Rob Igo_crop

Rob Igo, PhD

Assistant Professor

rpi@.case.edu | 216.368.4562 | Wolstein Research Bldg. Rm. 1302

Education

B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005

Research Interests

I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, age-related macular degeneration and susceptibility to tuberculosis.

Professional Memberships

American Society of Human Genetics
International Genetic Epidemiology Society

Courses Taught

EPBI 452: Statistical Methods for Genetic Epidemiology
EPBI 502: Genetic Epidemiology Seminar

Recent Publications

  1. Papp, AC, Azad, AK, Pietrzak, M, Williams, A, Handelman, SK, Igo, RP Jr, Stein, CM, Hartmann, K, Schlesinger, LS, Sadee, W. AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection. PLoS ONE 2018; 13 (5): e0198221. PubMed PMID:29847580 PubMed Central PMC5976201.
  2. Tedja, MS, Wojciechowski, R, Hysi, PG, Eriksson, N, Furlotte, NA, Verhoeven, VJM, Iglesias, AI, Meester-Smoor, MA, Tompson, SW, Fan, Q, Khawaja, AP, Cheng, CY, Höhn, R, Yamashiro, K, Wenocur, A, Grazal, C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, JB, Wang, YX, Xie, J, Mitchell, P, Foster, PJ, Klein, BEK, Klein, R, Paterson, AD, Hosseini, SM, Shah, RL, Williams, C, Teo, YY, Tham, YC, Gupta, P, Zhao, W, Shi, Y, Saw, WY, Tai, ES, Sim, XL, Huffman, JE, Polašek, O, Hayward, C, Bencic, G, Rudan, I, Wilson, JF, CREAM Consortium, 23andMe Research Team, UK Biobank Eye and Vision Consortium, Joshi, PK, Tsujikawa, A, Matsuda, F, Whisenhunt, KN, Zeller, T, van der Spek, PJ, Haak, R, Meijers-Heijboer, H, van Leeuwen, EM, Iyengar, SK, Lass, JH, Hofman, A, Rivadeneira, F, Uitterlinden, AG, Vingerling, JR, Lehtimäki, T, Raitakari, OT, Biino, G, Concas, MP, Schwantes-An, TH, Igo, RP Jr, Cuellar-Partida, G, Martin, NG, Craig, JE, Gharahkhani, P, Williams, KM, Nag, A, Rahi, JS, Cumberland, PM, Delcourt, C, Bellenguez, C, Ried, JS, Bergen, AA, Meitinger, T, Gieger, C, Wong, TY, Hewitt, AW, Mackey, DA, Simpson, CL, Pfeiffer, N, Pärssinen, O, Baird, PN, Vitart, V, Amin, N, van Duijn, CM, Bailey-Wilson, JE, Young, TL, Saw, SM, Stambolian, D, MacGregor, S, Guggenheim, JA, Tung, JY, Hammond, CJ, Klaver, CCW. Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nat. Genet. 2018; 50 (6): 834-848. PubMed PMID:29808027 PubMed Central PMC5980758.
  3. Khawaja, AP, Cooke Bailey, JN, Wareham, NJ, Scott, RA, Simcoe, M, Igo, RP Jr, Song, YE, Wojciechowski, R, Cheng, CY, Khaw, PT, Pasquale, LR, Haines, JL, Foster, PJ, Wiggs, JL, Hammond, CJ, Hysi, PG, UK Biobank Eye and Vision Consortium, NEIGHBORHOOD Consortium. Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nat. Genet. 2018; 50 (6): 778-782. PubMed PMID:29785010 PubMed Central PMC5985943.
  4. Nittala, MG, Song, YE, Sardell, R, Adams, LD, Pan, S, Velaga, SB, Horst, V, Dana, D, Caywood, L, Laux, R, Fuzzell, D, Fuzzell, S, Scott, WK, Cooke Bailey, JN, Igo, RP Jr, Haines, J, Pericak-Vance, MA, Sadda, SR, Stambolian, D. AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration. Retina (Philadelphia, Pa.) 2018; : . PubMed PMID:29746403 .
