jonathan_cropped

Jonathan L. Haines, PhD

Mary W. Sheldon MD Professor of Genomic Sciences and Chair

jonathan.haines@case.edu | 216.368.2478 | Wolstein Research Bldg., Rm 2528

 

Education

1979, BA               Colby College (Biology)

1984, PhD            University of Minnesota (Genetics & Cell Biology)

Dr. Haines is an internationally recognized researcher and educator with extensive experience in all aspects of genetic epidemiology, the study of the role of genes and the environment in human health and disease.

His research focus is big data analytics, with exper­tise in dis­or­ders of the eye and nervous system. Dr. Haines has located more than 20 causal and 200 asso­ci­ated genetic loci and has helped to define the genetic architecture of aging diseases, including macular degeneration and Alzheimer’s disease.

He emphasizes diversity in genetic sampling and a comprehensive view of data analytics. By applying sophisticated, com­pu­ta­tional meth­ods to large data sets, he seeks to discover contributing factors to diseases and chronic conditions, with an aim of improving patient care and community health.

Dr. Haines founded and directs the Cleveland Insti­tute for Com­pu­ta­tional Biol­ogy, a collaboration between Case Western Reserve University School of Medicine, University Hospitals Cleveland, and Cleveland Clinic. The Institute applies computational methods to large sets of patient data in order to improve the prevention, diagnosis, and treatment of disease.

Dr. Haines serves on a number of professional advisory councils including the National Institute of Health’s National Advisory Council for Human Genome Research, the scientific advisory panel for the NIH’s National Human Genome Research Institute Genome Sequencing Program, the board of directors for the National Organization for Rare Disorders, and the executive committee of the NIH’s Alzheimer’s Disease Sequencing Project. He serves on the editorial boards of Neurogenetics, Human Molecular Genetics, and Nature Genomic Medicine.

Before coming to Case Western Reserve University, Dr. Haines was at Harvard Medical School and was professor of molecular physiology and biophysics at Vanderbilt School of Medicine, with joint appointments in several departments. At Vanderbilt he was chief of the Division of Human Genomics and founding director of the Center for Human Genetics Research.

