Recent activities

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10/24/2019: Elina presented at the Biomedical Graduate Student Symposium here at CWRU. She shared findings from a Mendelian randomization analysis of the causal genetic relationships between body mass index and multiple sclerosis risk and presentation.

10/18/2019: Dr. Briggs presented on behalf of colleagues at Brighman Young University and Biogen, results from a large genetic study of age of onset of multiple sclerosis during the poster session at the annual meeting for The American Society of Human Genetics held in Houston, TX.

09/27/2019: Today in Science, Dr. Briggs wrote a commentary on two recent large genetic studies of multiple sclerosis (MS) risk conducted by the International MS Genetics Consortium.

09/09/2019: Dr. Briggs gave an invited presentation on things to consider before returning sequence level genetic data to research participants at the North Coast Conference on Precision Medicine.

07/24/2019: Today another lab paper was published. Dr. Briggs and Eddie estimated that there are >800,000 Americans living with MS using 56.6 million electronic health records and US census data. The findings support early-2019 studies of administrative health claims data. These estimate near double the pre-2019 MS prevalence.

06/03/2019: Dr. Briggs and fellow PQHS faculty members, Drs. Crawford and Cooke-Bailey, had a review article published in Human Genetics.  In this review, they summarized the resources required to receive, process, and interpret return of large-scale genetic/genomic research results to study participants, and highlighted the potential for access disparities and warned the scientific community to mind the gap so that all participants have equal access and understanding of the benefits of human genetic research.

05/09/2019: Dr. Briggs presented at the 71st Annual Meeting of the American Academy of Neurology. His presentation was titled Multiple sclerosis genetic risk burden confers earlier onset, and part of the MS Epidemiology and Risk Stratification session.

05/02/2019: Dr. Briggs and Dr. Milena Gianfranceso had a commentary on obesity and pediatric multiple sclerosis published in Developmental Medicine & Child Neurology.

04/19/2019: Corri presented her work at CWRU’s 2019 Intersections. Corri conducted a series of survival analyses investigating the role of multiple sclerosis genetic and non-genetic risk factors on disease progression.

03/14/2019: Another NDGE paper is out, this was work in close collaboration with our colleagues at the Duke Center for Research in Autoimmunity and Multiple Sclerosis (DREAMS). This project was a comprehensive metabolomic profiling of men with and without MS. Genetic and genomic data were available to guide interpretations.

03/08/2019: Medscape Medical News reported on Eddie’s publication on asthma in MS.

03/06/2019: The team presented 5 posters at Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2019  in Dallas. Elina, Frances and Eddie were all recipients of the Educational Travel Award and we able to present their posters! Jordan’s and Blaine’s projects were incorporated into two additional NDGE posters.

02/05/2019: Another lab paper out today on Eddie’s work on asthma in MS.

02/01/2019: Today another paper was published. This study assessed the impact of MS risk factors on MS presentation near onset and built on Justin’s work from 2017-2018. Of note, MS genetic risk was associated with early age of onset. Parts of this work was supported by the National Multiple Sclerosis Society (PP-1703-27359).

01/29/2019: Today the lab’s paper on factors influencing walking impairment, dexterity, and perceived disability was published. In brief, higher body mass index, smoking, lower socio-economic status, and being on Medicare/Medicaid were also were poorer outcomes.

01/29/2019: Dr. Briggs was a guest on RealTalk MS podcast. Episode 75 (January 2019). “MS Risk Factors

12/17/2018: MS News today reported on a lab’s forthcoming publication: “Each Major Risk Factor (Like Genes, Smoking and Obesity) Can Affect Disease Course, Study Finds

12/14/2018: Dr. Briggs gave a seminar at the Center for Health Care Research and Policy (CHRP) on phenotypic heterogeneity in MS.

12/03/2018: Elina presented in the PQHS 501 seminar on her work investigating factors influencing transition from relapsing remitting MS to secondary progressive MS.

9/20/2018: Eddie presented a poster on his asthma in MS project at the SOM’s Lepow Day

06/01/2018: Dr. Briggs was awarded Best Platform in MS Research at the 2018 Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting in Nashville. He presented on the impact of obesity on the clinical presentation of MS at onset

04/25/2018: Dr. Briggs and colleagues from the Cleveland Clinic presented a poster on prognostic factors of disability and depression in patients with MS at the American Academy of Neurology 2018 Annual Meeting in Los Angeles.

02/1/2018: The team presented 3 posters at Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2018  in San Diego. Jinghong was a finalist and Justin was a semifinalist for Best Trainee Poster and we recipients of the Education Travel Award.