Jill S. Barnholtz-Sloan, PhD

Professor and Associate Director for Bioinformatics/Translational Informatics | 216.368.1506 | Wolstein Research Bldg. 2526


Sally S. Morley Designated Professor in Brain Tumor Research, Department of Population and Quantitative Health Sciences
Associate Director for Bioinformatics/Translational Informatics, Case Comprehensive Cancer Center and Cleveland Institute for Computational Biology
Case Western Reserve University School of Medicine

Director, Research Health Analytics and Informatics
University Hospitals Health System (UHHS)

Director, Cleveland Center for Health Outcomes Research (CCHOR)
Case Western Reserve University School of Medicine
Cleveland, Ohio



Ph.D., 2000, Biostatistics, University of Texas Health Science Center at Houston (UTHealth) School of Public Health
M.S., 1995, Statistics, University of Texas at Austin
B.S., 1994, Mathematics, University of Florida

Research Interests

Dr. Barnholtz-Sloan is multi-disciplinary researcher trained in biostatistics, population genetics and human genetics. Her role in team science has been essential for multiple, successful multi-disciplinary research projects. She is the PI of the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA), and she is the scientific PI of the Central Brain Tumor Registry for the United States (CBTRUS). She has extensive experience with multi-site, brain tumor, patient recruitment and bio specimen collection, storage, and clinical annotation.

She is the Associate Director for Bioinformatics at the Case Comprehensive Cancer Center and the Associate Director for Translational Informatics for the Cleveland Institute of Computational Biology, both at Case Western Reserve University (CWRU) School of Medicine, where she is responsible for managing bioinformatics analysis of high throughput “omics” data and implementing and maintaining a translational informatics solution for research.

In addition, she is the Director for Research Health Analytics and Informatics at University Hospitals Health System (UHHS), a teaching affiliate of CWRU School of Medicine. There she helps facilitate access to and analysis of UHHS data for population health. She also serves as Director of the Cleveland Center for Health Outcomes Research (CCHOR) with a primary objective of optimizing “big data” for clinical outcomes modeling, including individualized patient predictions that would drive operational and clinical decision making.

All of this work draws on her extensive experience in hypothesis development, study design and statistical analysis for studies of various phenotypes in humans and animals and analysis of all types of high throughput “omics” data and clinical outcomes.

Professional Memberships

American Association of Cancer Research
North American Association for Cancer Registries
Society for Neuro Oncology

Recent Publications

  1. Thiruvengadam, SS, OʼMalley, M, LaGuardia, L, Lopez, R, Wang, Z, Shadrach, BL, Chen, Y, Li, C, Veigl, ML, Barnholtz-Sloan, JS, Pai, RK, Church, JM, Kalady, MF, Walsh, RM, Burke, CA. Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis. Clin Transl Gastroenterol 2019; : . PubMed PMID:31211760 .
  2. Truitt, G, Gittleman, H, Leece, R, Ostrom, QT, Kruchko, C, Armstrong, TS, Gilbert, MR, Barnholtz-Sloan, JS. Partnership for defining the impact of 12 selected rare CNS tumors: a report from the CBTRUS and the NCI-CONNECT. J. Neurooncol. 2019; : . PubMed PMID:31209773 .
  3. Cote, DJ, Ostrom, QT, Gittleman, H, Duncan, KR, CreveCoeur, TS, Kruchko, C, Smith, TR, Stampfer, MJ, Barnholtz-Sloan, JS. Glioma incidence and survival variations by county-level socioeconomic measures. Cancer 2019; : . PubMed PMID:31206646 .
  4. Wright, JM, Wright, CH, Cioffi, G, Raghavan, A, Hdeib, A, Kasliwal, MK, Kruchko, C, Barnholtz-Sloan, JS, Sloan, AE. Survival in Patients with High-Grade Spinal Meningioma: An Analysis of the National Cancer Database. World Neurosurg 2019; : . PubMed PMID:31203074 .
  5. Peres, LC, Hebert, JR, Qin, B, Guertin, KA, Bandera, EV, Shivappa, N, Camacho, TF, Chyn, D, Alberg, AJ, Barnholtz-Sloan, JS, Bondy, ML, Cote, ML, Funkhouser, E, Moorman, PG, Peters, ES, Schwartz, AG, Terry, PD, Schildkraut, JM. Prediagnostic Proinflammatory Dietary Potential Is Associated with All-Cause Mortality among African-American Women with High-Grade Serous Ovarian Carcinoma. J. Nutr. 2019; : . PubMed PMID:31152675 .
  6. Takahashi, H, Cornish, AJ, Sud, A, Law, PJ, Kinnersley, B, Ostrom, QT, Labreche, K, Eckel-Passow, JE, Armstrong, GN, Claus, EB, Il'yasova, D, Schildkraut, J, Barnholtz-Sloan, JS, Olson, SH, Bernstein, JL, Lai, RK, Schoemaker, MJ, Simon, M, Hoffmann, P, Nöthen, MM, Jöckel, KH, Chanock, S, Rajaraman, P, Johansen, C, Jenkins, RB, Melin, BS, Wrensch, MR, Sanson, M, Bondy, ML, Turnbull, C, Houlston, RS. Publisher Correction: Mendelian randomisation study of the relationship between vitamin D and risk of glioma. Sci Rep 2019; 9 (1): 7924. PubMed PMID:31118477 PubMed Central PMC6531429.
  7. Johansen, ML, Vincent, J, Gittleman, H, Craig, SEL, Couce, M, Sloan, AE, Barnholtz-Sloan, JS, Brady-Kalnay, SM. A PTPmu Biomarker is Associated with Increased Survival in Gliomas. Int J Mol Sci 2019; 20 (10): . PubMed PMID:31091655 PubMed Central PMC6566278.
  8. Yin, AA, He, YL, Etcheverry, A, Liu, YH, Aubry, M, Barnholtz-Sloan, J, Liu, BL, Mosser, J, Lu, ZF, Zhang, X. Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas. Clin Epigenetics 2019; 11 (1): 76. PubMed PMID:31088577 PubMed Central PMC6515684.
  9. Ascha, MS, Ostrom, QT, Wright, J, Kumthekar, P, Bordeaux, JS, Sloan, AE, Schumacher, FR, Kruchko, C, Barnholtz-Sloan, JS. Lifetime Occurrence of Brain Metastases Arising from Lung, Breast, and Skin Cancers in the Elderly: A SEER-Medicare Study. Cancer Epidemiol. Biomarkers Prev. 2019; 28 (5): 917-925. PubMed PMID:31053636 PubMed Central PMC6506177.
  10. Gittleman, H, Cioffi, G, Vecchione-Koval, T, Ostrom, QT, Kruchko, C, Osorio, DS, Finlay, JL, Barnholtz-Sloan, JS. Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015. J. Neurooncol. 2019; 143 (2): 251-260. PubMed PMID:31025275 .
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