  5. van Zuydam, NR, Ahlqvist, E, Sandholm, N, Deshmukh, H, Rayner, NW, Abdalla, M, Ladenvall, C, Ziemek, D, Fauman, E, Robertson, NR, McKeigue, PM, Valo, E, Forsblom, C, Harjutsalo, V, Finnish Diabetic Nephropathy Study (FinnDiane), Perna, A, Rurali, E, Marcovecchio, ML, Igo, RP Jr, Salem, RM, Perico, N, Lajer, M, Käräjämäki, A, Imamura, M, Kubo, M, Takahashi, A, Sim, X, Liu, J, van Dam, RM, Jiang, G, Tam, CHT, Luk, AOY, Lee, HM, Lim, CKP, Szeto, CC, So, WY, Chan, JCN, Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Ang, SF, Dorajoo, R, Wang, L, Clara, TSH, McKnight, AJ, Duffy, S, Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Pezzolesi, MG, GENIE (GEnetics of Nephropathy an International Effort) Consortium, Marre, M, Gyorgy, B, Hadjadj, S, Hiraki, LT, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Ahluwalia, TS, Almgren, P, Schulz, CA, Orho-Melander, M, Linneberg, A, Christensen, C, Witte, DR, Grarup, N, Brandslund, I, Melander, O, Paterson, AD, Tregouet, D, Maxwell, AP, Lim, SC, Ma, RCW, Tai, ES, Maeda, S, Lyssenko, V, Tuomi, T, Krolewski, AS, Rich, SS, Hirschhorn, JN, Florez, JC, Dunger, D, Pedersen, O, Hansen, T, Rossing, P, Remuzzi, G, SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Brosnan, MJ, Palmer, CNA, Groop, PH, Colhoun, HM, Groop, LC, McCarthy, MI. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes 2018; 67 (7): 1414-1427. PubMed PMID:29703844 PubMed Central PMC6014557.
  6. Bailey, JNC, Gharahkhani, P, Kang, JH, Butkiewicz, M, Sullivan, DA, Weinreb, RN, Aschard, H, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP Jr, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Vollrath, D, Zack, DJ, Medeiros, F, Vajaranant, TS, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Craig, JE, Burdon, KP, Hewitt, AW, Mackey, DA, Haines, JL, MacGregor, S, Wiggs, JL, Pasquale, LR, Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium. Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets. Invest. Ophthalmol. Vis. Sci. 2018; 59 (2): 629-636. PubMed PMID:29392307 PubMed Central PMC5795896.
  7. Aschard, H, Kang, JH, Iglesias, AI, Hysi, P, Cooke Bailey, JN, Khawaja, AP, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP Jr, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Haven, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Cheng, CY, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, International Glaucoma Genetics Consortium, Klaver, CCW, vanDuijn, CM, Haines, J, Wiggs, JL, Pasquale, LR. Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis. Eur. J. Hum. Genet. 2017; 25 (11): 1261-1267. PubMed PMID:28853718 PubMed Central PMC5643970.
  8. Sobota, RS, Stein, CM, Kodaman, N, Maro, I, Wieland-Alter, W, Igo, RP Jr, Magohe, A, Malone, LL, Chervenak, K, Hall, NB, Matee, M, Mayanja-Kizza, H, Joloba, M, Moore, JH, Scott, WK, Lahey, T, Boom, WH, von Reyn, CF, Williams, SM, Sirugo, G. A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa. PLoS Genet. 2017; 13 (6): e1006710. PubMed PMID:28628665 PubMed Central PMC5495514.
  9. Aung, T, Ozaki, M, Lee, MC, Schlötzer-Schrehardt, U, Thorleifsson, G, Mizoguchi, T, Igo, RP Jr, Haripriya, A, Williams, SE, Astakhov, YS, Orr, AC, Burdon, KP, Nakano, S, Mori, K, Abu-Amero, K, Hauser, M, Li, Z, Prakadeeswari, G, Bailey, JNC, Cherecheanu, AP, Kang, JH, Nelson, S, Hayashi, K, Manabe, SI, Kazama, S, Zarnowski, T, Inoue, K, Irkec, M, Coca-Prados, M, Sugiyama, K, Järvelä, I, Schlottmann, P, Lerner, SF, Lamari, H, Nilgün, Y, Bikbov, M, Park, KH, Cha, SC, Yamashiro, K, Zenteno, JC, Jonas, JB, Kumar, RS, Perera, SA, Chan, ASY, Kobakhidze, N, George, R, Vijaya, L, Do, T, Edward, DP, de Juan