Scott M. Williams, PhD

Professor

smw154@case.edu | 216.368.5659 | Wood Bldg. WG-82A

Education

Ph.D. Washington University, St. Louis, 1981

Honors

2012 Fellow, American Association for the Advancement of Science

Professional Service

Section Editor, Natural Variation, PLoS Genetics, 2011-present
Section Editor, Genomics, Current Genetic Medicine Reports, 2012-present
Member Executive Committee, African Society of Human Genetics, 2013-present
Program Committee, Pacific Symposium on Biocomputing: Precision Medicine 2016

Recent Publications

  1. Sausville, LN, Gangadhariah, M, Chiusa, M, Mei, S, Wei, S, Zent, R, Luther, JM, Shuey, MM, Capdevila, JH, Falck, JR, Guengerich, FP, Williams, SM, Pozzi, A. The cytochrome P450 slow metabolizers CYP2C9*2 and CYP2C9*3 directly regulate tumorigenesis via reduced epoxyeicosatrienoic acid production. Cancer Res. 2018; : . PubMed PMID:30012669 .
  2. Huusko, JM, Karjalainen, MK, Graham, BE, Zhang, G, Farrow, EG, Miller, NA, Jacobsson, B, Eidem, HR, Murray, JC, Bedell, B, Breheny, P, Brown, NW, Bødker, FL, Litterman, NK, Jiang, PP, Russell, L, Hinds, DA, Hu, Y, 23andMe Research Team, Rokas, A, Teramo, K, Christensen, K, Williams, SM, Rämet, M, Kingsmore, SF, Ryckman, KK, Hallman, M, Muglia, LJ. Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth. PLoS Genet. 2018; 14 (7): e1007394. PubMed PMID:30001343 PubMed Central PMC6042692.
  3. Ndiaye Diallo, R, Gadji, M, Hennig, BJ, Guèye, MV, Gaye, A, Diop, JPD, Sylla Niang, M, Lopez Sall, P, Guèye, PM, Dem, A, Faye, O, Dieye, A, Cisse, A, Sembene, M, Ka, S, Diop, N, Williams, SM, Matovu, E, Ramesar, RS, Wonkam, A, Newport, M, Rotimi, C, Ramsay, M. Strengthening human genetics research in Africa: report of the 9th meeting of the African Society of Human Genetics in Dakar in May 2016. Glob Health Epidemiol Genom 2017; 2 : e10. PubMed PMID:29868221 PubMed Central PMC5870411.
  4. Stein, CM, Sausville, L, Wejse, C, Sobota, RS, Zetola, NM, Hill, PC, Boom, WH, Scott, WK, Sirugo, G, Williams, SM. Genomics of human pulmonary tuberculosis: from genes to pathways. Curr Genet Med Rep 2017; 5 (4): 149-166. PubMed PMID:29805915 PubMed Central PMC5965286.
  5. Manduchi, E, Williams, SM, Chesi, A, Johnson, ME, Wells, AD, Grant, SFA, Moore, JH. Leveraging epigenomics and contactomics data to investigate SNP pairs in GWAS. Hum. Genet. 2018; 137 (5): 413-425. PubMed PMID:29797095 PubMed Central PMC5996751.
  6. Chernikova, DA, Madan, JC, Housman, ML, Zain-Ul-Abideen, M, Lundgren, SN, Morrison, HG, Sogin, ML, Williams, SM, Moore, JH, Karagas, MR, Hoen, AG. The premature infant gut microbiome during the first 6 weeks of life differs based on gestational maturity at birth. Pediatr. Res. 2018; : . PubMed PMID:29795209 .
  7. Marrs, C, Chesmore, K, Menon, R, Williams, S. Maternal human telomerase reverse transcriptase variants are associated with preterm labor and preterm premature rupture of membranes. PLoS ONE 2018; 13 (5): e0195963. PubMed PMID:29771920 PubMed Central PMC5957404.
  8. Jazzar, U, Yong, S, Klaassen, Z, Huo, J, Hughes, BD, Esparza, E, Mehta, HB, Kim, SP, Tyler, DS, Freedland, SJ, Kamat, AM, Wolf, DV, Williams, SB. Impact of psychiatric illness on decreased survival in elderly patients with bladder cancer in the United States. Cancer 2018; : . PubMed PMID:29660813 .
  9. Hellwege, JN, Russell, SB, Williams, SM, Edwards, TL, Velez Edwards, DR. Gene-based evaluation of low-frequency variation and genetically-predicted gene expression impacting risk of keloid formation. Ann. Hum. Genet. 2018; 82 (4): 206-215. PubMed PMID:29484647 PubMed Central PMC5993571.
  10. Shiga, Y, Akiyama, M, Nishiguchi, KM, Sato, K, Shimozawa, N, Takahashi, A, Momozawa, Y, Hirata, M, Matsuda, K, Yamaji, T, Iwasaki, M, Tsugane, S, Oze, I, Mikami, H, Naito, M, Wakai, K, Yoshikawa, M, Miyake, M, Yamashiro, K, Japan Glaucoma Society Omics Group (JGS-OG), Kashiwagi, K, Iwata, T, Mabuchi, F, Takamoto, M, Ozaki, M, Kawase, K, Aihara, M, Araie, M, Yamamoto, T, Kiuchi, Y, Nakamura, M, Ikeda, Y, Sonoda, KH, Ishibashi, T, Nitta, K, Iwase, A, Shirato, S, Oka, Y, Satoh, M, Sasaki, M, Fuse, N, Suzuki, Y, Cheng, CY, Khor, CC, Baskaran, M, Perera, S, Aung, T, Vithana, EN, Cooke Bailey, JN, Kang, JH, Pasquale, LR, Haines, JL, NEIGHBORHOOD Consortium, Wiggs, JL, Burdon, KP, Gharahkhani, P, Hewitt, AW, Mackey, DA, MacGregor, S, Craig, JE, Allingham, RR, Hauser, M, Ashaye, A, Budenz, DL, Akafo, S, Williams, SEI, Kamatani, Y, Nakazawa, T, Kubo, M. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Hum. Mol. Genet. 2018; 27 (8): 1486-1496. PubMed PMID:29452408 .
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