Rob Igo_crop

Rob Igo, PhD

Assistant Professor

rpi@.case.edu | 216.368.4562 | Wolstein Research Bldg. Rm. 1302

Education

B.A. in Mathematics, Oberlin College, 1988
Ph.D. in Anatomy (Molecular Biology), University of Utah, 1997
M.S. in Biostatistics, University of Washington, 2005

Research Interests

I am interested in developing and applying statistical methods to identify genetic factors influencing complex traits. I participate in collaborative research projects focused on Fuchs endothelial corneal dystrophy, kidney disease in diabetes, age-related macular degeneration and susceptibility to tuberculosis.

Professional Memberships

American Society of Human Genetics
International Genetic Epidemiology Society

Courses Taught

EPBI 452: Statistical Methods for Genetic Epidemiology
EPBI 502: Genetic Epidemiology Seminar

Recent Publications

  1. Aschard, H, Kang, JH, Iglesias, AI, Hysi, P, Cooke Bailey, JN, Khawaja, AP, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, JH, Budenz, DL, Realini, T, Gaasterland, T, Scott, WK, Singh, K, Sit, AJ, Igo, RP Jr, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Haven, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Cheng, CY, Chasman, DI, Christen, WG, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, International Glaucoma Genetics Consortium, Klaver, CCW, vanDuijn, CM, Haines, J, Wiggs, JL, Pasquale, LR. Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis. Eur. J. Hum. Genet. 2017; : . PubMed PMID:28853718 .
  2. Sobota, RS, Stein, CM, Kodaman, N, Maro, I, Wieland-Alter, W, Igo, RP Jr, Magohe, A, Malone, LL, Chervenak, K, Hall, NB, Matee, M, Mayanja-Kizza, H, Joloba, M, Moore, JH, Scott, WK, Lahey, T, Boom, WH, von Reyn, CF, Williams, SM, Sirugo, G. A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa. PLoS Genet. 2017; 13 (6): e1006710. PubMed PMID:28628665 PubMed Central PMC5495514.
  3. Aung, T, Ozaki, M, Lee, MC, Schlötzer-Schrehardt, U, Thorleifsson, G, Mizoguchi, T, Igo, RP Jr, Haripriya, A, Williams, SE, Astakhov, YS, Orr, AC, Burdon, KP, Nakano, S, Mori, K, Abu-Amero, K, Hauser, M, Li, Z, Prakadeeswari, G, Bailey, JNC, Cherecheanu, AP, Kang, JH, Nelson, S, Hayashi, K, Manabe, SI, Kazama, S, Zarnowski, T, Inoue, K, Irkec, M, Coca-Prados, M, Sugiyama, K, Järvelä, I, Schlottmann, P, Lerner, SF, Lamari, H, Nilgün, Y, Bikbov, M, Park, KH, Cha, SC, Yamashiro, K, Zenteno, JC, Jonas, JB, Kumar, RS, Perera, SA, Chan, ASY, Kobakhidze, N, George, R, Vijaya, L, Do, T, Edward, DP, de Juan Marcos, L, Pakravan, M, Moghimi, S, Ideta, R, Bach-Holm, D, Kappelgaard, P, Wirostko, B, Thomas, S, Gaston, D, Bedard, K, Greer, WL, Yang, Z, Chen, X, Huang, L, Sang, J, Jia, H, Jia, L, Qiao, C, Zhang, H, Liu, X, Zhao, B, Wang, YX, Xu, L, Leruez, S, Reynier, P, Chichua, G, Tabagari, S, Uebe, S, Zenkel, M, Berner, D, Mossböck, G, Weisschuh, N, Hoja, U, Welge-Luessen, UC, Mardin, C, Founti, P, Chatzikyriakidou, A, Pappas, T, Anastasopoulos, E, Lambropoulos, A, Ghosh, A, Shetty, R, Porporato, N, Saravanan, V, Venkatesh, R, Shivkumar, C, Kalpana, N, Sarangapani, S, Kanavi, MR, Beni, AN, Yazdani, S, Lashay, A, Naderifar, H, Khatibi, N, Fea, A, Lavia, C, Dallorto, L, Rolle, T, Frezzotti, P, Paoli, D, Salvi, E, Manunta, P, Mori, Y, Miyata, K, Higashide, T, Chihara, E, Ishiko, S, Yoshida, A, Yanagi, M, Kiuchi, Y, Ohashi, T, Sakurai, T, Sugimoto, T, Chuman, H, Aihara, M, Inatani, M, Miyake, M, Gotoh, N, Matsuda, F, Yoshimura, N, Ikeda, Y, Ueno, M, Sotozono, C, Jeoung, JW, Sagong, M, Park, KH, Ahn, J, Cruz-Aguilar, M, Ezzouhairi, SM, Rafei, A, Chong, YF, Ng, XY, Goh, SR, Chen, Y, Yong, VHK, Khan, MI, Olawoye, OO, Ashaye, AO, Ugbede, I, Onakoya, A, Kizor-Akaraiwe, N, Teekhasaenee, C, Suwan, Y, Supakontanasan, W, Okeke, S, Uche, NJ, Asimadu, I, Ayub, H, Akhtar, F, Kosior-Jarecka, E, Lukasik, U, Lischinsky, I, Castro, V, Grossmann, RP, Megevand, GS, Roy, S, Dervan, E, Silke, E, Rao, A, Sahay, P, Fornero, P, Cuello, O, Sivori, D, Zompa, T, Mills, RA, Souzeau, E, Mitchell, P, Wang, JJ, Hewitt, AW, Coote, M, Crowston, JG, Astakhov, SY, Akopov, EL, Emelyanov, A, Vysochinskaya, V, Kazakbaeva, G, Fayzrakhmanov, R, Al-Obeidan, SA, Owaidhah, O, Aljasim, LA, Chowbay, B, Foo, JN, Soh, RQ, Sim, KS, Xie, Z, Cheong, AWO, Mok, SQ, Soo, HM, Chen, XY, Peh, SQ, Heng, KK, Husain, R, Ho, SL, Hillmer, AM, Cheng, CY, Escudero-Domínguez, FA, González-Sarmiento, R, Martinon-Torres, F, Salas, A, Pathanapitoon, K, Hansapinyo, L, Wanichwecharugruang, B, Kitnarong, N, Sakuntabhai, A, Nguyn, HX, Nguyn, GTT, Nguyn, TV, Zenz, W, Binder, A, Klobassa, DS, Hibberd, ML, Davila, S, Herms, S, Nöthen, MM, Moebus, S, Rautenbach, RM, Ziskind, A, Carmichael, TR, Ramsay, M, Álvarez, L, García, M, González-Iglesias, H, Rodríguez-Calvo, PP, Cueto, LF, Oguz, Ç, Tamcelik, N, Atalay, E, Batu, B, Aktas, D, Kasım, B, Wilson, MR, Coleman, AL, Liu, Y, Challa, P, Herndon, L, Kuchtey, RW, Kuchtey, J, Curtin, K, Chaya, CJ, Crandall, A, Zangwill, LM, Wong, TY, Nakano, M, Kinoshita, S, den Hollander, AI, Vesti, E, Fingert, JH, Lee, RK, Sit, AJ, Shingleton, BJ, Wang, N, Cusi, D, Qamar, R, Kraft, P, Pericak-Vance, MA, Raychaudhuri, S, Heegaard, S, Kivelä, T, Reis, A, Kruse, FE, Weinreb, RN, Pasquale, LR, Haines, JL, Thorsteinsdottir, U, Jonasson, F, Allingham, RR, Milea, D, Ritch, R, Kubota, T, Tashiro, K, Vithana, EN, Micheal, S, Topouzis, F, Craig, JE, Dubina, M, Sundaresan, P, Stefansson, K, Wiggs, JL, Pasutto, F, Khor, CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nat. Genet. 2017; 49 (7): 993-1004. PubMed PMID:28553957 .
  4. Afshari, NA, Igo, RP Jr, Morris, NJ, Stambolian, D, Sharma, S, Pulagam, VL, Dunn, S, Stamler, JF, Truitt, BJ, Rimmler, J, Kuot, A, Croasdale, CR, Qin, X, Burdon, KP, Riazuddin, SA, Mills, R, Klebe, S, Minear, MA, Zhao, J, Balajonda, E, Rosenwasser, GO, Baratz, KH, Mootha, VV, Patel, SV, Gregory, SG, Bailey-Wilson, JE, Price, MO, Price, FW Jr, Craig, JE, Fingert, JH, Gottsch, JD, Aldave, AJ, Klintworth, GK, Lass, JH, Li, YJ, Iyengar, SK. Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun 2017; 8 : 14898. PubMed PMID:28358029 PubMed Central PMC5379100.
  5. Pasquale, LR, Aschard, H, Kang, JH, Bailey, JN, Lindström, S, Chasman, DI, Christen, WG, Allingham, RR, Ashley-Koch, A, Lee, RK, Moroi, SE, Brilliant, MH, Wollstein, G, Schuman, JS, Fingert, J, Budenz, DL, Realini, T, Gaasterland, T, Gaasterland, D, Scott, WK, Singh, K, Sit, AJ, Igo, RP Jr, Song, YE, Hark, L, Ritch, R, Rhee, DJ, Gulati, V, Havens, S, Vollrath, D, Zack, DJ, Medeiros, F, Weinreb, RN, Pericak-Vance, MA, Liu, Y, Kraft, P, Richards, JE, Rosner, BA, Hauser, MA, Haines, JL, Wiggs, JL. Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample. Menopause 2017; 24 (2): 150-156. PubMed PMID:27760082 PubMed Central PMC5266624.
  6. Cooke Bailey, JN, Igo, RP Jr. Genetic Risk Scores. Curr Protoc Hum Genet 2016; 91 : 1.29.1-1.29.9. PubMed PMID:27727440 .
