jonathan_cropped

Jonathan L. Haines, PhD

Mary W. Sheldon MD Professor of Genomic Sciences, Chair

jonathan.haines@case.edu | 216.368.2478 | Wolstein Research Bldg., Rm 2528

Education

Recent Publications

  1. Gusareva, ES, Twizere, JC, Sleegers, K, Dourlen, P, Abisambra, JF, Meier, S, Cloyd, R, Weiss, B, Dermaut, B, Bessonov, K, van der Lee, SJ, Carrasquillo, MM, Katsumata, Y, Cherkaoui, M, Asselbergh, B, Ikram, MA, Mayeux, R, Farrer, LA, Haines, JL, Pericak-Vance, MA, Schellenberg, GD, Genetic and Environmental Risk in Alzheimer's Disease 1 consortium (GERAD1), Alzheimer's Disease Genetics Consortium (ADGC), European Alzheimer Disease Initiative Investigators (EADI1 Consortium), Sims, R, Williams, J, Amouyel, P, van Duijn, CM, Ertekin-Taner, N, Van Broeckhoven, C, Dequiedt, F, Fardo, DW, Lambert, JC, Van Steen, K. Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiol. Aging 2018; : . PubMed PMID:30201328 .
  2. Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE, Marcora, E, Farrell, JJ, Zhao, Y, Qu, L, Ahmad, S, Amin, N, Amouyel, P, Beecham, GW, Below, JE, Campion, D, Charbonnier, C, Chung, J, Crane, PK, Cruchaga, C, Cupples, LA, Dartigues, JF, Debette, S, Deleuze, JF, Fulton, L, Gabriel, SB, Genin, E, Gibbs, RA, Goate, A, Grenier-Boley, B, Gupta, N, Haines, JL, Havulinna, AS, Helisalmi, S, Hiltunen, M, Howrigan, DP, Ikram, MA, Kaprio, J, Konrad, J, Kuzma, A, Lander, ES, Lathrop, M, Lehtimäki, T, Lin, H, Mattila, K, Mayeux, R, Muzny, DM, Nasser, W, Neale, B, Nho, K, Nicolas, G, Patel, D, Pericak-Vance, MA, Perola, M, Psaty, BM, Quenez, O, Rajabli, F, Redon, R, Reitz, C, Remes, AM, Salomaa, V, Sarnowski, C, Schmidt, H, Schmidt, M, Schmidt, R, Soininen, H, Thornton, TA, Tosto, G, Tzourio, C, van der Lee, SJ, van Duijn, CM, Vardarajan, B, Wang, W, Wijsman, E, Wilson, RK, Witten, D, Worley, KC, Zhang, X, Alzheimer’s Disease Sequencing Project, Bellenguez, C, Lambert, JC, Kurki, MI, Palotie, A, Daly, M, Boerwinkle, E, Lunetta, KL, Destefano, AL, Dupuis, J, Martin, ER, Schellenberg, GD, Seshadri, S, Naj, AC, Fornage, M, Farrer, LA. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol. Psychiatry 2018; : . PubMed PMID:30108311 .
  3. Vardarajan, BN, Beecham, GW, Haines, JL. Pedigree Selection and Information Content. Curr Protoc Hum Genet 2018; 97 (1): e56. PubMed PMID:30040223 .
  4. Deming, Y, Dumitrescu, L, Barnes, LL, Thambisetty, M, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL, Kukull, W, Huentelman, M, Crane, PK, Resnick, SM, Keene, CD, Montine, TJ, Schellenberg, GD, Haines, JL, Zetterberg, H, Blennow, K, Larson, EB, Johnson, SC, Albert, M, Moghekar, A, Del Aguila, JL, Fernandez, MV, Budde, J, Hassenstab, J, Fagan, AM, Riemenschneider, M, Petersen, RC, Minthon, L, Chao, MJ, Van Deerlin, VM, Lee, VM, Shaw, LM, Trojanowski, JQ, Peskind, ER, Li, G, Davis, LK, Sealock, JM, Cox, NJ, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetics Consortium (ADGC), Goate, AM, Bennett, DA, Schneider, JA, Jefferson, AL, Cruchaga, C, Hohman, TJ. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018; : . PubMed PMID:29967939 .