Recent Publications

  1. Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser, MA, Allingham, RR, Aung, T, Van Der Heide, CJ, Taylor, KD, Rotter, JI, Wang, SJ, Bonnemaijer, PWM, Williams, SE, Abdullahi, SM, Abu-Amero, KK, Anderson, MG, Akafo, S, Alhassan, MB, Asimadu, I, Ayyagari, R, Bakayoko, S, Nyamsi, PB, Bowden, DW, Bromley, WC, Budenz, DL, Carmichael, TR, Challa, P, Chen, YI, Chuka-Okosa, CM, Cooke Bailey, JN, Costa, VP, Cruz, DA, DuBiner, H, Ervin, JF, Feldman, RM, Flamme-Wiese, M, Gaasterland, DE, Garnai, SJ, Girkin, CA, Guirou, N, Guo, X, Haines, JL, Hammond, CJ, Herndon, L, Hoffmann, TJ, Hulette, CM, Hydara, A, Igo, RP Jr, Jorgenson, E, Kabwe, J, Kilangalanga, NJ, Kizor-Akaraiwe, N, Kuchtey, RW, Lamari, H, Li, Z, Liebmann, JM, Liu, Y, Loos, RJF, Melo, MB, Moroi, SE, Msosa, JM, Mullins, RF, Nadkarni, G, Napo, A, Ng, MCY, Nunes, HF, Obeng-Nyarkoh, E, Okeke, A, Okeke, S, Olaniyi, O, Olawoye, O, Oliveira, MB, Pasquale, LR, Perez-Grossmann, RA, Pericak-Vance, MA, Qin, X, Ramsay, M, Resnikoff, S, Richards, JE, Schimiti, RB, Sim, KS, Sponsel, WE, Svidnicki, PV, Thiadens, AAHJ, Uche, NJ, van Duijn, CM, de Vasconcellos, JPC, Wiggs, JL, Zangwill, LM, Risch, N, Milea, D, Ashaye, A, Klaver, CCW, Weinreb, RN, Ashley Koch, AE, Fingert, JH, Khor, CC. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. JAMA 2019; 322 (17): 1682-1691. PubMed PMID:31688885 .
  2. Bis, JC, Jian, X, Kunkle, BW, Chen, Y, Hamilton-Nelson, KL, Bush, WS, Salerno, WJ, Lancour, D, Ma, Y, Renton, AE, Marcora, E, Farrell, JJ, Zhao, Y, Qu, L, Ahmad, S, Amin, N, Amouyel, P, Beecham, GW, Below, JE, Campion, D, Cantwell, L, Charbonnier, C, Chung, J, Crane, PK, Cruchaga, C, Cupples, LA, Dartigues, JF, Debette, S, Deleuze, JF, Fulton, L, Gabriel, SB, Genin, E, Gibbs, RA, Goate, A, Grenier-Boley, B, Gupta, N, Haines, JL, Havulinna, AS, Helisalmi, S, Hiltunen, M, Howrigan, DP, Ikram, MA, Kaprio, J, Konrad, J, Kuzma, A, Lander, ES, Lathrop, M, Lehtimäki, T, Lin, H, Mattila, K, Mayeux, R, Muzny, DM, Nasser, W, Neale, B, Nho, K, Nicolas, G, Patel, D, Pericak-Vance, MA, Perola, M, Psaty, BM, Quenez, O, Rajabli, F, Redon, R, Reitz, C, Remes, AM, Salomaa, V, Sarnowski, C, Schmidt, H, Schmidt, M, Schmidt, R, Soininen, H, Thornton, TA, Tosto, G, Tzourio, C, van der Lee, SJ, van Duijn, CM, Valladares, O, Vardarajan, B, Wang, LS, Wang, W, Wijsman, E, Wilson, RK, Witten, D, Worley, KC, Zhang, X, Alzheimer’s Disease Sequencing Project, Bellenguez, C, Lambert, JC, Kurki, MI, Palotie, A, Daly, M, Boerwinkle, E, Lunetta, KL, Destefano, AL, Dupuis, J, Martin, ER, Schellenberg, GD, Seshadri, S, Naj, AC, Fornage, M, Farrer, LA. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Mol. Psychiatry 2019; : . PubMed PMID:31636380 .
  3. Velaga, SB, Nittala, MG, Vupparaboina, KK, Jana, S, Chhablani, J, Haines, J, Pericak-Vance, MA, Stambolian, D, Sadda, SR. CHOROIDAL VASCULARITY INDEX AND CHOROIDAL THICKNESS IN EYES WITH RETICULAR PSEUDODRUSEN. Retina (Philadelphia, Pa.) 2019; : . PubMed PMID:31634322 .
