Scott M. Williams, PhD


Director, Epidemiology & Biostatistics Graduate Studies Program | 216.368.5659 | Wood Bldg. WG-82A


Ph.D. Washington University, St. Louis, 1981

BA, University of Chicago, 1976


2012 Fellow, American Association for the Advancement of Science

Professional Service

Section Editor, Natural Variation, PLoS Genetics, 2011-present
Section Editor, Genomics, Current Genetic Medicine Reports, 2012-present
Member Executive Committee, African Society of Human Genetics, 2013-present
Program Committee, Pacific Symposium on Biocomputing: Precision Medicine 2016

Research Interests

Scott M. Williams, PhD, is a professor and director of the Epidemiology & Biostatistics graduate studies program in the Department of Population and Quantitative Health Sciences. He also is a professor with the Department of Genetics and Genome Sciences. Both departments are part of Case Western Reserve University School of Medicine.

Williams is an expert in the genetics of complex human disease, including the genetic risk of adverse pregnancy outcomes, hypertension, cardiovascular disease, cancers, and susceptibility to infection. An experienced population geneticist, he studies how genes, either singly or in interactions with the environment, affect disease risk in different populations.

He has also been actively involved in developing statistical analyses for genetic susceptibility to disease, including colorectal and gastric cancers. He has studied the role of genetic factors for multiple infectious diseases, including malaria and tuberculosis. His work on TB has focused on resistance to TB in HIV positive individuals. Dr. Williams also has assessed the role of environmental changes in cardiovascular risk factors in West African populations.

Williams has extensive experience in graduate education, having developed the PhD program in human genetics at Vanderbilt University and served as program director of other institutions’ PhD programs.

Williams received his PhD in biology from Washington University, St. Louis, in 1981 and his BA in political science from the University of Chicago in 1976. Before coming to Case Western Reserve University, he was a professor in the Department of Genetics, Geisel School of Medicine, Dartmouth College, where he served as founding director of the Center for Integrative Biomedical Sciences and associate director of the Institute for Quantitative Biomedical Sciences.

Williams currently serves as an editor of PLoS Genetics and Current Genetic Medical Reports, and is a member of the executive committee of the African Society of Human Genetics.

He has published more than 250 papers addressing issues of disease risk, disparity, genetic differentiation, and methods to address these from both theoretical and practical perspectives.

Recent Publications

  1. Moore, JH, Mackay, TFC, Williams, SM. Testing the assumptions of parametric linear models: the need for biological data mining in disciplines such as human genetics. BioData Min 2019; 12 : 6. PubMed PMID:30792817 PubMed Central PMC6371539.
  2. Tavera, G, Morgan, DR, Williams, SM. Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch? Curr Genet Med Rep 2018; 6 (4): 199-207. PubMed PMID:30775159 PubMed Central PMC6373874.
  3. Menon, R, Williams, SM, Lamont, RF. Research to achieve a reduction in the global rate of preterm birth needs attention: Preface to the special issue by the preterm Birth International Collaborative (PREBIC). Placenta 2019; : . PubMed PMID:30658853 .
  4. Amosco, MD, Tavera, GR, Villar, VAM, Naniong, JMA, David-Bustamante, LMG, Williams, SM, Jose, PA, Palmes-Saloma, CP. Non-additive effects of ACVR2A in preeclampsia in a Philippine population. BMC Pregnancy Childbirth 2019; 19 (1): 11. PubMed PMID:30621627 PubMed Central PMC6323705.
  5. Copenhaver, GP, Weir, B, Rothstein, M, Tang, H, Williams, SM, Barsh, GS. Doubling down on forensic twin studies. PLoS Genet. 2018; 14 (12): e1007831. PubMed PMID:30571773 PubMed Central PMC6301560.
  6. Sausville, LN, Williams, SM, Pozzi, A. Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective. Pharmacol. Ther. 2018; : . PubMed PMID:30521883 .
  7. Sausville, LN, Gangadhariah, MH, Chiusa, M, Mei, S, Wei, S, Zent, R, Luther, JM, Shuey, MM, Capdevila, JH, Falck, JR, Guengerich, FP, Williams, SM, Pozzi, A. The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production. Cancer Res. 2018; 78 (17): 4865-4877. PubMed PMID:30012669 PubMed Central PMC6125168.
  8. Huusko, JM, Karjalainen, MK, Graham, BE, Zhang, G, Farrow, EG, Miller, NA, Jacobsson, B, Eidem, HR, Murray, JC, Bedell, B, Breheny, P, Brown, NW, Bødker, FL, Litterman, NK, Jiang, PP, Russell, L, Hinds, DA, Hu, Y, 23andMe Research Team, Rokas, A, Teramo, K, Christensen, K, Williams, SM, Rämet, M, Kingsmore, SF, Ryckman, KK, Hallman, M, Muglia, LJ. Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth. PLoS Genet. 2018; 14 (7): e1007394. PubMed PMID:30001343 PubMed Central PMC6042692.
  9. Ndiaye Diallo, R, Gadji, M, Hennig, BJ, Guèye, MV, Gaye, A, Diop, JPD, Sylla Niang, M, Lopez Sall, P, Guèye, PM, Dem, A, Faye, O, Dieye, A, Cisse, A, Sembene, M, Ka, S, Diop, N, Williams, SM, Matovu, E, Ramesar, RS, Wonkam, A, Newport, M, Rotimi, C, Ramsay, M. Strengthening human genetics research in Africa: report of the 9th meeting of the African Society of Human Genetics in Dakar in May 2016. Glob Health Epidemiol Genom 2017; 2 : e10. PubMed PMID:29868221 PubMed Central PMC5870411.
  10. Stein, CM, Sausville, L, Wejse, C, Sobota, RS, Zetola, NM, Hill, PC, Boom, WH, Scott, WK, Sirugo, G, Williams, SM. Genomics of human pulmonary tuberculosis: from genes to pathways. Curr Genet Med Rep 2017; 5 (4): 149-166. PubMed PMID:29805915 PubMed Central PMC5965286.
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