Department of
Epidemiology &
Biostatistics

Genetic Epidemiology

Global Health

Behavior and Prevention

Health Care

Modern Biostatistics

 

 

Tomas Radivoyevitch
Assistant Professor

  

Office: School of Medicine, BRB G-19
Phone: (216) 368-1965
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Website: epbi-radivot.case.edu

radivoy

Education
Ph.D. 1996, Medical University of South Carolina: Environmental Risk Assessment
M.S. 1992, Case Western Reserve University: Chemistry
M.S. 1987, Case Western Reserve University: Systems Engineering
B.S. 1986, Case Western Reserve University: Electrical Engineering
Research Interests
Theoretical radiation leukemogensis. Automated enzyme model generation and selection methods. Deoxyribonucleotide metabolism.
Positions
1986-1987        Teaching Assistant, Systems Engineering, Case, Cleveland, OH
1988-1988        Programmer, Max Planck Institute, Göttingen, Germany
1989-1991        Applications Engineer, Bailey Controls Company, Wickliffe, OH
1991-1992        Research Assistant, Chemistry, Case, Cleveland, OH
1992-1993        Teaching Assistant, Biochemistry, Ohio State University, Columbus, OH
1993-1996        Graduate Student, Biometry, MUSC, Charleston, SC
1997-1998        Postdoctoral Fellow, Biometry, MUSC, Charleston, SC
1998-2000        Research Instructor, Biometry, MUSC, Charleston, SC
2000-2001        Visiting Research Mathematician, University of California, Berkeley, CA
2001-present    Assistant Professor, Epidemiology and Biostatistics, Case, Cleveland, OH
Peer-Reviewed Publications
Piston, D., Marriot, G., Radivoyevitch, T. , Clegg, R. M., Jovin, T. M. and Gratton, E., Wide-band acousto-optic light modulator for frequency domain fluorometry and phosphorimetry. Rev Sci Instrum 60, 2596-2600 (1989).

Klippenstein, S. J. and Radivoyevitch, T. , A theoretical study of the dissociation of NO2. J Chem Phys 99, 3644-3653 (1993).

Cedervall, B. and Radivoyevitch, T. , Methods for analysis of DNA fragment distributions on pulsed field gel electrophoretic gels. Electrophoresis 17, 1080-1086 (1996).

Radivoyevitch, T. and Cedervall, B., Mathematical analysis of DNA fragment distribution models used with pulsed-field gel electrophoresis for DNA double-strand break calculations. Electrophoresis 17, 1087-1093 (1996).

Radivoyevitch, T., D. G. Hoel, A. M. Chen and R. K. Sachs, Misrejoining of double-strand breaks after X-irradiation: Relating moderate to very high doses by a Markov model. Radiation Research 149, 59-67 (1998).

Radivoyevitch, T., D. G. Hoel, P. Hahnfeldt, B. Rydberg and R. K. Sachs, Recent data obtained by pulsed-field gel electrophoresis suggest two types of double-strand breaks. Radiation Research 149, 52-58 (1998).

Radivoyevitch, T., D. G. Hoel, P. Hahnfeldt and R. K. Sachs, Size distributions of misrejoining DNA fragments in irradiated cells. Mathematical Biosciences 149, 107-136 (1998).

Radivoyevitch, T., M. J. Ramsey and J. D. Tucker, Estimation of the target stem cell population size in chronic myeloid leukemogenesis. Radiat. & Env. Biophys. 38, 201-206(1999).

Radivoyevitch, T. and D. G. Hoel, Modeling the low-LET dose-response of BCR-ABL formation: Predicting stem cell numbers from A-bomb data. Mathematical Biosciences 162, 85-101 (1999).

Radivoyevitch, T. and D. G. Hoel, Biologically-based risk estimation for radiation-induced chronic myeloid leukemia. Radiation & Env. Biophys. 39, 153-159 (2000).

Radivoyevitch, T., Time course solutions of the Sax-Markov binary eurejoining/misrejoining model of DNA double-strand breaks. Radiat. & Env. Biophys. 39, 265-273 (2000).

E. O. Voit and Radivoyevitch, T., Biochemical systems analysis of genome-wide expression data. Bioinformatics 16, 1023-1037 (2000).

