag J, Freebairn L, Taylor HG, Lewis BA, Iyengar SK. Association between AVPR1A, DRD2, and ASPM and Endophenotypes of Communication Disorders. In press, Psych Genet

 

Additional Links

Multidiscplinary Clinical Research Training Program (K12/KL2)
Tuberculosis Research Unit
Center for AIDS Research

Graduates

Nathan Morris, Ph.D.  Present position: Senior Instructor, Department of Epidemiology and Biostatistics, Case Western Reserve University

Allison Baker, M.S.  Present position: Clinical Analytics Analyst, Hospital Corporation of America

Allison Avrich Ciesla, M.S.  Present position: Independent contractor / data analyst, Cleveland Family SSD study, Case Western Reserve University

Denise Johnson, MPH, M.S. Present position: Director of Operations & Data Management, Tuberculosis Research Unit, Case Western Reserve University

 

Last Updated (Thursday, 17 July 2014 20:55)

 
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