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Rob Igo, Ph.D.
Assistant Professor


Office: Wolstein Research Bldg. Rm. 1302
Phone: (216) 368-4562
E-mail: rpi (at) case (dot) edu

B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005
Research Interests
I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, age-related macular degeneration and susceptibility to tuberculosis.
Professional Memberships
American Society of Human Genetics
International Genetic Epidemiology Society
Courses Taught
EPBI 452: Statistical Methods for Genetic Epidemiology
EPBI 502: Genetic Epidemiology Seminar
Recent Publications

Ma N, Zalwango S, Malone LL, Nsereko M, Wampande EM, Thiel BA, Okware B, Igo RP, Jr., Joloba ML, Mupere E, Mayanja-Kizza H, Boom WH, Stein CM, Tuberculosis Research Unit (2014). Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda. BMC Infect. Dis. 14, 352.

Li YJ, Minear MA, Qin X, Rimmler J, Hauser MA, Allingham RR, Igo RP, Jr., Lass JH, Iyengar SK, Klintworth GK, Afshari NA, Gregory S (2014). Mitochondrial polymorphism A10398G and haplogroup I are associated with Fuchs endothelial corneal dystrophy. Invest. Ophthalmol. Vis. Sci. doi:  10.1167/iovs.13-13517.

Ratnapriya R, Zhan X, Fariss RN, Branham K, Zipprer D, Chakarova CF, Sergeev YV, Campos MM, Othman M, Friedman JS, Maminishkis A, Waseem NH, Brooks M, Rajasimha HK, Edwards AO, Lotery A, Klein BEK, Truitt B, Li B, Schaumberg DA, Morgan DJ, Morrison MA, Souied E, Tsironi EE, Grassmann F, Fishman GA, Silvestri G, Scholl HPN, Kim IK, Ramke J, Tuo J, Merriam JE, Merriam JC, Park KH, Olson LM, Farrer LA, Johnson MP, Peachey NS, Lathrop GM, Baron RV, Igo RP, Jr., Klein R, Hagstrom SA, Kamatani Y, Martin TM, Jiang Y, Conley Y, Sahel J-A, Zack DJ, Chan C-C, Pericak-Vance MA, Jacobson SG, Gorin MB, Klein ML, Allikmets R, Iyengar SK, Weber BHF, Haines JL, Léveillard T, DeAngelis MM, Stambolian D, Weeks DE, Bhattacharya SS, Chew EY, Heckenlively JR, Abecasis GR, Swaroop A (2014). Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration. Hum. Mol. Genet., in press.

Stein CM, Truitt B, Deng F, Ciesla AA, Qiu F, Joseph P, Raghavendra R, Fondran J, Igo RP, Jr., Tag J, Freebairn L, Taylor HG, Lewis BA, Iyengar SK (2014). Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders. Psychiatr. Genet. doi: 10.1097/YPG.0000000000000045.

Cheruvu VK, Igo RP, Jr., Jurevie RJ, Serre D, Zimmerman PA, Rodriguez B, Mehlorta RK (2014). African ancestry influences CCR5 –2459G>A genotype-associated virologic success of highly active antiretroviral therapy. J Acquir. Immune Defic. Syndr. 66, 102-107.

Meyers KJ, Mares JA, Igo RP, Jr., Truitt B, Liu Z, Millen AE, Klein M, Johnson EJ, Engelman CD, Karki CK, Blodi B, Gehrs K, Tinker L, Wallace R, Robinson J, Leblanc ES, Sarto G, Bernstein PS, SanGiovanni JP, Iyengar SK (2014). Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Invest. Ophthalmol. Vis. Sci. 55, 587-599.

Thameem F, Igo RP, Jr., Freedman BI, Langefeld C, Hanson RL, Schelling JR, Elston RC, Duggirala R, Nicholas SB, Goddard KA, Divers J, Guo X, Ipp E, Kimmel PL, Meoni LA, Shah VO, Smith MW, Winkler CA, Zager PG, Knowler WC, Nelson RG, Pahl MV, Parekh RS, Kao WH, Rasooly RS, Adler SG, Abboud HE, Iyengar SK, Sedor JR, Family Investigation of Nephropathy and Diabetes Research Group (2013). A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND). PLoS ONE 8, e81888.

Cheng C-Y, Schache M, Ikram MA, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJM, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PTVM, Vingerling JR, Zhou X, Chen P, Li R, Tay W-T, Zheng Y, Chew M, Consortium for Refractive Error and Myopia (CREAM), Burdon KP, Craig JE, Iyengar SK, Igo RP, Jr., et al. (2013). Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. Am J Hum Genet 93, 264-277.

