Rob Igo_crop

Rob Igo, PhD

Assistant Professor

rpi@.case.edu | 216.368.4562 | Wolstein Research Bldg. Rm. 1302

Education

B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005

Research Interests

I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, age-related macular degeneration and susceptibility to tuberculosis.

Professional Memberships

American Society of Human Genetics
International Genetic Epidemiology Society

Courses Taught

EPBI 452: Statistical Methods for Genetic Epidemiology
EPBI 502: Genetic Epidemiology Seminar

Recent Publications

  1. Craig, JE, Han, X, Qassim, A, Hassall, M, Cooke Bailey, JN, Kinzy, TG, Khawaja, AP, An, J, Marshall, H, Gharahkhani, P, Igo, RP Jr, Graham, SL, Healey, PR, Ong, JS, Zhou, T, Siggs, O, Law, MH, Souzeau, E, Ridge, B, Hysi, PG, Burdon, KP, Mills, RA, Landers, J, Ruddle, JB, Agar, A, Galanopoulos, A, White, AJR, Willoughby, CE, Andrew, NH, Best, S, Vincent, AL, Goldberg, I, Radford-Smith, G, Martin, NG, Montgomery, GW, Vitart, V, Hoehn, R, Wojciechowski, R, Jonas, JB, Aung, T, Pasquale, LR, Cree, AJ, Sivaprasad, S, Vallabh, NA, NEIGHBORHOOD consortium, UK Biobank Eye and Vision Consortium, Viswanathan, AC, Pasutto, F, Haines, JL, Klaver, CCW, van Duijn, CM, Casson, RJ, Foster, PJ, Khaw, PT, Hammond, CJ, Mackey, DA, Mitchell, P, Lotery, AJ, Wiggs, JL, Hewitt, AW, MacGregor, S. Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nat. Genet. 2020; 52 (2): 160-166. PubMed PMID:31959993 .
  2. Zein, J, Gaston, B, Bazeley, P, DeBoer, MD, Igo, RP Jr, Bleecker, ER, Meyers, D, Comhair, S, Marozkina, NV, Cotton, C, Patel, M, Alyamani, M, Xu, W, Busse, WW, Calhoun, WJ, Ortega, V, Hawkins, GA, Castro, M, Chung, KF, Fahy, JV, Fitzpatrick, AM, Israel, E, Jarjour, NN, Levy, B, Mauger, DT, Moore, WC, Noel, P, Peters, SP, Teague, WG, Wenzel, SE, Erzurum, SC, Sharifi, N. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Proc. Natl. Acad. Sci. U.S.A. 2020; 117 (4): 2187-2193. PubMed PMID:31932420 PubMed Central PMC6995013.
  3. Igo, RP Jr, Kinzy, TG, Cooke Bailey, JN. Genetic Risk Scores. Curr Protoc Hum Genet 2019; 104 (1): e95. PubMed PMID:31765077 PubMed Central PMC6941594.
  4. Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser, MA, Allingham, RR, Aung, T, Van Der Heide, CJ, Taylor, KD, Rotter, JI, Wang, SJ, Bonnemaijer, PWM, Williams, SE, Abdullahi, SM, Abu-Amero, KK, Anderson, MG, Akafo, S, Alhassan, MB, Asimadu, I, Ayyagari, R, Bakayoko, S, Nyamsi, PB, Bowden, DW, Bromley, WC, Budenz, DL, Carmichael, TR, Challa, P, Chen, YI, Chuka-Okosa, CM, Cooke Bailey, JN, Costa, VP, Cruz, DA, DuBiner, H, Ervin, JF, Feldman, RM, Flamme-Wiese, M, Gaasterland, DE, Garnai, SJ, Girkin, CA, Guirou, N, Guo, X, Haines, JL, Hammond, CJ, Herndon, L, Hoffmann, TJ, Hulette, CM, Hydara, A, Igo, RP Jr, Jorgenson, E, Kabwe, J, Kilangalanga, NJ, Kizor-Akaraiwe, N, Kuchtey, RW, Lamari, H, Li, Z, Liebmann, JM, Liu, Y, Loos, RJF, Melo, MB, Moroi, SE, Msosa, JM, Mullins, RF, Nadkarni, G, Napo, A, Ng, MCY, Nunes, HF, Obeng-Nyarkoh, E, Okeke, A, Okeke, S, Olaniyi, O, Olawoye, O, Oliveira, MB, Pasquale, LR, Perez-Grossmann, RA, Pericak-Vance, MA, Qin, X, Ramsay, M, Resnikoff, S, Richards, JE, Schimiti, RB, Sim, KS, Sponsel, WE, Svidnicki, PV, Thiadens, AAHJ, Uche, NJ, van Duijn, CM, de Vasconcellos, JPC, Wiggs, JL, Zangwill, LM, Risch, N, Milea, D, Ashaye, A, Klaver, CCW, Weinreb, RN, Ashley Koch, AE, Fingert, JH, Khor, CC. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. JAMA 2019; 322 (17): 1682-1691. PubMed PMID:31688885 PubMed Central PMC6865235.
  5. Lewis, BA, Freebairn, L, Tag, J, Igo, RP Jr, Ciesla, A, Iyengar, SK, Stein, CM, Taylor, HG. Differential Long-Term Outcomes for Individuals With Histories of Preschool Speech Sound Disorders. Am J Speech Lang Pathol 2019; 28 (4): 1582-1596. PubMed PMID:31604025 .
  6. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN, International Age-Related Macular Degeneration Genomics Consortium. Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2019; 60 (12): 4041-4051. PubMed PMID:31560769 PubMed Central PMC6779289.
  7. Fan, BJ, Bailey, JC, Igo, RP Jr, Kang, JH, Boumenna, T, Brilliant, MH, Budenz, DL, Fingert, JH, Gaasterland, T, Gaasterland, D, Hauser, MA, Kraft, P, Lee, RK, Lichter, PR, Liu, Y, Moroi, SE, Myers, JS, Pericak-Vance, MA, Realini, A, Rhee, DJ, Richards, JE, Ritch, R, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Vollrath, D, Weinreb, RN, Wollstein, G, Zack, DJ, Haines, JL, Pasquale, LR, Wiggs, JL. Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis. JAMA Ophthalmol 2019; : . PubMed PMID:31436842 PubMed Central PMC6707005.
  8. Waksmunski, AR, Igo, RP Jr, Song, YE, Cooke Bailey, JN, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M, Stambolian, D, Scott, WK, Pericak-Vance, MA, Haines, JL. Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. Hum. Genet. 2019; 138 (10): 1171-1182. PubMed PMID:31367973 PubMed Central PMC6745026.
  9. Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC, Crawford, DC, VA Million Veteran Program. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
  10. Laville, V, Kang, JH, Cousins, CC, Iglesias, AI, Nagy, R, Cooke Bailey, JN, Igo, RP Jr, Song, YE, Chasman, DI, Christen, WG, Kraft, P, Rosner, BA, Hu, F, Wilson, JF, Gharahkhani, P, Hewitt, AW, Mackey, DA, Hysi, PG, Hammond, CJ, vanDuijn, CM, Haines, JL, Vitart, V, Fingert, JH, Hauser, MA, Aschard, H, Wiggs, JL, Khawaja, AP, MacGregor, S, Pasquale, LR, UK Biobank, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium. Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes. Am. J. Ophthalmol. 2019; 206 : 245-255. PubMed PMID:31121135 PubMed Central PMC6864262.
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