xiaofeng_zhu_cropped

Xiaofeng Zhu, PhD

Professor

xxz10@case.edu | 216.368.0201 | Wolstein Research Bldg. Rm. 1317

Education

Ph.D. Biostatistics, Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 1998
M.S. Statistics, University of Cincinnati, Cincinnati, Ohio,1994
M.S. Mathematics, Peking University, Beijing, China, 1989
B.Sc. Mathematics, Peking University, Beijing, China, 1986

Research Interests

Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping.

Professional Memberships

The American Society of Human Genetics
The International Genetic Epidemiology Society
Fellow, the Royal Statistical Society

Software

Click here to download software

Recent Publications

  1. Bai, WY, Wang, L, Ying, ZM, Hu, B, Xu, L, Zhang, GQ, Cong, PK, Zhu, X, Zou, W, Zheng, HF. Identification of PIEZO1 polymorphisms for human bone mineral density. Bone 2020; 133 : 115247. PubMed PMID:31968281 .
  2. Yan, T, Liang, J, Gao, J, Wang, L, Fujioka, H, Alzheimer Disease Neuroimaging Initiative, Zhu, X, Wang, X. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nat Commun 2020; 11 (1): 411. PubMed PMID:31964863 PubMed Central PMC6972869.
  3. Wang, H, Sofer, T, Zhang, X, Elston, RC, Redline, S, Zhu, X. Local Ancestry Inference in Large Pedigrees. Sci Rep 2020; 10 (1): 189. PubMed PMID:31932708 PubMed Central PMC6957497.
  4. Noordam, R, Bos, MM, Wang, H, Winkler, TW, Bentley, AR, Kilpeläinen, TO, de Vries, PS, Sung, YJ, Schwander, K, Cade, BE, Manning, A, Aschard, H, Brown, MR, Chen, H, Franceschini, N, Musani, SK, Richard, M, Vojinovic, D, Aslibekyan, S, Bartz, TM, de Las Fuentes, L, Feitosa, M, Horimoto, AR, Ilkov, M, Kho, M, Kraja, A, Li, C, Lim, E, Liu, Y, Mook-Kanamori, DO, Rankinen, T, Tajuddin, SM, van der Spek, A, Wang, Z, Marten, J, Laville, V, Alver, M, Evangelou, E, Graff, ME, He, M, Kühnel, B, Lyytikäinen, LP, Marques-Vidal, P, Nolte, IM, Palmer, ND, Rauramaa, R, Shu, XO, Snieder, H, Weiss, S, Wen, W, Yanek, LR, Adolfo, C, Ballantyne, C, Bielak, L, Biermasz, NR, Boerwinkle, E, Dimou, N, Eiriksdottir, G, Gao, C, Gharib, SA, Gottlieb, DJ, Haba-Rubio, J, Harris, TB, Heikkinen, S, Heinzer, R, Hixson, JE, Homuth, G, Ikram, MA, Komulainen, P, Krieger, JE, Lee, J, Liu, J, Lohman, KK, Luik, AI, Mägi, R, Martin, LW, Meitinger, T, Metspalu, A, Milaneschi, Y, Nalls, MA, O'Connell, J, Peters, A, Peyser, P, Raitakari, OT, Reiner, AP, Rensen, PCN, Rice, TK, Rich, SS, Roenneberg, T, Rotter, JI, Schreiner, PJ, Shikany, J, Sidney, SS, Sims, M, Sitlani, CM, Sofer, T, Strauch, K, Swertz, MA, Taylor, KD, Uitterlinden, AG, van Duijn, CM, Völzke, H, Waldenberger, M, Wallance, RB, van Dijk, KW, Yu, C, Zonderman, AB, Becker, DM, Elliott, P, Esko, T, Gieger, C, Grabe, HJ, Lakka, TA, Lehtimäki, T, North, KE, Penninx, BWJH, Vollenweider, P, Wagenknecht, LE, Wu, T, Xiang, YB, Zheng, W, Arnett, DK, Bouchard, C, Evans, MK, Gudnason, V, Kardia, S, Kelly, TN, Kritchevsky, SB, Loos, RJF, Pereira, AC, Province, M, Psaty, BM, Rotimi, C, Zhu, X, Amin, N, Cupples, LA, Fornage, M, Fox, EF, Guo, X, Gauderman, WJ, Rice, K, Kooperberg, C, Munroe, PB, Liu, CT, Morrison, AC, Rao, DC, van Heemst, D, Redline, S. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun 2019; 10 (1): 5121. PubMed PMID:31719535 PubMed Central PMC6851116.
