xiaofeng_zhu_cropped

Xiaofeng Zhu, PhD

Professor

xxz10@case.edu | 216.368.0201 | Wolstein Research Bldg. Rm. 1317

Education

Ph.D. Biostatistics, Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 1998
M.S. Statistics, University of Cincinnati, Cincinnati, Ohio,1994
M.S. Mathematics, Peking University, Beijing, China, 1989
B.Sc. Mathematics, Peking University, Beijing, China, 1986

Research Interests

Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping.

Professional Memberships

The American Society of Human Genetics
The International Genetic Epidemiology Society
Fellow, the Royal Statistical Society

Software

Click here to download software

Recent Publications

  1. Franceschini, N, Giambartolomei, C, de Vries, PS, Finan, C, Bis, JC, Huntley, RP, Lovering, RC, Tajuddin, SM, Winkler, TW, Graff, M, Kavousi, M, Dale, C, Smith, AV, Hofer, E, van Leeuwen, EM, Nolte, IM, Lu, L, Scholz, M, Sargurupremraj, M, Pitkänen, N, Franzén, O, Joshi, PK, Noordam, R, Marioni, RE, Hwang, SJ, Musani, SK, Schminke, U, Palmas, W, Isaacs, A, Correa, A, Zonderman, AB, Hofman, A, Teumer, A, Cox, AJ, Uitterlinden, AG, Wong, A, Smit, AJ, Newman, AB, Britton, A, Ruusalepp, A, Sennblad, B, Hedblad, B, Pasaniuc, B, Penninx, BW, Langefeld, CD, Wassel, CL, Tzourio, C, Fava, C, Baldassarre, D, O'Leary, DH, Teupser, D, Kuh, D, Tremoli, E, Mannarino, E, Grossi, E, Boerwinkle, E, Schadt, EE, Ingelsson, E, Veglia, F, Rivadeneira, F, Beutner, F, Chauhan, G, Heiss, G, Snieder, H, Campbell, H, Völzke, H, Markus, HS, Deary, IJ, Jukema, JW, de Graaf, J, Price, J, Pott, J, Hopewell, JC, Liang, J, Thiery, J, Engmann, J, Gertow, K, Rice, K, Taylor, KD, Dhana, K, Kiemeney, LALM, Lind, L, Raffield, LM, Launer, LJ, Holdt, LM, Dörr, M, Dichgans, M, Traylor, M, Sitzer, M, Kumari, M, Kivimaki, M, Nalls, MA, Melander, O, Raitakari, O, Franco, OH, Rueda-Ochoa, OL, Roussos, P, Whincup, PH, Amouyel, P, Giral, P, Anugu, P, Wong, Q, Malik, R, Rauramaa, R, Burkhardt, R, Hardy, R, Schmidt, R, de Mutsert, R, Morris, RW, Strawbridge, RJ, Wannamethee, SG, Hägg, S, Shah, S, McLachlan, S, Trompet, S, Seshadri, S, Kurl, S, Heckbert, SR, Ring, S, Harris, TB, Lehtimäki, T, Galesloot, TE, Shah, T, de Faire, U, Plagnol, V, Rosamond, WD, Post, W, Zhu, X, Zhang, X, Guo, X, Saba, Y, MEGASTROKE Consortium, Dehghan, A, Seldenrijk, A, Morrison, AC, Hamsten, A, Psaty, BM, van Duijn, CM, Lawlor, DA, Mook-Kanamori, DO, Bowden, DW, Schmidt, H, Wilson, JF, Wilson, JG, Rotter, JI, Wardlaw, JM, Deanfield, J, Halcox, J, Lyytikäinen, LP, Loeffler, M, Evans, MK, Debette, S, Humphries, SE, Völker, U, Gudnason, V, Hingorani, AD, Björkegren, JLM, Casas, JP, O'Donnell, CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun 2018; 9 (1): 5141. PubMed PMID:30510157 PubMed Central PMC6277418.
  2. Wang, H, Cade, BE, Sofer, T, Sands, SA, Chen, H, Browning, S, Stilp, AM, Louie, TL, Thornton, TA, Craig Johnson, W, Below, JE, Conomos, MP, Evans, DS, Gharib, SA, Guo, X, Frazier-Wood, AC, Mei, H, Yaffe, K, Loredo, JS, Ramos, AR, Barrett-Connor, E, Ancoli-Israel, S, Zee, PC, Arens, R, Shah, NA, Taylor, KD, Tranah, GJ, Stone, KL, Hanis, CL, Wilson, JG, Gottlieb, DJ, Patel, SR, Rice, K, Post, WS, Rotter, JI, Sunyaev, SR, Cai, J, Lin, X, Purcell, SM, Laurie, CC, Saxena, R, Redline, S, Zhu, X. Admixture mapping identifies novel loci for obstructive sleep apnea in hispanic/latino americans. Hum. Mol. Genet. 2018; : . PubMed PMID:30403821 .