Zhang X, Igo RP Jr., Fondran JR, Mootha VV, Oliva M, Hammersmith K, Sugar A, Lass JH, Iyengar SK (2013). Association of smoking and other risk factors with Fuchs’ endothelial corneal dystrophy severity and corneal thickness. Invest Ophthalmol Vis Sci 54, 5829-5835.

Fritsche LG, Chen W, Schu M, Yaspan BL, Yu Y, Thorleifsson G, Zack DJ, Arakawa S, Cipriani V, Ripke S, Igo RP Jr. et al. (2013). Seven new loci associated with age-related macular degeneration: the AMDGene Consortium. Nat Genet 45, 433-439.

Meyers KJ, Johnson EJ, Bernstein PS, Iyengar SK, Engelman CD, Karki CK, Liu Z, Igo RP Jr., Truitt B, Klein ML, Snodderly DM, Blodi BA, Gehrs KM, Sarto GE, Wallace RB, Robinson J, Leblanc ES, Hageman G, Tinker L and Mares JA (2013). Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study. Invest Ophthalmol Vis Sci 54, 2333-2345.

Verhoeven VJM, Hysi PG, Wojciechowski R, ..., Igo RP Jr., ..., Hammond CJ (2013). Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet 45, 314-318. (74th of 112 authors.)

Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo RP Jr., Truii B, Robinson J, Sarto GE, Wallace R, Blodi BA, Klein ML, Tinker L, Leblanc ES, Jackson RD, Song Y, Manson JE, Mares JA, Millen AE (2012). Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations. J Nutr 143, 17-26.

Igo RP Jr., Kopplin LJ, Joseph P, Truitt B, Fondran J, Bardenstein D, Aldave AJ, Croasdale CR, Price MO, Rosenwasser M, Lass JH, Iyengar SK (2012). Differing roles for TCF4 and COL8A2 in central corneal thickness and Fuchs endothelial corneal dystrophy. PLoS ONE 7, e46742.

Igo RP Jr. and Schnell A (2012).  Comparison of requirements and capabilities of major multipurpose software packages. Methods Mol Biol 850, 539-558.

Schnell AH, Sun X, Igo RP Jr, Elston RC (2011).  Some capabilities for model-based and model-free linkage analysis using the program package S.A.G.E. (Statistical Analysis for Genetic Epidemiology).  Hum Hered 72, 237-246.

Sivakumaran TA*, Igo RP Jr*, Kidd JM, Itsara A, Kopplin LJ et al. (2011).  A 32-kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.  PLoS One 6, e25598.

*these authors contributed equally to this work

Louttit MD, Kopplin LJ, Igo RP Jr, Fondran JR, Tagliaferri A et al. (2011).  A multi-center study to map genes for Fuchs' endothelial corneal dystrophy:  baseline characteristics and heritability.  Cornea 31, 26-35.

Igo RP Jr, Iyengar SK, Nicholas SB, Goddard KA, Langefeld CD et al. (2011).  Genomewide linkage scan for diabetic renal failure and albuminuria:  the FIND Study.  Am J Nephrol 33, 381-389.

Baker AR, Zalwango S, Malone LL, Igo RP Jr, Qiu F et al. (2011).  Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study.  Hum Immunol 72, 426-430.

Lillvis JH, Kyo Y, Tromp G, Lenk GM, Li M, Lu Q, Igo RP Jr et al. (2011).  Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19.  BMC Med Genet 12, 14.

Kopplin LJ, Igo RP Jr, Wang Y, Sivakumaran TA, Hagstrom SA et al. (2010).  Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.  Genes Immun 11, 609-621.

Wijsman EM, Rothstein JH, Igo RP Jr, Brunzell JD, Motulsky AG and Jarvik GP (2010). Linkage and association analysis identify a candidate region for apoB level on chromosome 4q32.3 in FCHL families. Hum Genet 127, 705-719.

Igo RP Jr, Luo Y and Li S (2010). Markov chain Monte Carlo linkage analysis: methods and software packages. In Handbook on Analyzing Human Genetic Data: Computational Approaches and Software, Springer-Verlag, New York.

Malhotra A, Igo RP Jr,, Thameem F, Kao WHL, Abboud HE, Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI et al. (2009). Genome-wide linnkage scans for type 2 diabetes mellitus in four ethnically diverse populations: significant evidence for linkage on chromosome 4q in African Americans. Diabetes Metab 25, 740-747.

Sinha R, Igo RP Jr, Saini SK, Elston RC and Luo Y (2009). Bayesian intervals for linkage locations. Genet Epidemiol 33, 604-616.

Igo RP Jr, Li J and Goddard KAB (2009). Association mapping by generalized linear regression with density-based haplotype clustering. Genet Epidemiol, 33, 16-26.


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