  5. Fan, BJ, Chen, X, Sondhi, N, Sharmila, PF, Soumittra, N, Sripriya, S, Sacikala, S, Asokan, R, Friedman, DS, Pasquale, LR, Gao, XR, Vijaya, L, Cooke Bailey, J, Vitart, V, MacGregor, S, Hammond, CJ, Khor, CC, Haines, JL, George, R, Wiggs, JL, Mexican American Glaucoma Genetic Study; International Glaucoma Genetics Consortium; and NEIGHBORHOOD Consortium. Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus. Invest. Ophthalmol. Vis. Sci. 2018; 59 (6): 2495-2502. PubMed PMID:29847655 PubMed Central PMC5961220.
  6. Hohman, TJ, Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL, Kukull, W, Crane, PK, Resnick, SM, Keene, CD, Montine, TJ, Schellenberg, GD, Haines, JL, Zetterberg, H, Blennow, K, Larson, EB, Johnson, SC, Albert, M, Bennett, DA, Schneider, JA, Jefferson, AL, Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative. Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol 2018; 75 (8): 989-998. PubMed PMID:29801024 .
  7. Khawaja, AP, Cooke Bailey, JN, Wareham, NJ, Scott, RA, Simcoe, M, Igo, RP Jr, Song, YE, Wojciechowski, R, Cheng, CY, Khaw, PT, Pasquale, LR, Haines, JL, Foster, PJ, Wiggs, JL, Hammond, CJ, Hysi, PG, UK Biobank Eye and Vision Consortium, NEIGHBORHOOD Consortium. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat. Genet. 2018; 50 (6): 778-782. PubMed PMID:29785010 PubMed Central PMC5985943.
  8. Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Höhn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE, Li, X, Yazar, S, Nag, A, Khawaja, AP, Polašek, O, Siscovick, D, Mitchell, P, Tham, YC, Haines, JL, Kearns, LS, Hayward, C, Shi, Y, van Leeuwen, EM, Taylor, KD, Blue Mountains Eye Study—GWAS group, Bonnemaijer, P, Rotter, JI, Martin, NG, Zeller, T, Mills, RA, Staffieri, SE, Jonas, JB, Schmidtmann, I, Boutin, T, Kang, JH, Lucas, SEM, Wong, TY, Beutel, ME, Wilson, JF, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Uitterlinden, AG, Vithana, EN, Foster, PJ, Hysi, PG, Hewitt, AW, Khor, CC, Pasquale, LR, Montgomery, GW, Klaver, CCW, Aung, T, Pfeiffer, N, Mackey, DA, Hammond, CJ, Cheng, CY, Craig, JE, Rabinowitz, YS, Wiggs, JL, Burdon, KP, van Duijn, CM, MacGregor, S. Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nat Commun 2018; 9 (1): 1864. PubMed PMID:29760442 PubMed Central PMC5951816.
  9. Nittala, MG, Song, YE, Sardell, R, Adams, LD, Pan, S, Velaga, SB, Horst, V, Dana, D, Caywood, L, Laux, R, Fuzzell, D, Fuzzell, S, Scott, WK, Cooke Bailey, JN, Igo, RP Jr, Haines, J, Pericak-Vance, MA, Sadda, SR, Stambolian, D. AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration. Retina (Philadelphia, Pa.) 2018; : . PubMed PMID:29746403 .
  10. Hou, L, Kember, RL, Roach, JC, O'Connell, JR, Craig, DW, Bucan, M, Scott, WK, Pericak-Vance, M, Haines, JL, Crawford, MH, Shuldiner, AR, McMahon, FJ. Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations. Sci Rep 2018; 8 (1): 6771. PubMed PMID:29691419 PubMed Central PMC5915589.
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