  3. Wang, H, Nandakumar, P, Tekola-Ayele, F, Tayo, BO, Ware, EB, Gu, CC, Lu, Y, Yao, J, Zhao, W, Smith, JA, Hellwege, JN, Guo, X, Edwards, TL, Loos, RJF, Arnett, DK, Fornage, M, Rotimi, C, Kardia, SLR, Cooper, RS, Rao, DC, Ehret, G, Chakravarti, A, Zhu, X. Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31. Eur. J. Hum. Genet. 2018; : . PubMed PMID:30262922 .
  4. Wang, T, Xue, X, Xie, X, Ye, K, Zhu, X, Elston, RC. Adjustment for covariates using summary statistics of genome-wide association studies. Genet. Epidemiol. 2018; 42 (8): 812-825. PubMed PMID:30238496 PubMed Central PMC6239891.
  5. Feitosa, MF, Kraja, AT, Chasman, DI, Sung, YJ, Winkler, TW, Ntalla, I, Guo, X, Franceschini, N, Cheng, CY, Sim, X, Vojinovic, D, Marten, J, Musani, SK, Li, C, Bentley, AR, Brown, MR, Schwander, K, Richard, MA, Noordam, R, Aschard, H, Bartz, TM, Bielak, LF, Dorajoo, R, Fisher, V, Hartwig, FP, Horimoto, ARVR, Lohman, KK, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Wojczynski, MK, Alver, M, Boissel, M, Cai, Q, Campbell, A, Chai, JF, Chen, X, Divers, J, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, He, M, Hsu, FC, Jackson, AU, Kähönen, M, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Luan, J, Matoba, N, Nolte, IM, Padmanabhan, S, Riaz, M, Rueedi, R, Robino, A, Said, MA, Scott, RA, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, BO, van der Most, PJ, Varga, TV, Vitart, V, Wang, Y, Ware, EB, Warren, HR, Weiss, S, Wen, W, Yanek, LR, Zhang, W, Zhao, JH, Afaq, S, Amin, N, Amini, M, Arking, DE, Aung, T, Boerwinkle, E, Borecki, I, Broeckel, U, Brown, M, Brumat, M, Burke, GL, Canouil, M, Chakravarti, A, Charumathi, S, Ida Chen, YD, Connell, JM, Correa, A, de Las Fuentes, L, de Mutsert, R, de Silva, HJ, Deng, X, Ding, J, Duan, Q, Eaton, CB, Ehret, G, Eppinga, RN, Evangelou, E, Faul, JD, Felix, SB, Forouhi, NG, Forrester, T, Franco, OH, Friedlander, Y, Gandin, I, Gao, H, Ghanbari, M, Gigante, B, Gu, CC, Gu, D, Hagenaars, SP, Hallmans, G, Harris, TB, He, J, Heikkinen, S, Heng, CK, Hirata, M, Howard, BV, Ikram, MA, InterAct Consortium, John, U, Katsuya, T, Khor, CC, Kilpeläinen, TO, Koh, WP, Krieger, JE, Kritchevsky, SB, Kubo, M, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lehne, B, Lewis, CE, Li, Y, Lin, S, Liu, J, Liu, J, Loh, M, Louie, T, Mägi, R, McKenzie, CA, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, KL, Momozawa, Y, Nalls, MA, Nelson, CP, Sotoodehnia, N, Norris, JM, O'Connell, JR, Palmer, ND, Perls, T, Pedersen, NL, Peters, A, Peyser, PA, Poulter, N, Raffel, LJ, Raitakari, OT, Roll, K, Rose, LM, Rosendaal, FR, Rotter, JI, Schmidt, CO, Schreiner, PJ, Schupf, N, Scott, WR, Sever, PS, Shi, Y, Sidney, S, Sims, M, Sitlani, CM, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Stringham, HM, Tan, NYQ, Tang, H, Taylor, KD, Teo, YY, Tham, YC, Turner, ST, Uitterlinden, AG, Vollenweider, P, Waldenberger, M, Wang, L, Wang, YX, Wei, WB, Williams, C, Yao, J, Yu, C, Yuan, JM, Zhao, W, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Deary, IJ, Esko, T, Farrall, M, Franks, PW, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Jonas, JB, Kamatani, Y, Kato, N, Kooner, JS, Kutalik, Z, Laakso, M, Laurie, CC, Leander, K, Lehtimäki, T, Study, LC, Magnusson, PKE, Oldehinkel, AJ, Penninx, BWJH, Polasek, O, Porteous, DJ, Rauramaa, R, Samani, NJ, Scott, J, Shu, XO, van