  4. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN, International Age-Related Macular Degeneration Genomics Consortium. Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2019; 60 (12): 4041-4051. PubMed PMID:31560769 PubMed Central PMC6779289.
  5. Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Bush, WS, Gifford, KA, Chibnik, LB, Mukherjee, S, De Jager, PL, Kukull, W, Crane, PK, Resnick, SM, Keene, CD, Montine, TJ, Schellenberg, GD, Deming, Y, Chao, MJ, Huentelman, M, Martin, ER, Hamilton-Nelson, K, Shaw, LM, Trojanowski, JQ, Peskind, ER, Cruchaga, C, Pericak-Vance, MA, Goate, AM, Cox, NJ, Haines, JL, Zetterberg, H, Blennow, K, Larson, EB, Johnson, SC, Albert, M, Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, Bennett, DA, Schneider, JA, Jefferson, AL, Hohman, TJ. Sex differences in the genetic predictors of Alzheimer's pathology. Brain 2019; 142 (9): 2581-2589. PubMed PMID:31497858 PubMed Central PMC6736148.
  6. Fan, BJ, Bailey, JC, Igo, RP Jr, Kang, JH, Boumenna, T, Brilliant, MH, Budenz, DL, Fingert, JH, Gaasterland, T, Gaasterland, D, Hauser, MA, Kraft, P, Lee, RK, Lichter, PR, Liu, Y, Moroi, SE, Myers, JS, Pericak-Vance, MA, Realini, A, Rhee, DJ, Richards, JE, Ritch, R, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Vollrath, D, Weinreb, RN, Wollstein, G, Zack, DJ, Haines, JL, Pasquale, LR, Wiggs, JL. Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis. JAMA Ophthalmol 2019; : . PubMed PMID:31436842 PubMed Central PMC6707005.
  7. Choi, KY, Lee, JJ, Gunasekaran, TI, Kang, S, Lee, W, Jeong, J, Lim, HJ, Zhang, X, Zhu, C, Won, SY, Choi, YY, Seo, EH, Lee, SC, Gim, J, Chung, JY, Chong, A, Byun, MS, Seo, S, Ko, PW, Han, JW, McLean, C, Farrell, J, Lunetta, KL, Miyashita, A, Hara, N, Won, S, Choi, SM, Ha, JM, Jeong, JH, Kuwano, R, Song, MK, An, SSA, Lee, YM, Park, KW, Lee, HW, Choi, SH, Rhee, S, Song, WK, Lee, JS, Mayeux, R, Haines, JL, Pericak-Vance, MA, Choo, ILH, Nho, K, Kim, KW, Lee, DY, Kim, S, Kim, BC, Kim, H, Jun, GR, Schellenberg, GD, Ikeuchi, T, Farrer, LA, Lee, KH, Neuroimaging Initative, AD. APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer's Disease Risk in a Multiracial Sample. J Clin Med 2019; 8 (8): . PubMed PMID:31426376 PubMed Central PMC6723529.
  8. Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A, Bellenguez, C, Frizatti, A, Chouraki, V, Martin, ER, Sleegers, K, Badarinarayan, N, Jakobsdottir, J, Hamilton-Nelson, KL, Moreno-Grau, S, Olaso, R, Raybould, R, Chen, Y, Kuzma, AB, Hiltunen, M, Morgan, T, Ahmad, S, Vardarajan, BN, Epelbaum, J, Hoffmann, P, Boada, M, Beecham, GW, Garnier, JG, Harold, D, Fitzpatrick, AL, Valladares, O, Moutet, ML, Gerrish, A, Smith, AV, Qu, L, Bacq, D, Denning, N, Jian, X, Zhao, Y, Del Zompo, M, Fox, NC, Choi, SH, Mateo, I, Hughes, JT, Adams, HH, Malamon, J, Sanchez-Garcia, F, Patel, Y, Brody, JA, Dombroski, BA, Naranjo, MCD, Daniilidou, M, Eiriksdottir, G, Mukherjee, S, Wallon, D, Uphill, J, Aspelund, T, Cantwell, LB, Garzia, F, Galimberti, D, Hofer, E, Butkiewicz, M, Fin, B, Scarpini, E, Sarnowski, C, Bush, WS, Meslage, S, Kornhuber, J, White, CC, Song, Y, Barber, RC, Engelborghs, S, Sordon, S, Voijnovic, D, Adams, PM, Vandenberghe, R, Mayhaus, M, Cupples, LA, Albert, MS, De