Marcos, L, Pakravan, M, Moghimi, S, Ideta, R, Bach-Holm, D, Kappelgaard, P, Wirostko, B, Thomas, S, Gaston, D, Bedard, K, Greer, WL, Yang, Z, Chen, X, Huang, L, Sang, J, Jia, H, Jia, L, Qiao, C, Zhang, H, Liu, X, Zhao, B, Wang, YX, Xu, L, Leruez, S, Reynier, P, Chichua, G, Tabagari, S, Uebe, S, Zenkel, M, Berner, D, Mossböck, G, Weisschuh, N, Hoja, U, Welge-Luessen, UC, Mardin, C, Founti, P, Chatzikyriakidou, A, Pappas, T, Anastasopoulos, E, Lambropoulos, A, Ghosh, A, Shetty, R, Porporato, N, Saravanan, V, Venkatesh, R, Shivkumar, C, Kalpana, N, Sarangapani, S, Kanavi, MR, Beni, AN, Yazdani, S, Lashay, A, Naderifar, H, Khatibi, N, Fea, A, Lavia, C, Dallorto, L, Rolle, T, Frezzotti, P, Paoli, D, Salvi, E, Manunta, P, Mori, Y, Miyata, K, Higashide, T, Chihara, E, Ishiko, S, Yoshida, A, Yanagi, M, Kiuchi, Y, Ohashi, T, Sakurai, T, Sugimoto, T, Chuman, H, Aihara, M, Inatani, M, Miyake, M, Gotoh, N, Matsuda, F, Yoshimura, N, Ikeda, Y, Ueno, M, Sotozono, C, Jeoung, JW, Sagong, M, Park, KH, Ahn, J, Cruz-Aguilar, M, Ezzouhairi, SM, Rafei, A, Chong, YF, Ng, XY, Goh, SR, Chen, Y, Yong, VHK, Khan, MI, Olawoye, OO, Ashaye, AO, Ugbede, I, Onakoya, A, Kizor-Akaraiwe, N, Teekhasaenee, C, Suwan, Y, Supakontanasan, W, Okeke, S, Uche, NJ, Asimadu, I, Ayub, H, Akhtar, F, Kosior-Jarecka, E, Lukasik, U, Lischinsky, I, Castro, V, Grossmann, RP, Sunaric Megevand, G, Roy, S, Dervan, E, Silke, E, Rao, A, Sahay, P, Fornero, P, Cuello, O, Sivori, D, Zompa, T, Mills, RA, Souzeau, E, Mitchell, P, Wang, JJ, Hewitt, AW, Coote, M, Crowston, JG, Astakhov, SY, Akopov, EL, Emelyanov, A, Vysochinskaya, V, Kazakbaeva, G, Fayzrakhmanov, R, Al-Obeidan, SA, Owaidhah, O, Aljasim, LA, Chowbay, B, Foo, JN, Soh, RQ, Sim, KS, Xie, Z, Cheong, AWO, Mok, SQ, Soo, HM, Chen, XY, Peh, SQ, Heng, KK, Husain, R, Ho, SL, Hillmer, AM, Cheng, CY, Escudero-Domínguez, FA, González-Sarmiento, R, Martinon-Torres, F, Salas, A, Pathanapitoon, K, Hansapinyo, L, Wanichwecharugruang, B, Kitnarong, N, Sakuntabhai, A, Nguyn, HX, Nguyn, GTT, Nguyn, TV, Zenz, W, Binder, A, Klobassa, DS, Hibberd, ML, Davila, S, Herms, S, Nöthen, MM, Moebus, S, Rautenbach, RM, Ziskind, A, Carmichael, TR, Ramsay, M, Álvarez, L, García, M, González-Iglesias, H, Rodríguez-Calvo, PP, Fernández-Vega Cueto, L, Oguz, Ç, Tamcelik, N, Atalay, E, Batu, B, Aktas, D, Kasım, B, Wilson, MR, Coleman, AL, Liu, Y, Challa, P, Herndon, L, Kuchtey, RW, Kuchtey, J, Curtin, K, Chaya, CJ, Crandall, A, Zangwill, LM, Wong, TY, Nakano, M, Kinoshita, S, den Hollander, AI, Vesti, E, Fingert, JH, Lee, RK, Sit, AJ, Shingleton, BJ, Wang, N, Cusi, D, Qamar, R, Kraft, P, Pericak-Vance, MA, Raychaudhuri, S, Heegaard, S, Kivelä, T, Reis, A, Kruse, FE, Weinreb, RN, Pasquale, LR, Haines, JL, Thorsteinsdottir, U, Jonasson, F, Allingham, RR, Milea, D, Ritch, R, Kubota, T, Tashiro, K, Vithana, EN, Micheal, S, Topouzis, F, Craig, JE, Dubina, M, Sundaresan, P, Stefansson, K, Wiggs, JL, Pasutto, F, Khor, CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat. Genet. 2017; 49 (7): 993-1004. PubMed PMID:28553957 .
  10. Afshari, NA, Igo, RP Jr, Morris, NJ, Stambolian, D, Sharma, S, Pulagam, VL, Dunn, S, Stamler, JF, Truitt, BJ, Rimmler, J, Kuot, A, Croasdale, CR, Qin, X, Burdon, KP, Riazuddin, SA, Mills, R, Klebe, S, Minear, MA, Zhao, J, Balajonda, E, Rosenwasser, GO, Baratz, KH, Mootha, VV, Patel, SV, Gregory, SG, Bailey-Wilson, JE, Price, MO, Price, FW Jr, Craig, JE, Fingert, JH, Gottsch, JD, Aldave, AJ, Klintworth, GK, Lass, JH, Li, YJ, Iyengar, SK. Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun 2017; 8 : 14898. PubMed PMID:28358029 PubMed Central PMC5379100.
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