der Harst, P, Wagenknecht, LE, Wareham, NJ, Watkins, H, Weir, DR, Wickremasinghe, AR, Wu, T, Zheng, W, Bouchard, C, Christensen, K, Evans, MK, Gudnason, V, Horta, BL, Kardia, SLR, Liu, Y, Pereira, AC, Psaty, BM, Ridker, PM, van Dam, RM, Gauderman, WJ, Zhu, X, Mook-Kanamori, DO, Fornage, M, Rotimi, CN, Cupples, LA, Kelly, TN, Fox, ER, Hayward, C, van Duijn, CM, Tai, ES, Wong, TY, Kooperberg, C, Palmas, W, Rice, K, Morrison, AC, Elliott, P, Caulfield, MJ, Munroe, PB, Rao, DC, Province, MA, Levy, D. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE 2018; 13 (6): e0198166. PubMed PMID:29912962 PubMed Central PMC6005576.
  6. Laville, V, Bentley, AR, Privé, F, Zhu, X, Gauderman, J, Winkler, TW, Province, M, Rao, DC, Aschard, H. VarExp: estimating variance explained by genome-wide GxE summary statistics. Bioinformatics 2018; 34 (19): 3412-3414. PubMed PMID:29726908 PubMed Central PMC6157079.
  7. Sung, YJ, Winkler, TW, de Las Fuentes, L, Bentley, AR, Brown, MR, Kraja, AT, Schwander, K, Ntalla, I, Guo, X, Franceschini, N, Lu, Y, Cheng, CY, Sim, X, Vojinovic, D, Marten, J, Musani, SK, Li, C, Feitosa, MF, Kilpeläinen, TO, Richard, MA, Noordam, R, Aslibekyan, S, Aschard, H, Bartz, TM, Dorajoo, R, Liu, Y, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Tayo, BO, Warren, HR, Zhao, W, Zhou, Y, Matoba, N, Sofer, T, Alver, M, Amini, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Gandin, I, Gao, C, Giulianini, F, Goel, A, Harris, SE, Hartwig, FP, Horimoto, ARVR, Hsu, FC, Jackson, AU, Kähönen, M, Kasturiratne, A, Kühnel, B, Leander, K, Lee, WJ, Lin, KH, 'an Luan, J, McKenzie, CA, Meian, H, Nelson, CP, Rauramaa, R, Schupf, N, Scott, RA, Sheu, WHH, Stančáková, A, Takeuchi, F, van der Most, PJ, Varga, TV, Wang, H, Wang, Y, Ware, EB, Weiss, S, Wen, W, Yanek, LR, Zhang, W, Zhao, JH, Afaq, S, Alfred, T, Amin, N, Arking, D, Aung, T, Barr, RG, Bielak, LF, Boerwinkle, E, Bottinger, EP, Braund, PS, Brody, JA, Broeckel, U, Cabrera, CP, Cade, B, Caizheng, Y, Campbell, A, Canouil, M, Chakravarti, A, CHARGE Neurology Working Group, Chauhan, G, Christensen, K, Cocca, M, COGENT-Kidney Consortium, Collins, FS, Connell, JM, de Mutsert, R, de Silva, HJ, Debette, S, Dörr, M, Duan, Q, Eaton, CB, Ehret, G, Evangelou, E, Faul, JD, Fisher, VA, Forouhi, NG, Franco, OH, Friedlander, Y, Gao, H, GIANT Consortium, Gigante, B, Graff, M, Gu, CC, Gu, D, Gupta, P, Hagenaars, SP, Harris, TB, He, J, Heikkinen, S, Heng, CK, Hirata, M, Hofman, A, Howard, BV, Hunt, S, Irvin, MR, Jia, Y, Joehanes, R, Justice, AE, Katsuya, T, Kaufman, J, Kerrison, ND, Khor, CC, Koh, WP, Koistinen, HA, Komulainen, P, Kooperberg, C, Krieger, JE, Kubo, M, Kuusisto, J, Langefeld, CD, Langenberg, C, Launer, LJ, Lehne, B, Lewis, CE, Li, Y, Lifelines Cohort Study, Lim, SH, Lin, S, Liu, CT, Liu, J, Liu, J, Liu, K, Liu, Y, Loh, M, Lohman, KK, Long, J, Louie, T, Mägi, R, Mahajan, A, Meitinger, T, Metspalu, A, Milani, L, Momozawa, Y, Morris, AP, Mosley, TH