Deyn, PP, Gu, W, Himali, JJ, Beekly, D, Squassina, A, Hartmann, AM, Orellana, A, Blacker, D, Rodriguez-Rodriguez, E, Lovestone, S, Garcia, ME, Doody, RS, Munoz-Fernadez, C, Sussams, R, Lin, H, Fairchild, TJ, Benito, YA, Holmes, C, Karamujić-Čomić, H, Frosch, MP, Thonberg, H, Maier, W, Roshchupkin, G, Ghetti, B, Giedraitis, V, Kawalia, A, Li, S, Huebinger, RM, Kilander, L, Moebus, S, Hernández, I, Kamboh, MI, Brundin, R, Turton, J, Yang, Q, Katz, MJ, Concari, L, Lord, J, Beiser, AS, Keene, CD, Helisalmi, S, Kloszewska, I, Kukull, WA, Koivisto, AM, Lynch, A, Tarraga, L, Larson, EB, Haapasalo, A, Lawlor, B, Mosley, TH, Lipton, RB, Solfrizzi, V, Gill, M, Longstreth, WT Jr, Montine, TJ, Frisardi, V, Diez-Fairen, M, Rivadeneira, F, Petersen, RC, Deramecourt, V, Alvarez, I, Salani, F, Ciaramella, A, Boerwinkle, E, Reiman, EM, Fievet, N, Rotter, JI, Reisch, JS, Hanon, O, Cupidi, C, Uitterlinden, AGA, Royall, DR, Dufouil, C, Maletta, RG, de Rojas, I, Sano, M, Brice, A, Cecchetti, R, George-Hyslop, PS, Ritchie, K, Tsolaki, M, Tsuang, DW, Dubois, B, Craig, D, Wu, CK, Soininen, H, Avramidou, D, Albin, RL, Fratiglioni, L, Germanou, A, Apostolova, LG, Keller, L, Koutroumani, M, Arnold, SE, Panza, F, Gkatzima, O, Asthana, S, Hannequin, D, Whitehead, P, Atwood, CS, Caffarra, P, Hampel, H, Quintela, I, Carracedo, Á, Lannfelt, L, Rubinsztein, DC, Barnes, LL, Pasquier, F, Frölich, L, Barral, S, McGuinness, B, Beach, TG, Johnston, JA, Becker, JT, Passmore, P, Bigio, EH, Schott, JM, Bird, TD, Warren, JD, Boeve, BF, Lupton, MK, Bowen, JD, Proitsi, P, Boxer, A, Powell, JF, Burke, JR, Kauwe, JSK, Burns, JM, Mancuso, M, Buxbaum, JD, Bonuccelli, U, Cairns, NJ, McQuillin, A, Cao, C, Livingston, G, Carlson, CS, Bass, NJ, Carlsson, CM, Hardy, J, Carney, RM, Bras, J, Carrasquillo, MM, Guerreiro, R, Allen, M, Chui, HC, Fisher, E, Masullo, C, Crocco, EA, DeCarli, C, Bisceglio, G, Dick, M, Ma, L, Duara, R, Graff-Radford, NR, Evans, DA, Hodges, A, Faber, KM, Scherer, M, Fallon, KB, Riemenschneider, M, Fardo, DW, Heun, R, Farlow, MR, Kölsch, H, Ferris, S, Leber, M, Foroud, TM, Heuser, I, Galasko, DR, Giegling, I, Gearing, M, Hüll, M, Geschwind, DH, Gilbert, JR, Morris, J, Green, RC, Mayo, K, Growdon, JH, Feulner, T, Hamilton, RL, Harrell, LE, Drichel, D, Honig, LS, Cushion, TD, Huentelman, MJ, Hollingworth, P, Hulette, CM, Hyman, BT, Marshall, R, Jarvik, GP, Meggy, A, Abner, E, Menzies, GE, Jin, LW, Leonenko, G, Real, LM, Jun, GR, Baldwin, CT, Grozeva, D, Karydas, A, Russo, G, Kaye, JA, Kim, R, Jessen, F, Kowall, NW, Vellas, B, Kramer, JH, Vardy, E, LaFerla, FM, Jöckel, KH, Lah, JJ, Dichgans, M, Leverenz, JB, Mann, D, Levey, AI, Pickering-Brown, S, Lieberman, AP, Klopp, N, Lunetta, KL, Wichmann, HE, Lyketsos, CG, Morgan, K, Marson, DC, Brown, K, Martiniuk, F, Medway, C, Mash, DC, Nöthen, MM, Masliah, E, Hooper, NM, McCormick, WC, Daniele, A, McCurry, SM, Bayer, A, McDavid, AN, Gallacher, J, McKee, AC, van