  5. Liang, J, Cade, BE, He, KY, Wang, H, Lee, J, Sofer, T, Williams, S, Li, R, Chen, H, Gottlieb, DJ, Evans, DS, Guo, X, Gharib, SA, Hale, L, Hillman, DR, Lutsey, PL, Mukherjee, S, Ochs-Balcom, HM, Palmer, LJ, Rhodes, J, Purcell, S, Patel, SR, Saxena, R, Stone, KL, Tang, W, Tranah, GJ, Boerwinkle, E, Lin, X, Liu, Y, Psaty, BM, Vasan, RS, Cho, MH, Manichaikul, A, Silverman, EK, Barr, RG, Rich, SS, Rotter, JI, Wilson, JG, NHLBI Trans-Omics for Precision Medicine (TOPMed), TOPMed Sleep Working Group, Redline, S, Zhu, X. Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level. Am. J. Hum. Genet. 2019; 105 (5): 1057-1068. PubMed PMID:31668705 PubMed Central PMC6849112.
  6. Wang, H, Lane, JM, Jones, SE, Dashti, HS, Ollila, HM, Wood, AR, van Hees, VT, Brumpton, B, Winsvold, BS, Kantojärvi, K, Palviainen, T, Cade, BE, Sofer, T, Song, Y, Patel, K, Anderson, SG, Bechtold, DA, Bowden, J, Emsley, R, Kyle, SD, Little, MA, Loudon, AS, Scheer, FAJL, Purcell, SM, Richmond, RC, Spiegelhalder, K, Tyrrell, J, Zhu, X, Hublin, C, Kaprio, JA, Kristiansson, K, Sulkava, S, Paunio, T, Hveem, K, Nielsen, JB, Willer, CJ, Zwart, JA, Strand, LB, Frayling, TM, Ray, D, Lawlor, DA, Rutter, MK, Weedon, MN, Redline, S, Saxena, R. Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nat Commun 2019; 10 (1): 3503. PubMed PMID:31409809 PubMed Central PMC6692391.
  7. Barfield, R, Wang, H, Liu, Y, Brody, JA, Swenson, B, Li, R, Bartz, TM, Sotoodehnia, N, Chen, YI, Cade, BE, Chen, H, Patel, SR, Zhu, X, Gharib, SA, Johnson, WC, Rotter, JI, Saxena, R, Purcell, S, Lin, X, Redline, S, Sofer, T. Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations. Sleep 2019; 42 (8): . PubMed PMID:31139831 PubMed Central PMC6685317.
  8. Sung, YJ, de Las Fuentes, L, Winkler, TW, Chasman, DI, Bentley, AR, Kraja, AT, Ntalla, I, Warren, HR, Guo, X, Schwander, K, Manning, AK, Brown, MR, Aschard, H, Feitosa, MF, Franceschini, N, Lu, Y, Cheng, CY, Sim, X, Vojinovic, D, Marten, J, Musani, SK, Kilpeläinen, TO, Richard, MA, Aslibekyan, S, Bartz, TM, Dorajoo, R, Li, C, Liu, Y, Rankinen, T, Smith, AV, Tajuddin, SM, Tayo, BO, Zhao, W, Zhou, Y, Matoba, N, Sofer, T, Alver, M, Amini, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Gandin, I, Gao, C, Giulianini, F, Goel, A, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, FC, Jackson, AU, Kammerer, CM, Kasturiratne, A, Komulainen, P, Kühnel, B, Leander, K, Lee, WJ, Lin, KH, Luan, J, Lyytikäinen, LP, McKenzie, CA, Nelson, CP, Noordam, R, Scott, RA, Sheu, WHH, Stančáková, A, Takeuchi, F, van der Most, PJ, Varga, TV, Waken, RJ, Wang, H, Wang, Y, Ware, EB, Weiss, S, Wen, W, Yanek, LR, Zhang, W, Zhao, JH, Afaq, S, Alfred, T, Amin, N, Arking, DE, Aung, T, Barr, RG, Bielak, LF, Boerwinkle, E, Bottinger, EP, Braund, PS, Brody, JA, Broeckel, U, Cade, B, Campbell, A, Canouil, M, Chakravarti, A, Cocca, M, Collins, FS, Connell, JM, de Mutsert, R, de