  7. Liu, Y, Bailey, JC, Helwa, I, Dismuke, WM, Cai, J, Drewry, M, Brilliant, MH, Budenz, DL, Christen, WG, Chasman, DI, Fingert, JH, Gaasterland, D, Gaasterland, T, Gordon, MO, Igo, RP Jr, Kang, JH, Kass, MA, Kraft, P, Lee, RK, Lichter, P, Moroi, SE, Realini, A, Richards, JE, Ritch, R, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Song, YE, Vollrath, D, Weinreb, R, Medeiros, F, Wollstein, G, Zack, DJ, Zhang, K, Pericak-Vance, MA, Gonzalez, P, Stamer, WD, Kuchtey, J, Kuchtey, RW, Allingham, RR, Hauser, MA, Pasquale, LR, Haines, JL, Wiggs, JL. A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. Invest. Ophthalmol. Vis. Sci. 2016; 57 (10): 3974-81. PubMed PMID:27537254 PubMed Central PMC4991020.
  8. Igo, RP Jr, Cooke Bailey, JN, Romm, J, Haines, JL, Wiggs, JL. Quality Control for the Illumina HumanExome BeadChip. Curr Protoc Hum Genet 2016; 90 : 2.14.1-2.14.16. PubMed PMID:27367164 PubMed Central PMC5100670.
  9. Williams, RC, Elston, RC, Kumar, P, Knowler, WC, Abboud, HE, Adler, S, Bowden, DW, Divers, J, Freedman, BI, Igo, RP Jr, Ipp, E, Iyengar, SK, Kimmel, PL, Klag, MJ, Kohn, O, Langefeld, CD, Leehey, DJ, Nelson, RG, Nicholas, SB, Pahl, MV, Parekh, RS, Rotter, JI, Schelling, JR, Sedor, JR, Shah, VO, Smith, MW, Taylor, KD, Thameem, F, Thornley-Brown, D, Winkler, CA, Guo, X, Zager, P, Hanson, RL, FIND Research Group. Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). BMC Genomics 2016; 17 : 325. PubMed PMID:27142425 PubMed Central PMC4855449.
  10. Fan, Q, Verhoeven, VJ, Wojciechowski, R, Barathi, VA, Hysi, PG, Guggenheim, JA, Höhn, R, Vitart, V, Khawaja, AP, Yamashiro, K, Hosseini, SM, Lehtimäki, T, Lu, Y, Haller, T, Xie, J, Delcourt, C, Pirastu, M, Wedenoja, J, Gharahkhani, P, Venturini, C, Miyake, M, Hewitt, AW, Guo, X, Mazur, J, Huffman, JE, Williams, KM, Polasek, O, Campbell, H, Rudan, I, Vatavuk, Z, Wilson, JF, Joshi, PK, McMahon, G, St Pourcain, B, Evans, DM, Simpson, CL, Schwantes-An, TH, Igo, RP, Mirshahi, A, Cougnard-Gregoire, A, Bellenguez, C, Blettner, M, Raitakari, O, Kähönen, M, Seppala, I, Zeller, T, Meitinger, T, Consortium for Refractive Error and Myopia, Ried, JS, Gieger, C, Portas, L, van Leeuwen, EM, Amin, N, Uitterlinden, AG, Rivadeneira, F, Hofman, A, Vingerling, JR, Wang, YX, Wang, X, Tai-Hui Boh, E, Ikram, MK, Sabanayagam, C, Gupta, P, Tan, V, Zhou, L, Ho, CE, Lim, W, Beuerman, RW, Siantar, R, Tai, ES, Vithana, E, Mihailov, E, Khor, CC, Hayward, C, Luben, RN, Foster, PJ, Klein, BE, Klein, R, Wong, HS, Mitchell, P, Metspalu, A, Aung, T, Young, TL, He, M, Pärssinen, O, van Duijn, CM, Jin Wang, J, Williams, C, Jonas, JB, Teo, YY, Mackey, DA, Oexle, K, Yoshimura, N, Paterson, AD, Pfeiffer, N, Wong, TY, Baird, PN, Stambolian, D, Wilson, JE, Cheng, CY, Hammond, CJ, Klaver, CC, Saw, SM, Rahi, JS, Korobelnik, JF, Kemp, JP, Timpson, NJ, Smith, GD, Craig, JE, Burdon, KP, Fogarty, RD, Iyengar, SK, Chew, E, Janmahasatian, S, Martin, NG, MacGregor, S, Xu, L, Schache, M, Nangia, V, Panda-Jonas, S, Wright, AF, Fondran, JR, Lass, JH, Feng, S, Zhao, JH, Khaw, KT, Wareham, NJ, Rantanen, T, Kaprio, J, Pang, CP, Chen, LJ, Tam, PO, Jhanji, V, Young, AL, Döring, A, Raffel, LJ, Cotch, MF, Li, X, Yip, SP, Yap, MK, Biino, G, Vaccargiu, S, Fossarello, M, Fleck, B, Yazar, S, Tideman, JW, Tedja, M, Deangelis, MM, Morrison, M, Farrer, L, Zhou, X, Chen, W, Mizuki, N, Meguro, A, Mäkelä, KM. Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat Commun 2016; 7 : 11008. PubMed PMID:27020472 PubMed Central PMC4820539.
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