Radivoyevitch, T., S. Kozubek and R. K. Sachs, Biologically-based risk estimation for radiation-induced CML: Inferences from BCR and ABL geometric distributions. Radiat. & Env. Biophys. 40, 1-9 (2001).

Radivoyevitch, T., The death-mutation model of carcinogenesis. Mathematical and Computer Modelling 33, 1219-1226 (2001).

Radivoyevitch, T., R. K. Sachs, Y. E. Nikiforov, M. Nikiforova and M. P. Little, On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer. Radiat. & Env. Biophys. 40, 191-197 (2001).

Radivoyevitch, T., Sphingoid base metabolism in yeast: Mapping gene expression patterns into qualitative metabolite time course predictions. Comparative and Functional Genomics 2, 289-294 (2001).

Radivoyevitch, T., S. Kozubek and R. K. Sachs, The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped? Radiation Research 157, 106-109 (2002).

P. Taverna, H. S. Hwang, J. E. Schupp, Radivoyevitch, T., N. N. Session, G. Reddy, D. A. Zarling and T. J. Kinsella, Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization. Cancer Research 63, 838-846 (2003).

Radivoyevitch, T., , P. Taverna, J. E. Schupp, and T. J. Kinsella, The Linear-Quadratic Log-Survival Radiation Dose Response Model: Confidence Ellipses, Drug-Drug Interactions and Brachytherapeutic Gains. Medical Hypotheses and Research 1, 23-28 (2004).

Radivoyevitch, T., A two-way interface between limited Systems Biology Markup Language and R. BMC Bioinformatics 5, 190 (2004).

Radivoyevitch, T., Folate system correlations in DNA microarray data. BMC Cancer 5, 95 (2005).

Radivoyevitch, T., O. B. Kashlan and B. S. Cooperman, Rational Polynomial Representation of Ribonucleotide Reductase Activity. BMC Biochemistry 6, 8 (2005).   PMC1142302

A. Dowlati, K. Robertson, Radivoyevitch, T., J. Waas, N. P. Ziats, P. Hartman, F. W. Abdul-Karim, J. K. Wasman, J. Jesberger, J. Lewin. K. McCrae, P.Ivy and S.C. Remick, Novel Phase I Dose De-escalation Design Trial to Determine the Biological Modulatory Dose of the Antiangiogenic Agent SU5416. Clinical Cancer Research 11, 7938-7944 (2005).

Y. Seo, T. Yan, J. E. Schupp, Radivoyevitch, T. and T. J. Kinsella, Schedule-dependent drug effects of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as an in vivo radiosensitizer in U251 human glioblastoma xenografts. Clinical Cancer Research 11, 7499-7507 (2005).

Y. Seo, T. Yan, J. E. Schupp, K. Yamane, Radivoyevitch, T. and T. J. Kinsella, The Interaction between Two Radiosensitizers: 5-Iododeoxyuridine and Caffeine. Cancer Research 66, 490-498 (2006).

Radivoyevitch, T., K. A. Loparo, R. C. Jackson and W.D.Sedwick, On systems and control approaches to therapeutic gain. BMC Cancer 6, 104 (2006).PMC1484487

Overmoyer, B., Fu, P., Hoppel, C., Radivoyevitch, T., Shenk, R., Persons, M., Silverman, P., Robertson, K., Ziats, N. P., Wasman, J. K., Abdul-Karim, F. W., Jesberger, J. A., Duerk, J., Hartman, P., Hanks, S., Lewin, J., Dowlati, A., McCrae, K., Ivy, P. & Remick, S. C. Inflammatory breast cancer as a model disease to study tumor angiogenesis: results of a phase IB trial of combination SU5416 and doxorubicin. Clin Cancer Res 13, 5862-8 (2007).

Radivoyevitch, T., Equilibrium model selection: dTTP induced R1 dimerization. BMC Systems Biology 2, 15 (2008). PMC2268910

Azizi, F., Wan, Q., Radivoyevitch, T., Dealwis, C. & Mastrangelo C.H.  A Combinatorial Multicomponent Plug Mixer for Systems Chemistry. Micro Total Anal Syst., 1904-1906 (2008). PMC2857516

Feng, I.J.& Radivoyevitch, T. SNP-SNP interactions between the dNTP supply and mismatch DNA repair systems in breast cancer. Ohio Collaborative Conference on Bioinformatics 2009 (OCCBIO ’09).