Jr, Munson, P, Murray, AD, Nalls, MA, Nasri, U, Norris, JM, North, K, Ogunniyi, A, Padmanabhan, S, Palmas, WR, Palmer, ND, Pankow, JS, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Raitakari, OT, Renström, F, Rice, TK, Ridker, PM, Robino, A, Robinson, JG, Rose, LM, Rudan, I, Sabanayagam, C, Salako, BL, Sandow, K, Schmidt, CO, Schreiner, PJ, Scott, WR, Seshadri, S, Sever, P, Sitlani, CM, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Tang, H, Taylor, KD, Teo, YY, Tham, YC, Uitterlinden, AG, Waldenberger, M, Wang, L, Wang, YX, Wei, WB, Williams, C, Wilson, G, Wojczynski, MK, Yao, J, Yuan, JM, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Chen, YI, de Faire, U, Deary, IJ, Esko, T, Farrall, M, Forrester, T, Franks, PW, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BL, Hung, YJ, Jonas, JB, Kato, N, Kooner, JS, Laakso, M, Lehtimäki, T, Liang, KW, Magnusson, PKE, Newman, AB, Oldehinkel, AJ, Pereira, AC, Redline, S, Rettig, R, Samani, NJ, Scott, J, Shu, XO, van der Harst, P, Wagenknecht, LE, Wareham, NJ, Watkins, H, Weir, DR, Wickremasinghe, AR, Wu, T, Zheng, W, Kamatani, Y, Laurie, CC, Bouchard, C, Cooper, RS, Evans, MK, Gudnason, V, Kardia, SLR, Kritchevsky, SB, Levy, D, O'Connell, JR, Psaty, BM, van Dam, RM, Sims, M, Arnett, DK, Mook-Kanamori, DO, Kelly, TN, Fox, ER, Hayward, C, Fornage, M, Rotimi, CN, Province, MA, van Duijn, CM, Tai, ES, Wong, TY, Loos, RJF, Reiner, AP, Rotter, JI, Zhu, X, Bierut, LJ, Gauderman, WJ, Caulfield, MJ, Elliott, P, Rice, K, Munroe, PB, Morrison, AC, Cupples, LA, Rao, DC, Chasman, DI. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am. J. Hum. Genet. 2018; 102 (3): 375-400. PubMed PMID:29455858 PubMed Central PMC5985266.
  8. Li, X, Redline, S, Zhang, X, Williams, S, Zhu, X. Height associated variants demonstrate assortative mating in human populations. Sci Rep 2017; 7 (1): 15689. PubMed PMID:29146993 PubMed Central PMC5691191.
  9. Chen, H, Cade, BE, Gleason, KJ, Bjonnes, AC, Stilp, AM, Sofer, T, Conomos, MP, Ancoli-Israel, S, Arens, R, Azarbarzin, A, Bell, GI, Below, JE, Chun, S, Evans, DS, Ewert, R, Frazier-Wood, AC, Gharib, SA, Haba-Rubio, J, Hagen, EW, Heinzer, R, Hillman, DR, Johnson, WC, Kutalik, Z, Lane, JM, Larkin, EK, Lee, SK, Liang, J, Loredo, JS, Mukherjee, S, Palmer, LJ, Papanicolaou, GJ, Penzel, T, Peppard, PE, Post, WS, Ramos, AR, Rice, K, Rotter, JI, Sands, SA, Shah, NA, Shin, C, Stone, KL, Stubbe, B, Sul, JH, Tafti, M, Taylor, KD, Teumer, A, Thornton, TA, Tranah, GJ, Wang, C, Wang, H, Warby, SC, Wellman, DA, Zee, PC, Hanis, CL, Laurie, CC, Gottlieb, DJ, Patel, SR, Zhu, X, Sunyaev, SR, Saxena, R, Lin, X, Redline, S. Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am. J. Respir. Cell Mol. Biol. 2018; 58 (3): 391-401. PubMed PMID:29077507 PubMed Central PMC5854957.
  10. Sun, X, Chandar, AK, Canto, MI, Thota, PN, Brock, M, Shaheen, NJ, Beer, DG, Wang, JS, Falk, GW, Iyer, PG, Abrams, JA, Venkat-Ramani, M, Veigl, M, Miron, A, Willis, J, Patil, DT, Nalbantoglu, I, Guda, K, Markowitz, SD, Zhu, X, Elston, R, Chak, A. Genomic regions associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study. PLoS ONE 2017; 12 (10): e0184962. PubMed PMID:29073141 PubMed Central PMC5657624.
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