Silva, HJ, Dörr, M, Duan, Q, Eaton, CB, Ehret, G, Evangelou, E, Faul, JD, Forouhi, NG, Franco, OH, Friedlander, Y, Gao, H, Gigante, B, Gu, CC, Gupta, P, Hagenaars, SP, Harris, TB, He, J, Heikkinen, S, Heng, CK, Hofman, A, Howard, BV, Hunt, SC, Irvin, MR, Jia, Y, Katsuya, T, Kaufman, J, Kerrison, ND, Khor, CC, Koh, WP, Koistinen, HA, Kooperberg, CB, Krieger, JE, Kubo, M, Kutalik, Z, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lee, JH, Lehne, B, Levy, D, Lewis, CE, Li, Y, Lifelines Cohort Study, Lim, SH, Liu, CT, Liu, J, Liu, J, Liu, Y, Loh, M, Lohman, KK, Louie, T, Mägi, R, Matsuda, K, Meitinger, T, Metspalu, A, Milani, L, Momozawa, Y, Mosley, TH Jr, Nalls, MA, Nasri, U, O'Connell, JR, Ogunniyi, A, Palmas, WR, Palmer, ND, Pankow, JS, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Porteous, D, Raitakari, OT, Renström, F, Rice, TK, Ridker, PM, Robino, A, Robinson, JG, Rose, LM, Rudan, I, Sabanayagam, C, Salako, BL, Sandow, K, Schmidt, CO, Schreiner, PJ, Scott, WR, Sever, P, Sims, M, Sitlani, CM, Smith, BH, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Tang, H, Taylor, KD, Teo, YY, Tham, YC, Uitterlinden, AG, Waldenberger, M, Wang, L, Wang, YX, Wei, WB, Wilson, G, Wojczynski, MK, Xiang, YB, Yao, J, Yuan, JM, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Chen, YI, Weir, DR, de Faire, U, Deary, IJ, Esko, T, Farrall, M, Forrester, T, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BL, Hung, YJ, Jonas, JB, Kato, N, Kooner, JS, Laakso, M, Lehtimäki, T, Liang, KW, Magnusson, PKE, Oldehinkel, AJ, Pereira, AC, Perls, T, Rauramaa, R, Redline, S, Rettig, R, Samani, NJ, Scott, J, Shu, XO, van der Harst, P, Wagenknecht, LE, Wareham, NJ, Watkins, H, Wickremasinghe, AR, Wu, T, Kamatani, Y, Laurie, CC, Bouchard, C, Cooper, RS, Evans, MK, Gudnason, V, Hixson, J, Kardia, SLR, Kritchevsky, SB, Psaty, BM, van Dam, RM, Arnett, DK, Mook-Kanamori, DO, Fornage, M, Fox, ER, Hayward, C, van Duijn, CM, Tai, ES, Wong, TY, Loos, RJF, Reiner, AP, Rotimi, CN, Bierut, LJ, Zhu, X, Cupples, LA, Province, MA, Rotter, JI, Franks, PW, Rice, K, Elliott, P, Caulfield, MJ, Gauderman, WJ, Munroe, PB, Rao, DC, Morrison, AC. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum. Mol. Genet. 2019; : . PubMed PMID:31127295 PubMed Central PMC6644157.
  9. Cade, BE, Chen, H, Stilp, AM, Louie, T, Ancoli-Israel, S, Arens, R, Barfield, R, Below, JE, Cai, J, Conomos, MP, Evans, DS, Frazier-Wood, AC, Gharib, SA, Gleason, KJ, Gottlieb, DJ, Hillman, DR, Johnson, WC, Lederer, DJ, Lee, J, Loredo, JS, Mei, H, Mukherjee, S, Patel, SR, Post, WS, Purcell, SM, Ramos, AR, Reid, KJ, Rice, K, Shah, NA, Sofer, T, Taylor, KD, Thornton, TA, Wang, H, Yaffe, K, Zee, PC, Hanis, CL, Palmer, LJ, Rotter, JI, Stone, KL, Tranah, GJ, Wilson, JG, Sunyaev, SR, Laurie, CC, Zhu, X, Saxena, R, Lin, X, Redline, S. Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep. PLoS Genet. 2019; 15 (4): e1007739. PubMed PMID:30990817 PubMed Central PMC6467367.
  10. Qin, H, Zhao, J, Zhu, X. Identifying Rare Variant Associations in Admixed Populations. Sci Rep 2019; 9 (1): 5458. PubMed PMID:30931973 PubMed Central PMC6443736.
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