Radivoyevitch, T.,  Mass action models versus the Hill model: An analysis of tetrameric human thymidine kinase 1 positive cooperativity, Biology Direct 4, 49 (2009). PMC2799445

Radivoyevitch, T., Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: An analysis of ATP-induced ribonucleotide reductase R1 hexamerization data, Biology Direct 4, 50 (2009). PMC2799446

Radivoyevitch, T.,  How to use the computing environment R to analyze  ATP-induced ribonucleotide reductase R1 hexamerization data. Nucleosides, Nucleotides and Nucleic Acids 29, 427-432  (2010).

Kunos, C. A., Radivoyevitch, T., Pink, J., Chiu, S. M., Stefan, T. , Jacobberger, J. & Kinsella, T. J.   Ribonucleotide Reductase Inhibition Enhances Chemoradiosensitivity of Human Cervical Cancers. Radiat Res. 174 (5):574-81 (2010)

Kunos C.A., Colussi V.C., Pink J., Radivoyevitch T., Oleinick N.L. Radiosensitization of Human Cervical Cancer Cells by Inhibiting Ribonucleotide Reductase: Enhanced Radiation Response at Low-Dose Rates. Int J Radiat Oncol Biol Phys. (2011).

Radivoyevitch, T., Munch-Petersen, B., Wang, L. and Eriksson, S. A mathematical model of human thymidine kinase 2 activity, Nucleosides, Nucleotides and Nucleic Acids, 30, 203-209 (2011).

Manilich EA, OzsoyoGlu ZM, Trubachev V, Radivoyevitch T. Classification of Large Microarray Datasets Using Fast Random Forest Construction. J Bioinform Comput Biol, 9(2), 251-267 (2011).

Kunos, C. A., Ferris, G., Pyatka, N., Pink, J. and Radivoyevitch, T., Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers. Radiation Research 176, 425-433 (2011). PMC3191339

Manilich, E. A., Kiran, R. P., Radivoyevitch, T., Lavery, I., Fazio, V. W. and Remzi, F. H., A novel data-driven prognostic model for staging of colorectal cancer. J Am Coll Surg 213, 579-588, 588 e571-572 (2011).

Ng, K. P., Ebrahem, Q., Negrotto, S., Mahfouz, R. Z., Link, K. A., Hu, Z., Gu, X., Advani, A., Kalaycio, M., Sobecks, R., Sekeres, M., Copelan, E., Radivoyevitch, T., Maciejewski, J., Mulloy, J. C. and Saunthararajah, Y., p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia. Leukemia 25, 1739-1750 (2011).

Kunos, C., Radivoyevitch, T., Abdul-Karim, F. W. and Faulhaber, P., 18F-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography Standard Uptake Value Ratio as an Indicator of Cervical Cancer Chemoradiation Therapeutic Response. International journal of gynecological cancer 21, 1117-1123 (2011).

Kunos, C. A., Radivoyevitch, T., Ingalls, S. T. and Hoppel, C. L., Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia. Future oncology 8, 145-150 (2012).

Saunthararajah, Y., Triozzi, P., Rini, B., Singh, A., Radivoyevitch, T., Sekeres, M., Advani, A., Tiu, R., Reu, F., Kalaycio, M., Copelan, E., Hsi, E., Lichtin, A. and Bolwell, B., p53-Independent, Normal Stem Cell Sparing Epigenetic Differentiation Therapy for Myeloid and Other Malignancies. Seminars in oncology 39, 97-108 (2012).

Radivoyevitch, T. and Kunos, C. A., On model ensemble analyses of nonmonotonic data. Nucleosides, nucleotides & nucleic acids 31, 147-156 (2012).

Radivoyevitch, T. , Hlatky, L., Landaw, J. and Sachs, R. K., Quantitative modeling of chronic myeloid leukemia: insights from radiobiology. Blood 119, 4363-4371 (2012).

Kunos, C., Radivoyevitch, T. , Abdul-Karim, F. W., Fanning, J., Abulafia, O., Bonebrake, A. J. and Usha, L., Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group study. Journal of translational medicine 10, 79 (2012).

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