Jill S. Barnholtz-Sloan, PhD

Professor and Associate Director for Bioinformatics/Translational Informatics | 216.368.1506 | Wolstein Research Bldg. 2526


Sally S. Morley Designated Professor in Brain Tumor Research, Department of Population and Quantitative Health Sciences
Associate Director for Bioinformatics/Translational Informatics, Case Comprehensive Cancer Center and Cleveland Institute for Computational Biology
Case Western Reserve University School of Medicine

Director, Research Health Analytics and Informatics
University Hospitals Health System (UHHS)

Director, Cleveland Center for Health Outcomes Research (CCHOR)
Case Western Reserve University School of Medicine
Cleveland, Ohio



Ph.D., 2000, Biostatistics, University of Texas Health Science Center at Houston (UTHealth) School of Public Health
M.S., 1995, Statistics, University of Texas at Austin
B.S., 1994, Mathematics, University of Florida

Research Interests

Dr. Barnholtz-Sloan is multi-disciplinary researcher trained in biostatistics, population genetics and human genetics. Her role in team science has been essential for multiple, successful multi-disciplinary research projects. She is the PI of the Ohio Brain Tumor Study (OBTS), which has served as a multi-site tissue source site for The Cancer Genome Atlas (TCGA), and she is the scientific PI of the Central Brain Tumor Registry for the United States (CBTRUS). She has extensive experience with multi-site, brain tumor, patient recruitment and bio specimen collection, storage, and clinical annotation.

She is the Associate Director for Bioinformatics at the Case Comprehensive Cancer Center and the Associate Director for Translational Informatics for the Cleveland Institute of Computational Biology, both at Case Western Reserve University (CWRU) School of Medicine, where she is responsible for managing bioinformatics analysis of high throughput “omics” data and implementing and maintaining a translational informatics solution for research.

In addition, she is the Director for Research Health Analytics and Informatics at University Hospitals Health System (UHHS), a teaching affiliate of CWRU School of Medicine. There she helps facilitate access to and analysis of UHHS data for population health. She also serves as Director of the Cleveland Center for Health Outcomes Research (CCHOR) with a primary objective of optimizing “big data” for clinical outcomes modeling, including individualized patient predictions that would drive operational and clinical decision making.

All of this work draws on her extensive experience in hypothesis development, study design and statistical analysis for studies of various phenotypes in humans and animals and analysis of all types of high throughput “omics” data and clinical outcomes.

Professional Memberships

American Association of Cancer Research
North American Association for Cancer Registries
Society for Neuro Oncology

Recent Publications

  1. Atkins, I, Kinnersley, B, Ostrom, QT, Labreche, K, Il'yasova, D, Armstrong, GN, Eckel-Passow, JE, Schoemaker, MJ, Nöthen, MM, Barnholtz-Sloan, JS, Swerdlow, AJ, Simon, M, Rajaraman, P, Chanock, SJ, Shildkraut, J, Bernstein, JL, Hoffmann, P, Jöckel, KH, Lai, RK, Claus, EB, Olson, SH, Johansen, C, Wrensch, MR, Melin, B, Jenkins, RB, Sanson, M, Bondy, ML, Houlston, RS. Transcriptome-wide association study identifies new candidate susceptibility genes for glioma. Cancer Res. 2019; : . PubMed PMID:30709929 .
  2. Barnholtz-Sloan, JS. Brain and central nervous system tumor statistics: access to accurate data for all countries is critical! Neuro-oncology 2019; : . PubMed PMID:30649531 .
  3. Walker, EV, Davis, FG, CBTR founding affiliates . Malignant primary brain and other central nervous system tumors diagnosed in Canada from 2009 to 2013. Neuro-oncology 2019; : . PubMed PMID:30649461 .
  4. Iorgulescu, JB, Torre, M, Harary, M, Smith, TR, Aizer, AA, Reardon, DA, Barnholtz-Sloan, JS, Perry, A. The Misclassification of Diffuse Gliomas: Rates and Outcomes. Clin. Cancer Res. 2019; : . PubMed PMID:30635340 .
  5. Yang, W, Warrington, NM, Taylor, SJ, Whitmire, P, Carrasco, E, Singleton, KW, Wu, N, Lathia, JD, Berens, ME, Kim, AH, Barnholtz-Sloan, JS, Swanson, KR, Luo, J, Rubin, JB. Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. Sci Transl Med 2019; 11 (473): . PubMed PMID:30602536 .
  6. Cui, T, Bell, EH, McElroy, J, Becker, AP, Gulati, PM, Geurts, M, Mladkova, N, Gray, A, Liu, K, Yang, L, Liu, Z, Fleming, JL, Haque, SJ, Barnholtz-Sloan, JS, Ligon, KL, Beroukhim, R, Robe, P, Chakravarti, A. miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma. Oncogene 2018; : . PubMed PMID:30559405 .
  7. Ostrom, QT, Gittleman, H, Kruchko, C, Barnholtz-Sloan, JS. Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival. J. Neurooncol. 2018; : . PubMed PMID:30543034 .
  8. Hulgan, T, Kallianpur, AR, Guo, Y, Barnholtz-Sloan, JS, Gittleman, H, Brown, TT, Ellis, R, Letendre, S, Heaton, RK, Samuels, DC, CHARTER Study. Peripheral blood mitochondrial DNA copy number obtained from genome-wide genotype data is associated with neurocognitive impairment in persons with chronic HIV infection. J. Acquir. Immune Defic. Syndr. 2018; : . PubMed PMID:30531306 .
  9. Amirian, ES, Ostrom, QT, Armstrong, GN, Lai, RK, Gu, X, Jacobs, DI, Jalali, A, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, JM, Ali-Osman, F, Sadetzki, S, Jenkins, RB, LaChance, DH, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Johansen, C, Houlston, RS, Scheurer, ME, Shete, S, Amos, CI, Melin, B, Bondy, ML. Aspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-Analysis. Cancer Epidemiol. Biomarkers Prev. 2018; : . PubMed PMID:30482874 .
  10. Moorman, PG, Barrett, NJ, Wang, F, Alberg, JA, Bandera, EV, Barnholtz-Sloan, JB, Bondy, M, Cote, ML, Funkhouser, E, Kelemen, LE, Peres, LC, Peters, ES, Schwartz, AG, Terry, PD, Crankshaw, S, Abbott, SE, Schildkraut, JM. Effect of Cultural, Folk, and Religious Beliefs and Practices on Delays in Diagnosis of Ovarian Cancer in African American Women. J Womens Health (Larchmt) 2018; : . PubMed PMID:30481095 .
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