xiaofeng_zhu_cropped

Xiaofeng Zhu, PhD

Professor

xxz10@case.edu | 216.368.0201 | Wolstein Research Bldg. Rm. 1317

Education

Ph.D. Biostatistics, Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 1998
M.S. Statistics, University of Cincinnati, Cincinnati, Ohio,1994
M.S. Mathematics, Peking University, Beijing, China, 1989
B.Sc. Mathematics, Peking University, Beijing, China, 1986

Research Interests

Genetic mapping studies of hypertension, obesity; development of statistical methods for association studies avoiding the effect of population stratification; admixture mapping.

Professional Memberships

The American Society of Human Genetics
The International Genetic Epidemiology Society
Fellow, the Royal Statistical Society

Recent Publications

  1. Ouyang, W, Zhu, X, Qin, H. Detecting Multiethnic Rare Variants. Methods Mol. Biol. 2017; 1666 : 527-538. PubMed PMID:28980263 .
  2. Zhu, X, Wang, H. The Analysis of Ethnic Mixtures. Methods Mol. Biol. 2017; 1666 : 505-525. PubMed PMID:28980262 .
  3. Li, X, Zhu, X. Cross-Phenotype Association Analysis Using Summary Statistics from GWAS. Methods Mol. Biol. 2017; 1666 : 455-467. PubMed PMID:28980259 .
  4. Qin, H, Zhu, X. Calibrating Population Stratification in Association Analysis. Methods Mol. Biol. 2017; 1666 : 441-453. PubMed PMID:28980258 .
  5. Liang, J, Le, TH, Edwards, DRV, Tayo, BO, Gaulton, KJ, Smith, JA, Lu, Y, Jensen, RA, Chen, G, Yanek, LR, Schwander, K, Tajuddin, SM, Sofer, T, Kim, W, Kayima, J, McKenzie, CA, Fox, E, Nalls, MA, Young, JH, Sun, YV, Lane, JM, Cechova, S, Zhou, J, Tang, H, Fornage, M, Musani, SK, Wang, H, Lee, J, Adeyemo, A, Dreisbach, AW, Forrester, T, Chu, PL, Cappola, A, Evans, MK, Morrison, AC, Martin, LW, Wiggins, KL, Hui, Q, Zhao, W, Jackson, RD, Ware, EB, Faul, JD, Reiner, AP, Bray, M, Denny, JC, Mosley, TH, Palmas, W, Guo, X, Papanicolaou, GJ, Penman, AD, Polak, JF, Rice, K, Taylor, KD, Boerwinkle, E, Bottinger, EP, Liu, K, Risch, N, Hunt, SC, Kooperberg, C, Zonderman, AB, Laurie, CC, Becker, DM, Cai, J, Loos, RJF, Psaty, BM, Weir, DR, Kardia, SLR, Arnett, DK, Won, S, Edwards, TL, Redline, S, Cooper, RS, Rao, DC, Rotter, JI, Rotimi, C, Levy, D, Chakravarti, A, Zhu, X, Franceschini, N. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. PLoS Genet. 2017; 13 (5): e1006728. PubMed PMID:28498854 PubMed Central PMC5446189.
  6. Ng, MCY, Graff, M, Lu, Y, Justice, AE, Mudgal, P, Liu, CT, Young, K, Yanek, LR, Feitosa, MF, Wojczynski, MK, Rand, K, Brody, JA, Cade, BE, Dimitrov, L, Duan, Q, Guo, X, Lange, LA, Nalls, MA, Okut, H, Tajuddin, SM, Tayo, BO, Vedantam, S, Bradfield, JP, Chen, G, Chen, WM, Chesi, A, Irvin, MR, Padhukasahasram, B, Smith, JA, Zheng, W, Allison, MA, Ambrosone, CB, Bandera, EV, Bartz, TM, Berndt, SI, Bernstein, L, Blot, WJ, Bottinger, EP, Carpten, J, Chanock, SJ, Chen, YI, Conti, DV, Cooper, RS, Fornage, M, Freedman, BI, Garcia, M, Goodman, PJ, Hsu, YH, Hu, J, Huff, CD, Ingles, SA, John, EM, Kittles, R, Klein, E, Li, J, McKnight, B, Nayak, U, Nemesure, B, Ogunniyi, A, Olshan, A, Press, MF, Rohde, R, Rybicki, BA, Salako, B, Sanderson, M, Shao, Y, Siscovick, DS, Stanford, JL, Stevens, VL, Stram, A, Strom, SS, Vaidya, D, Witte, JS, Yao, J, Zhu, X, Ziegler, RG, Zonderman, AB, Adeyemo, A, Ambs, S, Cushman, M, Faul, JD, Hakonarson, H, Levin, AM, Nathanson, KL, Ware, EB, Weir, DR, Zhao, W, Zhi, D, Bone Mineral Density in Childhood Study (BMDCS) Group, Arnett, DK, Grant, SFA, Kardia, SLR, Oloapde, OI, Rao, DC, Rotimi, CN, Sale, MM, Williams, LK, Zemel, BS, Becker, DM, Borecki, IB, Evans, MK, Harris, TB, Hirschhorn, JN, Li, Y, Patel, SR, Psaty, BM, Rotter, JI, Wilson, JG, Bowden, DW, Cupples, LA, Haiman, CA, Loos, RJF, North, KE. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet. 2017; 13 (4): e1006719. PubMed PMID:28430825 PubMed Central PMC5419579.
  7. He, KY, Wang, H, Cade, BE, Nandakumar, P, Giri, A, Ware, EB, Haessler, J, Liang, J, Smith, JA, Franceschini, N, Le, TH, Kooperberg, C, Edwards, TL, Kardia, SL, Lin, X, Chakravarti, A, Redline, S, Zhu, X. Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure. PLoS Genet. 2017; 13 (3): e1006678. PubMed PMID:28346479 PubMed Central PMC5386302.
  8. Lane, JM, Liang, J, Vlasac, I, Anderson, SG, Bechtold, DA, Bowden, J, Emsley, R, Gill, S, Little, MA, Luik, AI, Loudon, A, Scheer, FA, Purcell, SM, Kyle, SD, Lawlor, DA, Zhu, X, Redline, S, Ray, DW, Rutter, MK, Saxena, R. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat. Genet. 2017; 49 (2): 274-281. PubMed PMID:27992416 PubMed Central PMC5491693.
  9. Wang, H, Choi, Y, Tayo, B, Wang, X, Morris, N, Zhang, X, Broeckel, U, Hanis, C, Kardia, S, Redline, S, Cooper, RS, Tang, H, Zhu, X. Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Genet. Epidemiol. 2017; 41 (2): 122-135. PubMed PMID:27917522 PubMed Central PMC5226866.
  10. Wang, H, Cade, BE, Chen, H, Gleason, KJ, Saxena, R, Feng, T, Larkin, EK, Vasan, RS, Lin, H, Patel, SR, Tracy, RP, Liu, Y, Gottlieb, DJ, Below, JE, Hanis, CL, Petty, LE, Sunyaev, SR, Frazier-Wood, AC, Rotter, JI, Post, W, Lin, X, Redline, S, Zhu, X. Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level. Hum. Mol. Genet. 2016; 25 (23): 5244-5253. PubMed PMID:27798093 .
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