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Rob Igo, Ph.D. Office: Wolstein Research Bldg. Rm. 1302 |
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- Education
- B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005
- Research Interests
- I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, abdominal aortic aneurysm, age-related macular degeneration and phenotype severity in cystic fibrosis. I am involved in the Human Genetic Analysis Resourse (H.G.A.R.), a collaborative project that develops statistical methods to analyze genetic data with an eye toward localizing genetic variants that cause disease, and that implements these approaches in the Statistical Analysis for Genetic Epidemiology (S.A.G.E.) software package.
- Professional Memberships
- American Society of Human Genetics
International Genetic Epidemiology Society
- Courses Taught
- EPBI 452: Statistical Methods for Genetic Epidemiology
- Recent Publications
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Igo RP Jr. and Schnell A (2011). Comparison of requirements and capabilities of major multipurpose software packages. In Statistical Human Genetics (Elston RC, Satagopan JM, Sun S, eds.), Humana Press, New York, in press.
Schnell AH, Sun X, Igo RP Jr, Elston RC (2011). Some capabilities for model-based and model-free linkage analysis using the program package S.A.G.E. (Statistical Analysis for Genetic Epidemiology). Hum Hered, in press.
Sivakumaran TA*, Igo RP Jr*, Kidd JM, Itsara A, Kopplin LJ et al. (2011). A 32-kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. PLoS One 6, e25598.
*these authors contributed equally to this work
Louttit MD, Kopplin LJ, Igo RP Jr, Fondran JR, Tagliaferri A et al. (2011). A multi-center study to map genes for Fuchs' endothelial corneal dystrophy: baseline characteristics and heritability. Cornea, in press.
Igo RP Jr, Iyengar SK, Nicholas SB, Goddard KA, Langefeld CD et al. (2011). Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND Study. Am J Nephrol 33, 381-389.
Baker AR, Zalwango S, Malone LL, Igo RP Jr, Qiu F et al. (2011). Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. Hum Immunol 72, 426-430.
Lillvis JH, Kyo Y, Tromp G, Lenk GM, Li M, Lu Q, Igo RP Jr et al. (2011). Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19. BMC Med Genet 12, 14.
Kopplin LJ, Igo RP Jr, Wang Y, Sivakumaran TA, Hagstrom SA et al. (2010). Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun 11, 609-621.
Wijsman EM, Rothstein JH, Igo RP Jr, Brunzell JD, Motulsky AG and Jarvik GP (2010). Linkage and association analysis identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families. Hum Genet 127, 705-719.
Igo RP Jr, Luo Y and Li S (2010). Markov chain Monte Carlo linkage analysis: methods and software packages. In Handbook on Analyzing Human Genetic Data: Computational Approaches and Software, Springer-Verlag, New York.
Malhotra A, Igo RP Jr,, Thameem F, Kao WHL, Abboud HE, Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI et al. (2009). Genome-wide linnkage scans for type 2 diabetes mellitus in four ethnically diverse populations: significant evidence for linkage on chromosome 4q in African Americans. Diabetes Metab 25, 740-747.
Sinha R, Igo RP Jr, Saini SK, Elston RC and Luo Y (2009). Bayesian intervals for linkage locations. Genet Epidemiol 33, 604-616.
Igo RP Jr, Li J and Goddard KAB (2009). Association mapping by generalized linear regression with density-based haplotype clustering. Genet Epidemiol, 33, 16-26.
Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW, Duggirala R, Elston RC, Guo X, Hanson RL, Igo RP Jr et al. (2008). Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci 49, 3839-3845.
Brkanac Z, Chapman NH, Igo RP Jr, Matsushita MM, Nielsen K, Berninger VW, Wijsman EM and Raskind WH (2008). Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple loci. Behav Genet 38, 462-475.
Igo RP Jr and Wijsman EM (2008). Empirical significance values for linkage analysis: trait simulation using posterior model distributions from MCMC oligogenic segregation analysis. Genet Epidemiol 32, 119-131.
Igo RP Jr, Londono D, Miller K, Parrado AR, Quade SRE, Sihna M, Kim S, Won S, Li J and Goddard KAB (2007). Density-based clustering in haplotype analysis for association mapping. BMC Proc 1 (Suppl 1), S27.
Bickeböller, H., Goddard, K. A. B., Igo, R. P., Jr., Kraft, P., Lozano, J. P., and Pankratz, N. (2007). Issues in association mapping with high-density SNP data and diverse family structures. Genet Epidemiol 31 (Suppl 1), S22-S33.
- Additional Links
- H.G.A.R.
Last Updated (Monday, 21 November 2011 19:46)
