Jill S. Barnholtz-Sloan, PhD

Professor and Associate Director for Data Sciences/Translational Informatics | 216.368.1506 | Wolstein Research Bldg. 2526


Sally S. Morley Designated Professor in Brain Tumor Research, Department of Population and Quantitative Health Sciences
Associate Director for Data Sciences/Translational Informatics, Case Comprehensive Cancer Center and Cleveland Institute for Computational Biology
Case Western Reserve University School of Medicine

Director, Research Health Analytics and Informatics
University Hospitals Health System (UHHS)

Director, Cleveland Center for Health Outcomes Research (CCHOR)
Case Western Reserve University School of Medicine
Cleveland, Ohio



Ph.D., 2000, Biostatistics, University of Texas Health Science Center at Houston (UTHealth) School of Public Health
M.S., 1995, Statistics, University of Texas at Austin
B.S., 1994, Mathematics, University of Florida

Research Interests

Dr. Barnholtz-Sloan is multi-disciplinary researcher trained in biostatistics, population genetics, and human genetics. Her role in team science has been essential for multiple, successful multi-disciplinary research projects. She is the PI of the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA). She is also the scientific PI of the Central Brain Tumor Registry for the United States (CBTRUS). She has extensive experience with multi-site, brain tumor, patient recruitment and bio specimen collection, storage, and clinical annotation. She has multiple roles in the Case Western (CWRU) School of Medicine and the University Hospitals Health System (UHHS), which all focus on optimizing the use of data and analytics to advance health care.

At CWRU she is the Associate Director for Data Sciences at the Case Comprehensive Cancer Center and the Associate Director for Translational Informatics for the Cleveland Institute of Computational Biology. In these roles, she advances research endeavors by advocating for and assisting researchers in obtaining access to and using large health datasets (publicly available or controlled access) to answer research questions. Dr. Barnholtz-Sloan also aids investigators in the use of secure database infrastructure needed for human subjects’ research, the implementation of robust study designs, as well as the interpretation of results. These efforts aim to reduce the burden and barriers researchers may encounter in gaining access to and analyzing “big data”, enabling them to think about and perform research that has previously not been pursued.

As the Director for Research Health Analytics and Informatics at UHHS, she facilitates access to and analysis of UHHS data. Dr. Barnholtz-Sloan’s efforts focus on aiding clinicians in utilizing “big data” to impact clinical outcomes modeling that can drive both health operations and clinical decision making.

Dr. Barnholtz-Sloan is also Director of the Cleveland Center for Health Outcomes Research (CCHOR), which was established in the summer of 2018. The goal of the CCHOR is to integrate, innovate, and optimize the use of “big data”. CCHOR facilitates access to datasets and helps support analysis to test hypotheses and drive discoveries, facilitating understanding and impact on health.

Together, all of these roles draw upon her extensive experience in hypothesis development, study design and statistical analysis for studies of various phenotypes in humans and animals, and analysis of all types of high throughput “omics” and clinical outcomes data.

Professional Memberships

American Association of Cancer Research
North American Association for Cancer Registries
Society for Neuro Oncology

