Rob Igo_crop

Rob Igo, PhD

Assistant Professor

rpi@.case.edu | 216.368.4562 | Wolstein Research Bldg. Rm. 1302

Education

B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005

Research Interests

I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, age-related macular degeneration and susceptibility to tuberculosis.

Professional Memberships

American Society of Human Genetics
International Genetic Epidemiology Society

Courses Taught

EPBI 452: Statistical Methods for Genetic Epidemiology
EPBI 502: Genetic Epidemiology Seminar

Recent Publications

  1. Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser, MA, Allingham, RR, Aung, T, Van Der Heide, CJ, Taylor, KD, Rotter, JI, Wang, SJ, Bonnemaijer, PWM, Williams, SE, Abdullahi, SM, Abu-Amero, KK, Anderson, MG, Akafo, S, Alhassan, MB, Asimadu, I, Ayyagari, R, Bakayoko, S, Nyamsi, PB, Bowden, DW, Bromley, WC, Budenz, DL, Carmichael, TR, Challa, P, Chen, YI, Chuka-Okosa, CM, Cooke Bailey, JN, Costa, VP, Cruz, DA, DuBiner, H, Ervin, JF, Feldman, RM, Flamme-Wiese, M, Gaasterland, DE, Garnai, SJ, Girkin, CA, Guirou, N, Guo, X, Haines, JL, Hammond, CJ, Herndon, L, Hoffmann, TJ, Hulette, CM, Hydara, A, Igo, RP Jr, Jorgenson, E, Kabwe, J, Kilangalanga, NJ, Kizor-Akaraiwe, N, Kuchtey, RW, Lamari, H, Li, Z, Liebmann, JM, Liu, Y, Loos, RJF, Melo, MB, Moroi, SE, Msosa, JM, Mullins, RF, Nadkarni, G, Napo, A, Ng, MCY, Nunes, HF, Obeng-Nyarkoh, E, Okeke, A, Okeke, S, Olaniyi, O, Olawoye, O, Oliveira, MB, Pasquale, LR, Perez-Grossmann, RA, Pericak-Vance, MA, Qin, X, Ramsay, M, Resnikoff, S, Richards, JE, Schimiti, RB, Sim, KS, Sponsel, WE, Svidnicki, PV, Thiadens, AAHJ, Uche, NJ, van Duijn, CM, de Vasconcellos, JPC, Wiggs, JL, Zangwill, LM, Risch, N, Milea, D, Ashaye, A, Klaver, CCW, Weinreb, RN, Ashley Koch, AE, Fingert, JH, Khor, CC. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. JAMA 2019; 322 (17): 1682-1691. PubMed PMID:31688885 .
  2. Lewis, BA, Freebairn, L, Tag, J, Igo, RP Jr, Ciesla, A, Iyengar, SK, Stein, CM, Taylor, HG. Differential Long-Term Outcomes for Individuals With Histories of Preschool Speech Sound Disorders. Am J Speech Lang Pathol 2019; : 1-15. PubMed PMID:31604025 .
  3. Waksmunski, AR, Grunin, M, Kinzy, TG, Igo, RP Jr, Haines, JL, Cooke Bailey, JN, International Age-Related Macular Degeneration Genomics Consortium. Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2019; 60 (12): 4041-4051. PubMed PMID:31560769 PubMed Central PMC6779289.
  4. Fan, BJ, Bailey, JC, Igo, RP Jr, Kang, JH, Boumenna, T, Brilliant, MH, Budenz, DL, Fingert, JH, Gaasterland, T, Gaasterland, D, Hauser, MA, Kraft, P, Lee, RK, Lichter, PR, Liu, Y, Moroi, SE, Myers, JS, Pericak-Vance, MA, Realini, A, Rhee, DJ, Richards, JE, Ritch, R, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Vollrath, D, Weinreb, RN, Wollstein, G, Zack, DJ, Haines, JL, Pasquale, LR, Wiggs, JL. Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis. JAMA Ophthalmol 2019; : . PubMed PMID:31436842 PubMed Central PMC6707005.
  5. Waksmunski, AR, Igo, RP Jr, Song, YE, Cooke Bailey, JN, Laux, R, Fuzzell, D, Fuzzell, S, Adams, LD, Caywood, L, Prough, M, Stambolian, D, Scott, WK, Pericak-Vance, MA, Haines, JL. Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. Hum. Genet. 2019; 138 (10): 1171-1182. PubMed PMID:31367973 PubMed Central PMC6745026.
  6. Halladay, CW, Hadi, T, Anger, MD, Greenberg, PB, Sullivan, JM, Konicki, PE, Peachey, NS, Igo, RP Jr, Iyengar, SK, Wu, WC, Crawford, DC, VA Million Veteran Program. Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. AMIA Jt Summits Transl Sci Proc 2019; 2019 : 153-162. PubMed PMID:31258967 PubMed Central PMC6568141.
  7. Laville, V, Kang, JH, Cousins, CC, Iglesias, AI, Nagy, R, Cooke Bailey, JN, Igo, RP Jr, Song, YE, Chasman, DI, Christen, WG, Kraft, P, Rosner, BA, Hu, F, Wilson, JF, Gharahkhani, P, Hewitt, AW, Mackey, DA, Hysi, PG, Hammond, CJ, vanDuijn, CM, Haines, JL, Vitart, V, Fingert, JH, Hauser, MA, Aschard, H, Wiggs, JL, Khawaja, AP, MacGregor, S, Pasquale, LR, UK Biobank, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium. Genetic correlations between diabetes and glaucoma: an analysis of continuous and dichotomous phenotypes. Am. J. Ophthalmol. 2019; : . PubMed PMID:31121135 .
  8. Alward, WLM, van der Heide, C, Khanna, CL, Roos, BR, Sivaprasad, S, Kam, J, Ritch, R, Lotery, A, Igo, RP Jr, Cooke Bailey, JN, Stone, EM, Scheetz, TE, Kwon, YH, Pasquale, LR, Wiggs, JL, Fingert, JH, NEIGHBORHOOD Consortium. Myocilin Mutations in Patients With Normal-Tension Glaucoma. JAMA Ophthalmol 2019; 137 (5): 559-563. PubMed PMID:30816940 PubMed Central PMC6512256.
  9. Pollack, S, Igo, RP Jr, Jensen, RA, Christiansen, M, Li, X, Cheng, CY, Ng, MCY, Smith, AV, Rossin, EJ, Segrè, AV, Davoudi, S, Tan, GS, Chen, YI, Kuo, JZ, Dimitrov, LM, Stanwyck, LK, Meng, W, Hosseini, SM, Imamura, M, Nousome, D, Kim, J, Hai, Y, Jia, Y, Ahn, J, Leong, A, Shah, K, Park, KH, Guo, X, Ipp, E, Taylor, KD, Adler, SG, Sedor, JR, Freedman, BI, Family Investigation of Nephropathy and Diabetes-Eye Research Group, DCCT/EDIC Research Group, Lee, IT, Sheu, WH, Kubo, M, Takahashi, A, Hadjadj, S, Marre, M, Tregouet, DA, Mckean-Cowdin, R, Varma, R, McCarthy, MI, Groop, L, Ahlqvist, E, Lyssenko, V, Agardh, E, Morris, A, Doney, ASF, Colhoun, HM, Toppila, I, Sandholm, N, Groop, PH, Maeda, S, Hanis, CL, Penman, A, Chen, CJ, Hancock, H, Mitchell, P, Craig, JE, Chew, EY, Paterson, AD, Grassi, MA, Palmer, C, Bowden, DW, Yaspan, BL, Siscovick, D, Cotch, MF, Wang, JJ, Burdon, KP, Wong, TY, Klein, BEK, Klein, R, Rotter, JI, Iyengar, SK, Price, AL, Sobrin, L. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019; 68 (2): 441-456. PubMed PMID:30487263 PubMed Central PMC6341299.
  10. Igo, RP Jr, Hall, NB, Malone, LL, Hall, JB, Truitt, B, Qiu, F, Tao, L, Mupere, E, Schnell, A, Hawn, TR, Bush, WS, Joloba, M, Boom, WH, Stein, CM. Fine-mapping analysis of a chromosome 2 region linked to resistance to Mycobacterium tuberculosis infection in Uganda reveals potential regulatory variants. Genes Immun. 2019; 20 (6): 473-483. PubMed PMID:30100616 PubMed Central PMC6374218.
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