den Bussche, H, Mesulam, M, Brayne, C, Miller, BL, Riedel-Heller, S, Miller, CA, Miller, JW, Al-Chalabi, A, Morris, JC, Shaw, CE, Myers, AJ, Wiltfang, J, O'Bryant, S, Olichney, JM, Alvarez, V, Parisi, JE, Singleton, AB, Paulson, HL, Collinge, J, Perry, WR, Mead, S, Peskind, E, Cribbs, DH, Rossor, M, Pierce, A, Ryan, NS, Poon, WW, Nacmias, B, Potter, H, Sorbi, S, Quinn, JF, Sacchinelli, E, Raj, A, Spalletta, G, Raskind, M, Caltagirone, C, Bossù, P, Orfei, MD, Reisberg, B, Clarke, R, Reitz, C, Smith, AD, Ringman, JM, Warden, D, Roberson, ED, Wilcock, G, Rogaeva, E, Bruni, AC, Rosen, HJ, Gallo, M, Rosenberg, RN, Ben-Shlomo, Y, Sager, MA, Mecocci, P, Saykin, AJ, Pastor, P, Cuccaro, ML, Vance, JM, Schneider, JA, Schneider, LS, Slifer, S, Seeley, WW, Smith, AG, Sonnen, JA, Spina, S, Stern, RA, Swerdlow, RH, Tang, M, Tanzi, RE, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Van Eldik, LJ, Vinters, HV, Vonsattel, JP, Weintraub, S, Welsh-Bohmer, KA, Wilhelmsen, KC, Williamson, J, Wingo, TS, Woltjer, RL, Wright, CB, Yu, CE, Yu, L, Saba, Y, Alzheimer Disease Genetics Consortium (ADGC), European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Pilotto, A, Bullido, MJ, Peters, O, Crane, PK, Bennett, D, Bosco, P, Coto, E, Boccardi, V, De Jager, PL, Lleo, A, Warner, N, Lopez, OL, Ingelsson, M, Deloukas, P, Cruchaga, C, Graff, C, Gwilliam, R, Fornage, M, Goate, AM, Sanchez-Juan, P, Kehoe, PG, Amin, N, Ertekin-Taner, N, Berr, C, Debette, S, Love, S, Launer, LJ, Younkin, SG, Dartigues, JF, Corcoran, C, Ikram, MA, Dickson, DW, Nicolas, G, Campion, D, Tschanz, J, Schmidt, H, Hakonarson, H, Clarimon, J, Munger, R, Schmidt, R, Farrer, LA, Van Broeckhoven, C, O'Donovan, MC, DeStefano, AL, Jones, L, Haines, JL, Deleuze, JF, Owen, MJ, Gudnason, V, Mayeux, R, Escott-Price, V, Psaty, BM, Ramirez, A, Wang, LS, Ruiz, A, van Duijn, CM, Holmans, PA, Seshadri, S, Williams, J, Amouyel, P, Schellenberg, GD, Lambert, JC, Pericak-Vance, MA. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat. Genet. 2019; 51 (9): 1423-1424. PubMed PMID:31417202 .
  9. Waksmunski, AR, Igo, RP Jr, Song, YE, Cooke Bailey, JN, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M, Stambolian, D, Scott, WK, Pericak-Vance, MA, Haines, JL. Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. Hum. Genet. 2019; 138 (10): 1171-1182. PubMed PMID:31367973 PubMed Central PMC6745026.
  10. Ma, Y, Jun, GR, Zhang, X, Chung, J, Naj, AC, Chen, Y, Bellenguez, C, Hamilton-Nelson, K, Martin, ER, Kunkle, BW, Bis, JC, Debette, S, DeStefano, AL, Fornage, M, Nicolas, G, van Duijn, C, Bennett, DA, De Jager, PL, Mayeux, R, Haines, JL, Pericak-Vance, MA, Seshadri, S, Lambert, JC, Schellenberg, GD, Lunetta, KL, Farrer, LA, Alzheimer’s Disease Sequencing Project and Alzheimer’s Disease Exome Sequencing–France Project. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA Neurol 2019; : . PubMed PMID:31180460 PubMed Central PMC6563544.
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