Catherine M. Stein, Ph.D. Associate Professor   Office: Wolstein Research Bldg., Rm. 1316 Phone: (216) 368-5631 E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Education

2004, Ph.D., Department of Epidemiology and Biostatistics, Case Western Reserve University. Cleveland, OH.  Dissertation:  Genetic and environmental influences on tuberculosis susceptibility.

Professional Summary

Dr. Stein's research focuses on complex genetic disorders. Her primary research focus is in the study of genetic and environmental susceptibility to tuberculosis. She is the Genetics Working Group Leader of the Tuberculosis Research Unit and co-PI of the Kawempe Community Health Study, a large household contact study of TB.  She also conducts collaborative research in HIV, Rift Valley Fever Virus, and speech-sound disorder.   In addition, she is interested in applying multivariate methods, particularly structural equation models, to the joint analysis of related traits, genes, and clinical covariates.

 

Ongoing Research Projects

Tuberculosis: Examining the influence of epidemiological risk factors, host genetics, microbial genetics, and host immunology on thd development of latent M. tuberculosis infection and active TB disease

Speech-sound disorder: Modeling the relationships of cognitive domains underlying speech-sound disorder, how these predict later outcomes in reading deficiency, and mapping genes underlying both these clinical traits and endophenotypes

Rift Valley Fever Virus: Association studies to examine genes related to RVFV susceptibility, immune response underlying RVFV, and RVFV-associated retinitis

Structural Equation Modeling in Family Data: We are currently developing software to implement a generalized framework to conduct SEM analyses in family data based on methodology developed by Dr. Nathan Morris 

 

Professional Memberships

American Society of Human Genetics
African Society of Human Genetics
International Genetic Epidemiology Society
American Statistical Association

Courses Taught

EPBI/MPHP/INTH 494 - Epidemiology of Infectious Disease (TB and HIV modules)

EPBI 445 - Research Ethics in Population Health Sciences

Selected Recent Publications

Stein CM, Guwatudde D, Nakakeeto M, Peters P, Elston RC, Tiwari HK, Mugerwa R, Whalen CC (2003): Heritability analysis of cytokines as intermediate phenotypes of tuberculosis. J Infect Dis 187: 1679-1685.

Stein CM, Schick JH, Taylor HG, Shriberg LD, Millard C, Kundtz-Kluge A, Russo K, Minich N, Hansen A, Freebairn LA, Lewis BA, Iyengar SK (2004): Pleiotropic effects of a chromosome 3 locus on speech-sound disorder and reading. Am J Hum Genet 74: 283-297.

Stein CM, Nshuti L, Chiunda AB, Boom WH, Elston RC, Mugerwa RD, Iyengar SK, Whalen CC (2005): Evidence for a major gene influence on tumor necrosis factor-α expression in tuberculosis: path and segregation analysis. Hum Hered 60: 109-118.

Lewis BA, Freebairn LA, Hansen AJ, Stein CM, Taylor HG, Iyengar SK (2006): The Genetic Bases of Speech Sound Disorders: Evidence from Spoken and Written Language. Journal of Speech, Language, and Hearing Research 49: 1294-1312.

Stein CM, Zalwango S, Chiunda AB, Millard C, Leontiev DV, Boom WH, Horvath AL, Chervenak K, Elston RC, Mugerwa RD, Whalen CC, Iyengar SK (2007): Linkage and association analysis of candidate genes for TB and TNFα expression: Evidence for association with IFNGR1, IL10, and TNF receptor 1 genes. Hum Genet 121: 663-673.

Nock NL, Larkin EK, Morris NJ, Li Y, Stein CM (2007). Modeling the Complex Gene x Environment Interplay in the Simulated Rheumatoid Arthritis GAW15 Data Using Latent Variable Structural Equation Modeling. BMC Proceedings 1 (Suppl 1): S118.

Lewinsohn DA, Zalwango S, Stein CM, Mayanja-Kizza H, Okwera A, Boom WH, Mugerwa R, Whalen CC (2008). Whole blood interferon-gamma responses to Mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda. PLoS ONE 3: e3407

Stein CM, Zalwango S, Malone LL, Won S, Mayanja-Kizza H, Mugerwa RD, Leontiev DV, Thompson CL, Cartier KC, Elston RC, Iyengar SK, Boom WH, Whalen CC (2008). Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS ONE 3: e4094

Stein CM, Elston RC (2009). Finding genes underlying human disease. Clin Genet 75: 101-106

Morris NJ, Gray-McGuire C, Stein CM (2009). Mendelian Randomization in Family Data. BMC Proceedings 3 Suppl 7: S45

Nock NL, Wang X, Thompson CL, Song Y, Baechle D, Raska P, Stein CM, Gray-McGuire C (2009). Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods. BMC Proceedings 3 Suppl 7: S50

Morris NJ, Elston RC, Stein CM (2009). Calculating asymptotic significance levels of the constrained likelihood ratio test with application to multivariate genetic linkage analysis. Statistical Applications in Genetics and Molecular Biology 8 (1) Article 39.

Stein CM, Baker AR (2011). Tuberculosis as a complex trait: Impact of genetic epidemiological study design. Mamm Genome 22: 91-99.

Stein CM (2011). Genetic epidemiology of tuberculosis susceptibility: Impact of study design.  PLoS Pathog 7 (1): e1001189. 

Morris NJ, Elston RC, Stein CM (2010). A Framework for Structural Equation Models (SEM) in General Pedigrees. Hum Hered 70: 278–286.

Lewis BA, Avrich AA, Freebairn LA, Hansen AJ, Sucheston LE, Kuo I, Taylor HG, Iyengar SK, Stein CM+ (2011). Outcomes of Children with Speech Sound Disorders: Impact of Endophenotypes. Journal of Speech, Language, and Hearing Research 54: 1628-1643

Baker AR, Zalwango S, Malone LL, Igo Jr RP, Qiu F, Nsereko M, Adams MD, Supelak P, Mayanja-Kizza H, Boom WH, Stein CM (2011). Genetic Susceptibility to Tuberculosis Associated with CTSZ Haplotype in Ugandan Household Contact Study. Hum Immunol 72: 426-430.

Mahan CS, Zalwango S, Thiel BA, Malone L, Chervenak KA, Baseke J, Dobbs D, Stein CM, Mayanja H, Joloba M, Whalen CC, Boom WH (2012). Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, Uganda. In press, Am J Trop Med Hyg

Additional Links

Multidiscplinary Clinical Research Training Program (K12/KL2)
Tuberculosis Research Unit
Center for AIDS Research

Graduates

Nathan Morris, Ph.D.  Present position: Instructor, Department of Epidemiology and Biostatistics, Case Western Reserve University

Allison Baker, M.S.  Present position: Research assistant, Center for Human Genetics Research, Vanderbilt University Medical Center