Recent Publications

  1. de Blank, P, Badve, C, Gold, DR, Stearns, D, Sunshine, J, Dastmalchian, S, Tomei, K, Sloan, AE, Barnholtz-Sloan, JS, Lane, A, Griswold, M, Gulani, V, Ma, D. Magnetic Resonance Fingerprinting to Characterize Childhood and Young Adult Brain Tumors. Pediatr Neurosurg 2019; : 1-9. PubMed PMID:31416081 .
  2. Mullins, MA, Peres, LC, Alberg, AJ, Bandera, EV, Barnholtz-Sloan, JS, Bondy, ML, Funkhouser, E, Moorman, PG, Peters, ES, Terry, PD, Schwartz, AG, Lawson, AB, Schildkraut, JM, Cote, ML. Perceived discrimination, trust in physicians, and prolonged symptom duration before ovarian cancer diagnosis in the African American Cancer Epidemiology Study. Cancer 2019; : . PubMed PMID:31415710 .
  3. Thiruvengadam, SS, OʼMalley, M, LaGuardia, L, Lopez, R, Wang, Z, Shadrach, BL, Chen, Y, Li, C, Veigl, ML, Barnholtz-Sloan, JS, Pai, RK, Church, JM, Kalady, MF, Walsh, RM, Burke, CA. Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis. Clin Transl Gastroenterol 2019; 10 (6): e00053. PubMed PMID:31211760 PubMed Central PMC6613862.
  4. Truitt, G, Gittleman, H, Leece, R, Ostrom, QT, Kruchko, C, Armstrong, TS, Gilbert, MR, Barnholtz-Sloan, JS. Partnership for defining the impact of 12 selected rare CNS tumors: a report from the CBTRUS and the NCI-CONNECT. J. Neurooncol. 2019; 144 (1): 53-63. PubMed PMID:31209773 .
  5. Cote, DJ, Ostrom, QT, Gittleman, H, Duncan, KR, CreveCoeur, TS, Kruchko, C, Smith, TR, Stampfer, MJ, Barnholtz-Sloan, JS. Glioma incidence and survival variations by county-level socioeconomic measures. Cancer 2019; : . PubMed PMID:31206646 .
  6. Wright, JM, Wright, CH, Cioffi, G, Raghavan, A, Hdeib, A, Kasliwal, MK, Kruchko, C, Barnholtz-Sloan, JS, Sloan, AE. Survival in Patients with High-Grade Spinal Meningioma: An Analysis of the National Cancer Database. World Neurosurg 2019; : . PubMed PMID:31203074 .
  7. Peres, LC, Hebert, JR, Qin, B, Guertin, KA, Bandera, EV, Shivappa, N, Camacho, TF, Chyn, D, Alberg, AJ, Barnholtz-Sloan, JS, Bondy, ML, Cote, ML, Funkhouser, E, Moorman, PG, Peters, ES, Schwartz, AG, Terry, PD, Schildkraut, JM. Prediagnostic Proinflammatory Dietary Potential Is Associated with All-Cause Mortality among African-American Women with High-Grade Serous Ovarian Carcinoma. J. Nutr. 2019; : . PubMed PMID:31152675 .
  8. Takahashi, H, Cornish, AJ, Sud, A, Law, PJ, Kinnersley, B, Ostrom, QT, Labreche, K, Eckel-Passow, JE, Armstrong, GN, Claus, EB, Il'yasova, D, Schildkraut, J, Barnholtz-Sloan, JS, Olson, SH, Bernstein, JL, Lai, RK, Schoemaker, MJ, Simon, M, Hoffmann, P, Nöthen, MM, Jöckel, KH, Chanock, S, Rajaraman, P, Johansen, C, Jenkins, RB, Melin, BS, Wrensch, MR, Sanson, M, Bondy, ML, Turnbull, C, Houlston, RS. Publisher Correction: Mendelian randomisation study of the relationship between vitamin D and risk of glioma. Sci Rep 2019; 9 (1): 7924. PubMed PMID:31118477 PubMed Central PMC6531429.
  9. Johansen, ML, Vincent, J, Gittleman, H, Craig, SEL, Couce, M, Sloan, AE, Barnholtz-Sloan, JS, Brady-Kalnay, SM. A PTPmu Biomarker is Associated with Increased Survival in Gliomas. Int J Mol Sci 2019; 20 (10): . PubMed PMID:31091655 PubMed Central PMC6566278.
  10. Yin, AA, He, YL, Etcheverry, A, Liu, YH, Aubry, M, Barnholtz-Sloan, J, Liu, BL, Mosser, J, Lu, ZF, Zhang, X. Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas. Clin Epigenetics 2019; 11 (1): 76. PubMed PMID:31088577 PubMed Central PMC6515684.
Search PubMed